Giants vs Brewers Prediction, Odds, Moneyline, Spread & Over/Under for April 21

Odds updated as of 9:11 p.m.

The San Francisco Giants versus the Milwaukee Brewers is on the MLB schedule for Monday.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Giants vs Brewers Game Info

• San Francisco Giants (14-8) vs. Milwaukee Brewers (12-10)
• Date: Monday, April 21, 2025
• Time: 9:45 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: MLB Network, NBCS-BA, and FDSWI

Giants vs Brewers Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-136) | MIL: (+116)
• Spread: SF: -1.5 (+152) | MIL: +1.5 (-184)
• Total: 7.5 -- Over: (-120) | Under: (-102)

Giants vs Brewers Probable Starting Pitchers

Probable Pitchers: Robbie Ray (Giants) - 3-0, 4.19 ERA vs Quinn Priester (Brewers) - 1-0, 0.90 ERA

The probable starters are Robbie Ray (3-0) for the Giants and Quinn Priester (1-0) for the Brewers. Ray's team has covered the spread in each of the four opportunities this season. Ray's team is 2-0 this season when he starts and they're favored on the moneyline. Priester has started two games with set spreads, and the Brewers went 1-1-0. The Brewers were the underdog on the moneyline for one Priester start this season -- they won.

Giants vs Brewers Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (55.4%)

Giants vs Brewers Moneyline

• Milwaukee is the underdog, +116 on the moneyline, while San Francisco is a -136 favorite at home.

Giants vs Brewers Spread

• The Brewers are +1.5 on the spread (-184 to cover), and San Francisco is +152 to cover the runline.

Giants vs Brewers Over/Under

• The over/under for the Giants versus Brewers game on April 21 has been set at 7.5, with -120 odds on the over and -102 odds on the under.

Bet on San Francisco Giants vs. Milwaukee Brewers on FanDuel today!

Giants vs Brewers Betting Trends

• The Giants have come away with eight wins in the 11 contests they have been listed as the favorites in this season.
• This year San Francisco has won three of five games when listed as at least -136 on the moneyline.
• The Giants and their opponents have gone over in 14 of their 22 games with a total set by sportsbooks this season.
• The Giants have an against the spread mark of 12-10-0 in 22 games with a line this season.
• The Brewers have won 25% of the games this season they were the moneyline underdog (2-6).
• Milwaukee has gone 1-5 when playing as a moneyline underdog with odds of +116 or longer (16.7%).
• In the 22 games oddsmakers have set an over/under for the Brewers, they have combined with opponents to go over the total nine times (9-13-0).
• The Brewers have a 12-10-0 record against the spread this season.

Giants Player Leaders

• Jung Hoo Lee leads San Francisco with 27 hits and a team-best slugging percentage of .593. He's batting .333 with an on-base percentage of .389.
• He ranks 11th in batting average, 27th in on-base percentage, and 12th in slugging among qualified hitters in MLB.
• Matt James Chapman leads San Francisco in OBP (.406) this season, fueled by 18 hits. He's batting .240 while slugging .440.
• Among qualifying batters, he is 89th in batting average, 14th in on-base percentage and 61st in slugging percentage.
• Wilmer Flores has collected 16 base hits, an OBP of .250 and a slugging percentage of .430 this season.
• Mike Yastrzemski has been key for San Francisco with 17 hits, an OBP of .405 plus a slugging percentage of .525.

Brewers Player Leaders

• Brice Turang has racked up a slugging percentage of .437, a team-high for the Brewers. He's batting .322 with an on-base percentage of .358.
• Including all qualifying hitters, he is 16th in batting average, while his on-base percentage is 49th and he is 64th in slugging.
• Turang hopes to build on a three-game hitting streak in this matchup. In his last five games he is hitting .278 with two walks and an RBI.
• Jackson Chourio's 25 hits lead his team. He has a batting average of .260 while slugging .521 with an on-base percentage of .273.
• Including all qualifying hitters, he is 73rd in batting average, 135th in on-base percentage and 28th in slugging percentage.
• Sal Frelick has put up an on-base percentage of .432, a team-best for the Brewers.
• William Jesus (Castillo) Contreras has two doubles, three home runs and 13 walks while batting .230.

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