Cubs vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for May 25

Odds updated as of 1:11 a.m.

The Chicago Cubs are among the MLB squads playing on Sunday, up against the Cincinnati Reds.

We've got you covered, in terms of the most important info regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Cubs vs Reds Game Info

• Chicago Cubs (31-21) vs. Cincinnati Reds (26-27)
• Date: Sunday, May 25, 2025
• Time: 1:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: MLB Network, FDSOH, and MARQ

Cubs vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-112) | CIN: (-104)
• Spread: CHC: -1.5 (+134) | CIN: +1.5 (-162)
• Total: 9 -- Over: (-105) | Under: (-115)

Cubs vs Reds Probable Starting Pitchers

Probable Pitchers: Ben Brown (Cubs) - 3-3, 5.44 ERA vs Nick Lodolo (Reds) - 4-4, 3.22 ERA

The Cubs will give the nod to Ben Brown (3-3, 5.44 ERA), who is eyeing win No. 4 on the season, and the Reds will counter with Nick Lodolo (4-4, 3.22 ERA). Brown and his team have a record of 4-5-0 against the spread when he starts. Brown's team is 4-3 this season when he starts and they are the moneyline favorite. When Lodolo starts, the Reds are 6-4-0 against the spread. The Reds have been the moneyline underdog in four of Lodolo's starts this season, and they went 2-2 in those matchups.

Cubs vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (51.9%)

Cubs vs Reds Moneyline

• Cincinnati is the underdog, -104 on the moneyline, while Chicago is a -112 favorite despite being on the road.

Cubs vs Reds Spread

• The Reds are hosting the Cubs, and are +1.5 on the runline. The Reds are +134 to cover the spread, and the Cubs are -162.

Cubs vs Reds Over/Under

• An over/under of 9 has been set for Cubs-Reds on May 25, with the over being -105 and the under -115.

Bet on Chicago Cubs vs. Cincinnati Reds on FanDuel today!

Cubs vs Reds Betting Trends

• The Cubs have been favorites in 30 games this season and have come away with the win 21 times (70%) in those contests.
• This year Chicago has won 21 of 30 games when listed as at least -112 on the moneyline.
• The Cubs and their opponents have gone over in 32 of their 50 games with a total set by sportsbooks this season.
• The Cubs are 26-24-0 against the spread in their 50 games with a line set by sportsbooks this season.
• The Reds have been the underdog on the moneyline 28 total times this season. They've finished 13-15 in those games.
• In games it has played as a moneyline underdog with odds of -104 or longer, Cincinnati has an 11-13 record (winning 45.8% of its games).
• The Reds have played in 51 games with an over/under set, and have combined with opponents to go over the total 20 times (20-29-2).
• The Reds have covered 52.9% of their games this season, going 27-24-0 ATS.

Cubs Player Leaders

• Kyle Tucker has 57 hits this season and a team-best OBP of .383. He has a .279 batting average and a slugging percentage of .539.
• Among qualifying hitters in baseball, he is 43rd in batting average, 17th in on-base percentage, and 15th in slugging.
• Tucker has recorded at least one hit in four games in a row. During his last five outings he is batting .409 with two home runs, two walks and four RBIs.
• Pete Crow-Armstrong has 58 hits to go with a slugging percentage of .580, both of which are tops among Chicago hitters this season. He's batting .283 with an on-base percentage of .313.
• Among qualifying hitters, he is 35th in batting average, 106th in on-base percentage and fifth in slugging percentage.
• Seiya Suzuki has 51 hits this season and has a slash line of .263/.319/.552.
• Suzuki heads into this matchup with five games in a row with at least one hit. During his last five outings he is batting .429 with three doubles, two home runs, three walks and seven RBIs.
• Nico Hoerner is batting .295 with a .337 OBP and 22 RBI for Chicago this season.
• Hoerner enters this game on a two-game hitting streak. During his last five outings he is batting .333 with two doubles, a walk and two RBIs.

Reds Player Leaders

• Elly De La Cruz is leading the Reds with 51 hits. He's batting .248 and slugging .417 with an on-base percentage of .322.
• Including all qualified hitters in the big leagues, his batting average puts him 96th, his on-base percentage ranks 91st, and he is 83rd in slugging.
• TJ Friedl leads his team with a .397 slugging percentage. He has a batting average of .280 with an on-base percentage of .361.
• Including all qualifying hitters, he is 41st in batting average, 42nd in on-base percentage and 103rd in slugging percentage.
• Gavin Lux has a team-high .383 on-base percentage.
• Austin Hays is batting .317 with six doubles, a triple, six home runs and seven walks.

Cubs vs Reds Head to Head

• 5/24/2025: 6-4 CIN (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/23/2025: 13-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/29/2024: 3-0 CIN (Favorite: Reds, Spread: -1.5, Total: 7, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/28/2024: 3-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/27/2024: 1-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/31/2024: 13-4 CHC (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 7/30/2024: 6-3 CIN (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/29/2024: 7-1 CIN (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/9/2024: 4-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 6/8/2024: 4-3 CIN (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -122, Underdog Moneyline: +104)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!