Cubs vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for May 25

Odds updated as of 1:14 p.m.

The Sunday slate in MLB includes a matchup between the Chicago Cubs and the Cincinnati Reds.

All the info you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cubs vs Reds Game Info

• Chicago Cubs (31-21) vs. Cincinnati Reds (26-27)
• Date: Sunday, May 25, 2025
• Time: 1:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: MLB Network, FDSOH, and MARQ

Cubs vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-132) | CIN: (+112)
• Spread: CHC: -1.5 (+115) | CIN: +1.5 (-138)
• Total: 9 -- Over: (-102) | Under: (-120)

Cubs vs Reds Probable Starting Pitchers

Probable Pitchers: Ben Brown (Cubs) - 3-3, 5.44 ERA vs Nick Lodolo (Reds) - 4-4, 3.22 ERA

The Cubs will give the nod to Ben Brown (3-3) against the Reds and Nick Lodolo (4-4). Brown and his team have a record of 4-5-0 against the spread when he starts. When Brown starts a game and his team is the favorite on the moneyline, they have a record of 4-3. The Reds have gone 6-4-0 ATS in Lodolo's 10 starts that had a set spread. The Reds have a 2-2 record in Lodolo's four starts this season when they were the underdog on the moneyline.

Cubs vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (51%)

Cubs vs Reds Moneyline

• Looking at the moneyline for Cubs-Reds, Chicago is the favorite at -132, and Cincinnati is +112 playing at home.

Cubs vs Reds Spread

• The Reds are at +1.5 on the runline against the Cubs. The Reds are -138 to cover the spread, and the Cubs are +115.

Cubs vs Reds Over/Under

• The Cubs-Reds game on May 25 has been given an over/under of 9 runs. The over is set at -102 and the under at -120.

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Cubs vs Reds Betting Trends

• The Cubs have come away with 21 wins in the 30 contests they have been listed as the favorites in this season.
• This season Chicago has been victorious 15 times in 22 chances when named as a favorite of at least -132 on the moneyline.
• Contests with the Cubs have gone over the total set by bookmakers in 32 of 50 chances this season.
• The Cubs have an against the spread record of 26-24-0 in 50 games with a line this season.
• The Reds have won 13 of the 28 games they were listed as the moneyline underdog this season (46.4%).
• Cincinnati has a 3-8 record (winning just 27.3% of its games) when it has played as a moneyline underdog of +112 or longer.
• In the 51 games oddsmakers have set an over/under for the Reds, they have combined with opponents to go over the total 20 times (20-29-2).
• The Reds have covered 52.9% of their games this season, going 27-24-0 against the spread.

Cubs Player Leaders

• Kyle Tucker leads Chicago in OBP (.383) this season, fueled by 57 hits. He has a .279 batting average and a slugging percentage of .539.
• Among qualifying batters in the majors, he is 43rd in batting average, 17th in on-base percentage, and 15th in slugging.
• Tucker has recorded at least one hit in four straight games. During his last five outings he is hitting .409 with two home runs, two walks and four RBIs.
• Pete Crow-Armstrong leads Chicago in slugging percentage (.580) and total hits (58) this season. He's batting .283 with an on-base percentage of .313.
• Among qualified hitters, his batting average places him 35th, his on-base percentage 107th, and his slugging percentage fifth.
• Seiya Suzuki has 51 hits this season and has a slash line of .263/.319/.552.
• Suzuki takes a five-game hitting streak into this matchup. During his last five outings he is batting .429 with three doubles, two home runs, three walks and seven RBIs.
• Nico Hoerner has been key for Chicago with 56 hits, an OBP of .337 plus a slugging percentage of .374.
• Hoerner enters this game on a two-game hitting streak. During his last five outings he is batting .333 with two doubles, a walk and two RBIs.

Reds Player Leaders

• Elly De La Cruz has racked up 51 hits, a team-best for the Reds. He's batting .248 and slugging .417 with an on-base percentage of .322.
• Including all qualified hitters in the majors, his batting average places him 96th, his on-base percentage is 92nd, and he is 84th in slugging.
• TJ Friedl paces his team with a .397 slugging percentage. He has a batting average of .280 with an on-base percentage of .361.
• He is 41st in batting average, 42nd in on-base percentage and 104th in slugging percentage in MLB.
• Gavin Lux a has .383 on-base percentage to lead the Reds.
• Austin Hays has six doubles, a triple, six home runs and seven walks while batting .317.

Cubs vs Reds Head to Head

• 5/24/2025: 6-4 CIN (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/23/2025: 13-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/29/2024: 3-0 CIN (Favorite: Reds, Spread: -1.5, Total: 7, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/28/2024: 3-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/27/2024: 1-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/31/2024: 13-4 CHC (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 7/30/2024: 6-3 CIN (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/29/2024: 7-1 CIN (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/9/2024: 4-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 6/8/2024: 4-3 CIN (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -122, Underdog Moneyline: +104)

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