Cubs vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for June 6

Odds updated as of 2:12 p.m.

Saturday's slate in the MLB includes a matchup between the Chicago Cubs and the San Francisco Giants.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Cubs vs Giants Game Info

• Chicago Cubs (33-31) vs. San Francisco Giants (26-38)
• Date: Saturday, June 6, 2026
• Time: 2:20 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MARQ and NBCS-BA

Cubs vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-148) | SF: (+126)
• Spread: CHC: -1.5 (+142) | SF: +1.5 (-172)
• Total: 7.5 -- Over: (-108) | Under: (-112)

Cubs vs Giants Probable Starting Pitchers

Probable Pitchers: Ben Brown (Cubs) - 2-2, 1.92 ERA vs Landen Roupp (Giants) - 5-6, 4.22 ERA

The Cubs will give the nod to Ben Brown (2-2) against the Giants and Landen Roupp (5-6). When Brown starts, his team is 3-2-0 against the spread this season. Brown's team is 2-1 this season when he starts and they are the moneyline favorite. The Giants are 4-8-0 ATS in Roupp's 12 starts with a set spread. The Giants have a 4-4 record in Roupp's eight starts this season when they were the underdog on the moneyline.

Cubs vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (59%)

Cubs vs Giants Moneyline

• San Francisco is the underdog, +126 on the moneyline, while Chicago is a -148 favorite at home.

Cubs vs Giants Spread

• The Cubs are hosting the Giants and are favored by 1.5 runs on the spread. The Cubs are +142 to cover the runline, with the Giants being -172.

Cubs vs Giants Over/Under

• The over/under for the Cubs versus Giants contest on June 6 has been set at 7.5, with -108 odds on the over and -112 odds on the under.

Bet on Chicago Cubs vs. San Francisco Giants on FanDuel today!

Cubs vs Giants Betting Trends

• The Cubs have been victorious in 22, or 53.7%, of the 41 contests they have been chosen as favorites in this season.
• This season Chicago has come away with a win 11 times in 17 chances when named as a favorite of at least -148 on the moneyline.
• Contests with the Cubs have gone over the total set by oddsmakers in 35 of 62 chances this season.
• The Cubs have posted a record of 24-38-0 against the spread this season.
• The Giants have compiled a 15-27 record in games they were listed as the moneyline underdog (winning 35.7% of those games).
• San Francisco has a 7-6 record (winning 53.8% of its games) when playing as a moneyline underdog of +126 or longer.
• In the 63 games bookmakers have set an over/under for the Giants, they have combined with opponents to go over the total 32 times (32-27-4).
• The Giants have a 26-37-0 record against the spread this season.

Cubs Player Leaders

• Nico Hoerner has 14 doubles, four home runs and 29 walks while hitting .250. He has an on-base percentage of .333 and a slugging percentage of .353.
• Among qualifying hitters in MLB, his batting average ranks 82nd, his on-base percentage ranks 79th, and he is 126th in slugging.
• Ian Happ leads Chicago in total hits (53) this season while batting .235 with 28 extra-base hits. He's slugging .487 with an on-base percentage of .350.
• Among all qualified hitters, he ranks 111th in batting average, 55th in on-base percentage and 33rd in slugging percentage.
• Michael Busch leads Chicago with an OBP of .368 this season while batting .242 with 42 walks and 27 runs scored.
• Pete Crow-Armstrong has nine home runs, 30 RBI and a batting average of .248 this season.
• Crow-Armstrong has safely hit in 10 games in a row. During his last 10 outings he is hitting .366 with three doubles, three home runs, three walks and seven RBIs.

Giants Player Leaders

• Luis Arraez has a team-high OBP (.364) and slugging percentage (.439). He's batting .326.
• Including all qualifying hitters in the big leagues, he ranks third in batting average, 35th in on-base percentage and 64th in slugging percentage.
• Arraez brings a six-game hitting streak into this game. During his last 10 outings he is hitting .368 with three doubles, a triple, two walks and seven RBIs.
• Casey Schmitt's 65 hits lead his team. He has a batting average of .293 while slugging .559 with an on-base percentage of .325.
• Including all qualifying hitters, his batting average puts him 20th, his on-base percentage is 96th, and he is fifth in slugging.
• Jung Hoo Lee has 14 doubles, two triples, three home runs and 10 walks while batting .321.
• Willy Adames is hitting .250 with 18 doubles, a triple, 11 home runs and 16 walks.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!