Cardinals vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for May 10

Odds updated as of 3:11 p.m.

The St. Louis Cardinals will face the Washington Nationals in MLB action on Saturday.

All the information you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cardinals vs Nationals Game Info

• St. Louis Cardinals (20-19) vs. Washington Nationals (17-22)
• Date: Saturday, May 10, 2025
• Time: 4:05 p.m. ET
• Venue: Nationals Park -- Washington, District of Columbia
• Coverage: MASN and FDSMW

Cardinals vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-116) | WSH: (-102)
• Spread: STL: -1.5 (+146) | WSH: +1.5 (-176)
• Total: 9 -- Over: (-118) | Under: (-104)

Cardinals vs Nationals Probable Starting Pitchers

Probable Pitchers: Andre Pallante (Cardinals) - 2-2, 4.75 ERA vs Trevor Williams (Nationals) - 2-3, 5.86 ERA

The Cardinals will give the ball to Andre Pallante (2-2, 4.75 ERA), who is eyeing win No. 3 on the season, and the Nationals will turn to Trevor Williams (2-3, 5.86 ERA). Pallante's team is 4-3-0 against the spread this season in his starts. Pallante has yet to start a game this season when his team was the moneyline favorite. The Nationals are 5-2-0 against the spread when Williams starts. The Nationals have been the underdog on the moneyline in seven of Williams' starts this season, and they went 3-4 in those matchups.

Cardinals vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (51.3%)

Cardinals vs Nationals Moneyline

• The Cardinals vs Nationals moneyline has St. Louis as a -116 favorite, while Washington is a -102 underdog at home.

Cardinals vs Nationals Spread

• The Nationals are at +1.5 on the runline against the Cardinals. The Nationals are -176 to cover the spread, and the Cardinals are +146.

Cardinals vs Nationals Over/Under

• Cardinals versus Nationals on May 10 has an over/under of 9 runs, with the odds on the over -118 and the under set at -104.

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Cardinals vs Nationals Betting Trends

• The Cardinals have come away with six wins in the 12 contests they have been listed as the favorites in this season.
• This season St. Louis has come away with a win five times in nine chances when named as a favorite of at least -116 on the moneyline.
• The Cardinals and their opponents have gone over in 22 of their 39 games with a total set by sportsbooks this season.
• The Cardinals have an against the spread mark of 20-19-0 in 39 games with a line this season.
• The Nationals have gone 14-14 in games they were the underdog on the moneyline (winning 50% of those games).
• When playing as a moneyline underdog with odds of -102 or longer, Washington has gone 13-13 (50%).
• In the 37 games bookmakers have set an over/under for the Nationals, they have combined with opponents to go over the total 21 times (21-16-0).
• The Nationals have covered 54.1% of their games this season, going 20-17-0 against the spread.

Cardinals Player Leaders

• Lars Nootbaar is batting .245 with eight doubles, five home runs and 29 walks. He has an on-base percentage of .373 while slugging .401.
• Among qualified hitters, he ranks 93rd in batting average, his on-base percentage ranks 35th, and he is 92nd in slugging.
• Nootbaar will look for his third straight game with a hit in this contest. In his last five games he is hitting .250 with two doubles, four walks and an RBI.
• Brendan Donovan leads St. Louis with 47 hits and an OBP of .386, plus a team-best slugging percentage of .469. He's batting .329.
• His batting average is sixth among qualified players, his on-base percentage 18th, and his slugging percentage 41st.
• Donovan takes a nine-game streak with at least one hit into this contest. In his last 10 games he is hitting .270 with two doubles, five walks and three RBIs.
• Nolan Arenado has 36 hits this season and has a slash line of .269/.351/.403.
• Arenado has logged a hit or more in five straight games. During his last five outings he is hitting .450 with two walks and an RBI.
• Victor Scott II has been key for St. Louis with 34 hits, an OBP of .361 plus a slugging percentage of .410.
• Scott heads into this game on a nine-game hitting streak. During his last 10 games he is hitting .367 with a double, a home run, six walks and six RBIs.

Nationals Player Leaders

• James Wood has totaled 42 hits with a .379 on-base percentage and a .547 slugging percentage, all club-bests for the Nationals. He's batting .280.
• Including all the qualified players in the big leagues, he is 39th in batting average, 25th in on-base percentage and 13th in slugging percentage.
• Wood brings an eight-game hitting streak into this game. During his last 10 games he is hitting .341 with four doubles, a home run, six walks and three RBIs.
• C.J. Abrams has six doubles, two triples, four home runs and eight walks while hitting .304. He's slugging .520 with an on-base percentage of .368.
• Nathaniel Lowe is hitting .248 with seven doubles, six home runs and 17 walks.
• Luis Garcia is batting .230 with five doubles, three home runs and 10 walks.

Cardinals vs Nationals Head to Head

• 5/9/2025: 10-0 STL (Favorite: Nationals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 7/28/2024: 4-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 7/27/2024: 14-3 WSH (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 7/26/2024: 10-8 WSH (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 7/8/2024: 6-0 STL (Favorite: Nationals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/7/2024: 8-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/6/2024: 14-6 WSH (Favorite: Nationals, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/5/2024: 7-6 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 7/16/2023: 8-4 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 7/15/2023: 9-6 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -196, Underdog Moneyline: +164)

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