Cardinals vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for May 10

Odds updated as of 4:15 a.m.

The Saturday slate in MLB includes a matchup between the St. Louis Cardinals and the Washington Nationals.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Cardinals vs Nationals Game Info

• St. Louis Cardinals (20-19) vs. Washington Nationals (17-22)
• Date: Saturday, May 10, 2025
• Time: 4:05 p.m. ET
• Venue: Nationals Park -- Washington, District of Columbia
• Coverage: MASN and FDSMW

Cardinals vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-118) | WSH: (-100)
• Spread: STL: -1.5 (+138) | WSH: +1.5 (-166)
• Total: 9 -- Over: (-108) | Under: (-112)

Cardinals vs Nationals Probable Starting Pitchers

Probable Pitchers: Andre Pallante (Cardinals) - 2-2, 4.75 ERA vs Trevor Williams (Nationals) - 2-3, 5.86 ERA

The probable starters are Andre Pallante (2-2) for the Cardinals and Trevor Williams (2-3) for the Nationals. Pallante's team is 4-3-0 against the spread this season in his starts. This will be Pallante's first game as the moneyline favorite this season. The Nationals are 5-2-0 ATS in Williams' seven starts that had a set spread. The Nationals are 3-4 in Williams' seven starts this season that they were the underdog on the moneyline.

Cardinals vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (50.9%)

Cardinals vs Nationals Moneyline

• St. Louis is the favorite, -118 on the moneyline, while Washington is a -100 underdog despite being at home.

Cardinals vs Nationals Spread

• The Cardinals are 1.5-run road favorites on the runline against the Nationals. The Cardinals are +138 to cover, and the Nationals are -166.

Cardinals vs Nationals Over/Under

• The over/under for Cardinals-Nationals on May 10 is 9. The over is -108, and the under is -112.

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Cardinals vs Nationals Betting Trends

• The Cardinals have come away with six wins in the 12 contests they have been listed as the favorites in this season.
• St. Louis has a record of 5-3 when favored by -118 or more this year.
• Contests with the Cardinals have gone over the total set by bookmakers in 22 of 39 chances this season.
• The Cardinals are 20-19-0 against the spread in their 39 games that had a posted line this season.
• The Nationals have won 50% of the games this season they were the moneyline underdog (14-14).
• Washington is 12-12 (winning 50% of its games) when it has played as a moneyline underdog of -100 or longer.
• The Nationals have played in 37 games with a set over/under, and have combined with their opponents to go over the total 21 times (21-16-0).
• The Nationals have collected a 20-17-0 record ATS this season (covering 54.1% of the time).

Cardinals Player Leaders

• Lars Nootbaar has eight doubles, five home runs and 29 walks while batting .245. He has an on-base percentage of .373 and a slugging percentage of .401.
• Among all qualified hitters in MLB, his batting average ranks 93rd, his on-base percentage ranks 35th, and he is 92nd in slugging.
• Nootbaar hopes to build on a two-game hitting streak in this matchup. During his last five outings he is batting .250 with two doubles, four walks and an RBI.
• Brendan Donovan leads St. Louis with 47 hits and an OBP of .386, plus a team-best slugging percentage of .469. He's batting .329.
• He ranks sixth in batting average, 18th in on-base percentage and 41st in slugging among qualifying hitters.
• Donovan takes a nine-game streak with at least one hit into this one. In his last 10 outings he is hitting .270 with two doubles, five walks and three RBIs.
• Nolan Arenado is batting .269 with a .403 slugging percentage and 14 RBI this year.
• Arenado takes a five-game hitting streak into this matchup. In his last five games he is hitting .450 with two walks and an RBI.
• Victor Scott II has two home runs, 16 RBI and a batting average of .291 this season.
• Scott enters this matchup on a nine-game hitting streak. In his last 10 games he is batting .367 with a double, a home run, six walks and six RBIs.

Nationals Player Leaders

• James Wood has put up a team-best OBP (.379) and slugging percentage (.547), while pacing the Nationals in hits (42, while batting .280).
• Including all qualifying hitters in the majors, his batting average puts him 39th, his on-base percentage is 25th, and he is 13th in slugging.
• Wood hopes to build on an eight-game hitting streak in this matchup. In his last 10 games he is batting .341 with four doubles, a home run, six walks and three RBIs.
• C.J. Abrams is batting .304 with six doubles, two triples, four home runs and eight walks. He's slugging .520 with an on-base percentage of .368.
• Nathaniel Lowe is batting .248 with seven doubles, six home runs and 17 walks.
• Luis Garcia is batting .230 with five doubles, three home runs and 10 walks.

Cardinals vs Nationals Head to Head

• 5/9/2025: 10-0 STL (Favorite: Nationals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 7/28/2024: 4-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 7/27/2024: 14-3 WSH (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 7/26/2024: 10-8 WSH (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 7/8/2024: 6-0 STL (Favorite: Nationals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/7/2024: 8-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/6/2024: 14-6 WSH (Favorite: Nationals, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/5/2024: 7-6 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 7/16/2023: 8-4 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 7/15/2023: 9-6 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -196, Underdog Moneyline: +164)

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