Giants vs Twins Prediction, Odds, Moneyline, Spread & Over/Under for May 10

Odds updated as of 7:11 p.m.

In MLB action on Saturday, the San Francisco Giants play the Minnesota Twins.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Giants vs Twins Game Info

• San Francisco Giants (24-15) vs. Minnesota Twins (19-20)
• Date: Saturday, May 10, 2025
• Time: 7:15 p.m. ET
• Venue: Target Field -- Minneapolis, Minnesota
• Coverage: FOX

Giants vs Twins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-116) | MIN: (-102)
• Spread: SF: -1.5 (+138) | MIN: +1.5 (-166)
• Total: 8.5 -- Over: (-124) | Under: (+102)

Giants vs Twins Probable Starting Pitchers

Probable Pitchers: Logan Webb (Giants) - 4-2, 2.61 ERA vs Joe Ryan (Twins) - 2-2, 2.93 ERA

The Giants will look to Logan Webb (4-2) against the Twins and Joe Ryan (2-2). Webb's team is 5-3-0 against the spread in his starts this season. Webb's team has won 57.1% of his starts when they are favored on the moneyline (4-3). The Twins have a 2-5-0 ATS record in Ryan's seven starts with a set spread. The Twins were named the moneyline underdog for two Ryan starts this season -- they lost both.

Giants vs Twins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (53.6%)

Giants vs Twins Moneyline

• Minnesota is the underdog, -102 on the moneyline, while San Francisco is a -116 favorite despite being on the road.

Giants vs Twins Spread

• The Giants are at the Twins and are favored by 1.5 runs (+138 to cover) on the runline. Minnesota is -166 to cover.

Giants vs Twins Over/Under

• The over/under for Giants-Twins on May 10 is 8.5. The over is -124, and the under is +102.

Bet on San Francisco Giants vs. Minnesota Twins on FanDuel today!

Giants vs Twins Betting Trends

• The Giants have won in 16, or 66.7%, of the 24 contests they have been named as odds-on favorites in this year.
• This season San Francisco has come away with a win 15 times in 23 chances when named as a favorite of at least -116 on the moneyline.
• The Giants' games have gone over the total in 22 of their 39 opportunities.
• The Giants are 19-20-0 against the spread in their 39 games with a line set by sportsbooks this season.
• The Twins have been the underdog on the moneyline 11 total times this season. They've gone 4-7 in those games.
• When playing as a moneyline underdog with odds of -102 or longer, Minnesota has a record of 3-5 (37.5%).
• The Twins have had an over/under set by bookmakers 38 times, and have combined with opponents to go over the total in 13 of those games (13-22-3).
• The Twins have a 20-18-0 record against the spread this season.

Giants Player Leaders

• Jung Hoo Lee leads San Francisco in slugging percentage (.476) and total hits (43) this season. He's batting .293 with an on-base percentage of .344.
• Among qualifying hitters, he is 26th in batting average, his on-base percentage ranks 59th, and he is 38th in slugging.
• Matt Chapman is hitting .222 with five doubles, eight home runs and 29 walks. He's slugging .437 with an on-base percentage of .360.
• He is 125th in batting average, 45th in on-base percentage and 60th in slugging among qualifying hitters.
• Wilmer Flores is batting .250 with a .419 slugging percentage and 33 RBI this year.
• Michael Yastrzemski leads San Francisco with an OBP of .377 this season while batting .271 with 19 walks and 18 runs scored.

Twins Player Leaders

• Byron Buxton has accumulated 39 hits with a .550 slugging percentage, both team-high numbers for the Twins. He's batting .279 and with an on-base percentage of .322.
• Including all qualified hitters, he is 43rd in batting average, while his on-base percentage ranks 86th and he is 12th in slugging.
• Ty France paces his team with a .344 OBP, and has a club-best .397 slugging percentage. He has a batting average of .277.
• Including all qualifying hitters, his batting average places him 46th, his on-base percentage is 59th, and he is 94th in slugging.
• Trevor Larnach has two doubles, five home runs and 16 walks while batting .225.
• Harrison Bader is batting .289 with four doubles, four home runs and 12 walks.

Giants vs Twins Head to Head

• 5/9/2025: 3-1 MIN (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/14/2024: 3-2 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 7/13/2024: 4-2 MIN (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/12/2024: 7-1 SF (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/24/2023: 7-1 MIN (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 5/23/2023: 4-3 SF (Favorite: Twins, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 5/22/2023: 4-1 SF (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 8/28/2022: 8-3 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 8/27/2022: 3-2 MIN (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 8/26/2022: 9-0 MIN (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +116)

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