Astros vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for May 10

Odds updated as of 6:11 p.m.

The Houston Astros versus the Cincinnati Reds is on the MLB schedule for Saturday.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Astros vs Reds Game Info

• Houston Astros (19-18) vs. Cincinnati Reds (19-21)
• Date: Saturday, May 10, 2025
• Time: 7:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and FDSOH

Astros vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-196) | CIN: (+164)
• Spread: HOU: -1.5 (+116) | CIN: +1.5 (-140)
• Total: 7.5 -- Over: (-104) | Under: (-118)

Astros vs Reds Probable Starting Pitchers

Probable Pitchers: Lance McCullers (Astros) - 0-0, 0.00 ERA vs Brady Singer (Reds) - 4-2, 3.66 ERA

The Astros will give the nod to Lance McCullers and the Reds will counter with Brady Singer (4-2, 3.66 ERA). McCullers and his team failed to cover the spread in his only opportunity this season as a starter. McCullers' team lost his only start as a favorite this season. The Reds are 4-3-0 ATS in Singer's seven starts that had a set spread. The Reds are 2-1 in Singer's three starts this season that they were the moneyline underdog.

Astros vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (51.1%)

Astros vs Reds Moneyline

• Looking at the moneyline for Reds-Astros, Cincinnati is the underdog at +164, and Houston is -196 playing at home.

Astros vs Reds Spread

• The Astros are 1.5-run home favorites on the runline against the Reds. The Astros are +116 to cover, and the Reds are -140.

Astros vs Reds Over/Under

• A combined run total of 7.5 has been set for Astros-Reds on May 10, with the over at -104 and the under at -118.

Bet on Houston Astros vs. Cincinnati Reds on FanDuel today!

Astros vs Reds Betting Trends

• The Astros have won in 14, or 53.8%, of the 26 contests they have been named as odds-on favorites in this year.
• Houston has a record of 2-1 in contests when sportsbooks favor them by -196 or more on the moneyline.
• The Astros and their opponents have gone over the total this season in 16 of their 37 opportunities.
• The Astros are 21-16-0 against the spread in their 37 games with a line set by sportsbooks this season.
• The Reds have won nine of the 22 games they were listed as the moneyline underdog this season (40.9%).
• Cincinnati has played as a moneyline underdog of +164 or longer in only two games this season, which it lost both.
• The Reds have played in 39 games with a set over/under, and have combined with their opponents to go over the total 17 times (17-21-1).
• The Reds have a 20-19-0 record ATS this season.

Astros Player Leaders

• Jeremy Pena leads Houston with 39 hits and a team-best slugging percentage of .429. He's batting .279 with an on-base percentage of .338.
• He is 43rd in batting average, 67th in on-base percentage, and 63rd in slugging among all qualified hitters in the majors.
• Pena hopes to build on a two-game hitting streak in this matchup. During his last five outings he is batting .250 with a double, a home run and five RBIs.
• Isaac Paredes leads Houston with an OBP of .365 this season while batting .256 with 21 walks and 15 runs scored. He's slugging .391.
• He ranks 72nd in batting average, 40th in on-base percentage and 98th in slugging in MLB.
• Paredes enters this game looking to extend his two-game hit streak. During his last five outings he is batting .278 with a double, four walks and two RBIs.
• Jose Altuve has 38 hits this season and has a slash line of .259/.304/.374.
• Altuve has picked up a hit in two straight games. In his last five games he is batting .200 with two doubles and a walk.
• Jake Meyers has been key for Houston with 31 hits, an OBP of .351 plus a slugging percentage of .423.
• Meyers heads into this game on a nine-game hitting streak. During his last 10 games he is batting .382 with a double, a triple, two home runs, four walks and eight RBIs.

Reds Player Leaders

• Elly De La Cruz is batting .252 with five doubles, five home runs and 17 walks. He's slugging .381 with an on-base percentage of .331.
• Including all the qualified hitters in the big leagues, his batting average ranks 78th, his on-base percentage ranks 78th, and he is 104th in slugging.
• TJ Friedl is slugging .383 to lead his team. He has a batting average of .268 with an on-base percentage of .343.
• He ranks 59th in batting average, 61st in on-base percentage and 102nd in slugging percentage in MLB.
• Gavin Lux has 36 hits with a .385 on-base percentage, leading the Reds in both statistics.
• Jose Trevino is hitting .310 with nine doubles, three home runs and five walks.

Astros vs Reds Head to Head

• 5/9/2025: 3-0 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 9/5/2024: 1-0 CIN (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 9/4/2024: 12-5 CIN (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/2/2024: 5-3 CIN (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 6/18/2023: 9-7 CIN (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 6/17/2023: 10-3 CIN (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 6/16/2023: 2-1 CIN (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -178, Underdog Moneyline: +150)

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