Astros vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for May 10

Odds updated as of 2:11 a.m.

On Saturday in MLB, the Houston Astros are playing the Cincinnati Reds.

All the information you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Astros vs Reds Game Info

• Houston Astros (19-18) vs. Cincinnati Reds (19-21)
• Date: Saturday, May 10, 2025
• Time: 7:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and FDSOH

Astros vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-196) | CIN: (+164)
• Spread: HOU: -1.5 (+116) | CIN: +1.5 (-140)
• Total: 7.5 -- Over: (-104) | Under: (-118)

Astros vs Reds Probable Starting Pitchers

Probable Pitchers: Lance McCullers (Astros) - 0-0, 0.00 ERA vs Brady Singer (Reds) - 4-2, 3.66 ERA

This contest's pitching matchup is set, as the Astros will send Lance McCullers to the mound, while Brady Singer (4-2) will get the nod for the Reds. McCullers and his team failed to cover the spread in his only opportunity this season as a starter. McCullers' team lost his only start as a favorite this season. The Reds have gone 4-3-0 ATS in Singer's seven starts that had a set spread. The Reds are 2-1 in Singer's three starts this season that they were the underdog on the moneyline.

Astros vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (50.2%)

Astros vs Reds Moneyline

• Looking at the moneyline for Reds-Astros, Cincinnati is the underdog at +164, and Houston is -196 playing at home.

Astros vs Reds Spread

• The Astros are favored by 1.5 runs at home versus the Reds. The Astros are +116 to cover the spread, while the Reds are -140.

Astros vs Reds Over/Under

• An over/under of 7.5 has been set for Astros-Reds on May 10, with the over being -104 and the under -118.

Bet on Houston Astros vs. Cincinnati Reds on FanDuel today!

Astros vs Reds Betting Trends

• The Astros have been favorites in 26 games this season and have come away with the win 14 times (53.8%) in those contests.
• Houston has a record of 2-1 in contests when oddsmakers favor them by -196 or more on the moneyline.
• The Astros and their opponents have hit the over in 16 of their 37 games with a total set by oddsmakers this season.
• The Astros are 21-16-0 against the spread in their 37 games with a line set by sportsbooks this season.
• The Reds have won nine of the 22 games they were the moneyline underdog this season (40.9%).
• Cincinnati has played as a moneyline underdog of +164 or longer in only two games this season, which it lost both.
• The Reds have had an over/under set by oddsmakers 39 times, and have combined with opponents to go over the total in 17 of those games (17-21-1).
• The Reds have put together a 20-19-0 record ATS this season (covering 51.3% of the time).

Astros Player Leaders

• Jeremy Pena leads Houston with 39 hits and a team-best slugging percentage of .429. He's batting .279 with an on-base percentage of .338.
• He ranks 43rd in batting average, 67th in on-base percentage, and 63rd in slugging among qualified hitters in baseball.
• Pena has recorded a base hit in two straight games. In his last five games he is batting .250 with a double, a home run and five RBIs.
• Isaac Paredes leads Houston with an OBP of .365 this season while batting .256 with 21 walks and 15 runs scored. He's slugging .391.
• He ranks 72nd in batting average, 40th in on-base percentage and 98th in slugging in the major leagues.
• Paredes brings a two-game streak with at least one hit into this one. During his last five outings he is hitting .278 with a double, four walks and two RBIs.
• Jose Altuve has 38 hits this season and has a slash line of .259/.304/.374.
• Altuve enters this matchup with two games in a row with at least one hit. During his last five outings he is batting .200 with two doubles and a walk.
• Jake Meyers is batting .298 with a .351 OBP and 13 RBI for Houston this season.
• Meyers enters this matchup on a nine-game hitting streak. During his last 10 games he is hitting .382 with a double, a triple, two home runs, four walks and eight RBIs.

Reds Player Leaders

• Elly De La Cruz is hitting .252 with five doubles, five home runs and 17 walks. He's slugging .381 with an on-base percentage of .331.
• Including all qualifying hitters, he is 78th in batting average, while his on-base percentage ranks 78th and he is 104th in slugging.
• TJ Friedl is slugging .383 to lead his team. He has a batting average of .268 with an on-base percentage of .343.
• He ranks 59th in batting average, 61st in on-base percentage and 102nd in slugging percentage in the majors.
• Gavin Lux has put up an on-base percentage of .385 and has 36 hits, both team-high numbers for the Reds.
• Jose Trevino is batting .310 with nine doubles, three home runs and five walks.

Astros vs Reds Head to Head

• 5/9/2025: 3-0 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 9/5/2024: 1-0 CIN (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 9/4/2024: 12-5 CIN (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/2/2024: 5-3 CIN (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 6/18/2023: 9-7 CIN (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 6/17/2023: 10-3 CIN (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 6/16/2023: 2-1 CIN (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -178, Underdog Moneyline: +150)

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