Astros vs Blue Jays Prediction, Odds, Moneyline, Spread & Over/Under for April 21

Odds updated as of 8:12 p.m.

Monday's slate in the MLB includes a matchup between the Houston Astros and the Toronto Blue Jays.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info regarding this game.

Astros vs Blue Jays Game Info

• Houston Astros (10-11) vs. Toronto Blue Jays (12-10)
• Date: Monday, April 21, 2025
• Time: 8:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and SN1

Astros vs Blue Jays Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-136) | TOR: (+116)
• Spread: HOU: -1.5 (+158) | TOR: +1.5 (-192)
• Total: 7.5 -- Over: (-106) | Under: (-114)

Astros vs Blue Jays Probable Starting Pitchers

Probable Pitchers: Hunter Brown (Astros) - 2-1, 1.50 ERA vs Kevin Gausman (Blue Jays) - 2-1, 2.49 ERA

The Astros will call on Hunter Brown (2-1) versus the Blue Jays and Kevin Gausman (2-1). Brown and his team are 2-2-0 ATS this season when he starts. Brown's team has been victorious in 33.3% of the games he's started as the moneyline favorite with a record of 1-2. The Blue Jays have a 3-1-0 ATS record in Gausman's four starts that had a set spread. The Blue Jays have a 2-1 record in Gausman's three starts this season when they were the underdog on the moneyline.

Astros vs Blue Jays Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (56.4%)

Astros vs Blue Jays Moneyline

• The moneyline numbers for Astros vs. Blue Jays reveal Houston as the favorite (-136) and Toronto as the underdog (+116) on the road.

Astros vs Blue Jays Spread

• The Blue Jays are at the Astros, and are +1.5 on the runline. The Blue Jays are +158 to cover the spread, and the Astros are -192.

Astros vs Blue Jays Over/Under

• The over/under for Astros-Blue Jays on April 21 is 7.5. The over is -106, and the under is -114.

Bet on Houston Astros vs. Toronto Blue Jays on FanDuel today!

Astros vs Blue Jays Betting Trends

• The Astros have won in six, or 46.2%, of the 13 contests they have been named as odds-on favorites in this year.
• This year Houston has won three of six games when listed as at least -136 on the moneyline.
• The Astros' games have gone over the total in eight of their 21 opportunities.
• The Astros are 11-10-0 against the spread in their 21 games with a line set by sportsbooks this season.
• The Blue Jays have been the moneyline underdog 15 total times this season. They've gone 7-8 in those games.
• In games it has played as a moneyline underdog with odds of +116 or longer, Toronto has a 2-1 record (winning 66.7% of its games).
• In the 22 games oddsmakers have set an over/under for the Blue Jays, they have combined with opponents to go over the total nine times (9-12-1).
• The Blue Jays have gone 16-6-0 against the spread this season.

Astros Player Leaders

• Jeremy Pena is batting .224 with three doubles, three home runs and seven walks. He has an on-base percentage of .302 and a slugging percentage of .382.
• Among qualifying hitters in baseball, he ranks 110th in batting average, 111th in on-base percentage, and 98th in slugging.
• Pena hopes to build on an 11-game hitting streak in this matchup. During his last 10 outings he is hitting .297 with three doubles, a home run, four walks and five RBI.
• Jose Carlos Altuve leads Houston in slugging percentage (.419) and total hits (26) this season. He's batting .302 with an on-base percentage of .330.
• Among all qualified hitters, he is 31st in batting average, 79th in on-base percentage and 79th in slugging percentage.
• Isaac Paredes is batting .231 with a .359 slugging percentage and 11 RBI this year.
• Jake Meyers has 18 hits this season and a team-best OBP of .354.

Blue Jays Player Leaders

• Vladimir Guerrero Jr. is batting .305 with six doubles, a home run and 14 walks. He's slugging .415 with an on-base percentage of .408.
• Including all qualifying hitters, he is 25th in batting average, while his on-base percentage is 12th and he is 82nd in slugging.
• Bo Joseph Bichette paces his team with a .396 slugging percentage. He has a batting average of .313 with an on-base percentage of .356.
• His batting average is 21st among all qualified players, his on-base percentage ranks 50th, and he is 91st in slugging.
• Andres Gimenez is batting .205 with four doubles, three home runs and eight walks.
• George Springer's 21 hits and .414 on-base percentage both lead his team.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!