Astros vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for May 27

Odds updated as of 2:13 p.m.

MLB action on Tuesday includes the Houston Astros taking on the Athletics.

All the information you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Astros vs Athletics Game Info

• Houston Astros (28-25) vs. Athletics (23-31)
• Date: Tuesday, May 27, 2025
• Time: 8:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and NBCS-CA

Astros vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-240) | OAK: (+198)
• Spread: HOU: -1.5 (-114) | OAK: +1.5 (-105)
• Total: 8 -- Over: (-112) | Under: (-108)

Astros vs Athletics Probable Starting Pitchers

Probable Pitchers: Hunter Brown (Astros) - 6-3, 2.04 ERA vs JP Sears (Athletics) - 4-4, 4.00 ERA

The probable starters are Hunter Brown (6-3) for the Astros and JP Sears (4-4) for the Athletics. Brown and his team have a record of 7-3-0 against the spread when he starts. When Brown starts a game and his team is the favorite on the moneyline, they have a record of 5-3. The Athletics are 6-4-0 against the spread when Sears starts. The Athletics have a 1-3 record in Sears' four starts this season when they were the underdog on the moneyline.

Astros vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (67%)

Astros vs Athletics Moneyline

• The Astros vs Athletics moneyline has the Astros as a -240 favorite, while the Athletics are a +198 underdog on the road.

Astros vs Athletics Spread

• The Astros are 1.5-run favorites on the runline against the Athletics. The Astros are -114 to cover, while the Athletics are -105 to cover.

Astros vs Athletics Over/Under

• Astros versus Athletics on May 27 has an over/under of 8 runs, with the odds on the over -112 and the under set at -108.

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Astros vs Athletics Betting Trends

• The Astros have won in 18, or 52.9%, of the 34 contests they have been named as odds-on favorites in this year.
• The Astros have been named as a favorite of -240 or more just one time this season and left with a loss in that game.
• The Astros and their opponents have hit the over in 21 of their 53 games with a total this season.
• In 53 games with a line this season, the Astros have a mark of 29-24-0 against the spread.
• The Athletics have been the moneyline underdog 34 total times this season. They've gone 12-22 in those games.
• The Athletics have played as a moneyline underdog of +198 or longer in only two games this season, which they lost both.
• The Athletics have played in 54 games with a set over/under, and have combined with their opponents to go over the total 29 times (29-22-3).
• The Athletics have a 26-28-0 record ATS this season (covering 48.1% of the time).

Astros Player Leaders

• Isaac Paredes leads Houston in OBP (.377) and total hits (54) this season. He's batting .276 batting average while slugging .490.
• Among qualified batters in baseball, he is 43rd in batting average, 24th in on-base percentage, and 36th in slugging.
• Paredes will look for his fourth straight game with a hit in this matchup. In his last five games he is hitting .364 with a double, three home runs and six RBIs.
• Jeremy Pena leads Houston in slugging percentage (.435) thanks to 15 extra-base hits. He's batting .295 with an on-base percentage of .362.
• Among qualified hitters, his batting average ranks him 18th, his on-base percentage 37th, and his slugging percentage 67th.
• Pena has picked up a hit in two straight games. In his last five games he is hitting .222 with a triple, a walk and two RBIs.
• Jose Altuve has collected 52 base hits, an OBP of .309 and a slugging percentage of .376 this season.
• Altuve takes a four-game hitting streak into this matchup. During his last five outings he is batting .400 with two home runs, two walks and four RBIs.
• Jake Meyers has been key for Houston with 48 hits, an OBP of .358 plus a slugging percentage of .413.

Athletics Player Leaders

• Jacob Wilson has accumulated an on-base percentage of .393, a slugging percentage of .495, and has 70 hits, all club-bests for the Athletics (while batting .350).
• Including all the qualified hitters in MLB, he is third in batting average, 10th in on-base percentage and 32nd in slugging percentage.
• Brent Rooker has eight doubles, a triple, 12 home runs and 20 walks while hitting .255. He's slugging .468 with an on-base percentage of .324.
• Including all qualified hitters, he is 84th in batting average, 89th in on-base percentage and 45th in slugging percentage.
• Tyler Soderstrom has 10 doubles, 10 home runs and 20 walks while batting .269.
• Shea Langeliers is hitting .241 with six doubles, nine home runs and 18 walks.

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