Astros vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for May 27

Odds updated as of 8:12 p.m.

Tuesday's slate in the MLB includes a matchup between the Houston Astros and the Athletics.

All the info you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Astros vs Athletics Game Info

• Houston Astros (28-25) vs. Athletics (23-31)
• Date: Tuesday, May 27, 2025
• Time: 8:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and NBCS-CA

Astros vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-126) | OAK: (+108)
• Spread: HOU: -1.5 (+150) | OAK: +1.5 (-182)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Astros vs Athletics Probable Starting Pitchers

Probable Pitchers: Hunter Brown (Astros) - 6-3, 2.04 ERA vs JP Sears (Athletics) - 4-4, 4.00 ERA

The Astros will give the nod to Hunter Brown (6-3, 2.04 ERA), who is eyeing win No. 7 on the season, and the Athletics will turn to JP Sears (4-4, 4.00 ERA). When Brown starts, his team is 7-3-0 against the spread this season. When Brown starts a game and his team is the favorite on the moneyline, they have a record of 5-3. The Athletics have a 6-4-0 record against the spread in Sears' starts. The Athletics have been the underdog on the moneyline in four of Sears' starts this season, and they went 1-3 in those games.

Astros vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (55.5%)

Astros vs Athletics Moneyline

• The Astros vs Athletics moneyline has the Astros as a -126 favorite, while the Athletics are a +108 underdog on the road.

Astros vs Athletics Spread

• The Astros are 1.5-run favorites on the runline against the Athletics. The Astros are +150 to cover, while the Athletics are -182 to cover.

Astros vs Athletics Over/Under

• The over/under for the Astros versus Athletics game on May 27 has been set at 8.5, with -105 odds on the over and -115 odds on the under.

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Astros vs Athletics Betting Trends

• The Astros have been favorites in 34 games this season and have come away with the win 18 times (52.9%) in those contests.
• This season, the Astros have come away with a win 12 times in 22 chances when named as a favorite of at least -126 or shorter on the moneyline.
• The Astros and their opponents have hit the over in 21 of their 53 games with a total this season.
• The Astros are 29-24-0 against the spread in their 53 games that had a posted line this season.
• The Athletics have been the underdog on the moneyline 34 total times this season. They've finished 12-22 in those games.
• The Athletics have a record of 11-20 in games they have played as a moneyline underdog with odds of +108 or longer (35.5%).
• The Athletics have combined with their opponents to hit the over on the total 29 times this season for a 29-22-3 record against the over/under.
• The Athletics have collected a 26-28-0 record ATS this season (covering 48.1% of the time).

Astros Player Leaders

• Isaac Paredes has 54 hits and an OBP of .377, both of which rank first among Houston hitters this season. He has a .276 batting average and a slugging percentage of .490.
• He is 43rd in batting average, 24th in on-base percentage, and 36th in slugging among qualifying hitters in MLB.
• Paredes will look for his fourth straight game with a hit in this matchup. During his last five outings he is batting .364 with a double, three home runs and six RBIs.
• Jeremy Pena leads Houston in slugging percentage (.435) thanks to 15 extra-base hits. He's batting .295 with an on-base percentage of .362.
• Among qualifiers, he ranks 18th in batting average, 37th in on-base percentage and 67th in slugging percentage.
• Pena enters this game looking to extend his two-game hit streak. During his last five outings he is hitting .222 with a triple, a walk and two RBIs.
• Jose Altuve has collected 52 base hits, an OBP of .309 and a slugging percentage of .376 this season.
• Altuve has recorded at least one base hit in four games in a row. During his last five outings he is batting .400 with two home runs, two walks and four RBIs.
• Jake Meyers is batting .300 with a .358 OBP and 16 RBI for Houston this season.

Athletics Player Leaders

• Jacob Wilson has 70 hits with a .393 on-base percentage and a .495 slugging percentage, all club-bests for the Athletics. He's batting .350.
• Including all qualified players in the majors, he is third in batting average, 10th in on-base percentage and 32nd in slugging percentage.
• Brent Rooker has eight doubles, a triple, 12 home runs and 20 walks while batting .255. He's slugging .468 with an on-base percentage of .324.
• Including all qualifying players, his batting average places him 84th, his on-base percentage is 89th, and he is 45th in slugging.
• Tyler Soderstrom is batting .269 with 10 doubles, 10 home runs and 20 walks.
• Shea Langeliers is batting .241 with six doubles, nine home runs and 18 walks.

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