Astros vs Angels Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 27

Odds updated as of 9:12 p.m.

The MLB's Saturday schedule includes the Houston Astros taking on the Los Angeles Angels.

We've got you covered, in terms of the most important info regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Astros vs Angels Game Info

• Houston Astros (85-75) vs. Los Angeles Angels (72-88)
• Date: Saturday, September 27, 2025
• Time: 9:38 p.m. ET
• Venue: Angel Stadium -- Anaheim, California
• Coverage: FDSW and SCHN

Astros vs Angels Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-144) | LAA: (+122)
• Spread: HOU: -1.5 (+114) | LAA: +1.5 (-137)
• Total: 9 -- Over: (-105) | Under: (-115)

Astros vs Angels Probable Starting Pitchers

Probable Pitchers: A.J. Blubaugh (Astros) - 3-1, 1.93 ERA vs Caden Dana (Angels) - 0-3, 6.39 ERA

This contest's pitching matchup is set, as the Astros will send A.J. Blubaugh (3-1) to the mound, while Caden Dana (0-3) will get the nod for the Angels. Blubaugh has a record of 1-1-0 ATS in two starts with a spread this season. Blubaugh's team lost his only start as a favorite this season. The Angels have a 1-3-0 ATS record in Dana's four starts with a set spread. The Angels have a 1-2 record in Dana's three starts this season when they were the moneyline underdog.

Astros vs Angels Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (60.8%)

Astros vs Angels Moneyline

• Los Angeles is the underdog, +122 on the moneyline, while Houston is a -144 favorite despite being on the road.

Astros vs Angels Spread

• The Astros are 1.5-run road favorites on the runline against the Angels. The Astros are +114 to cover, and the Angels are -137.

Astros vs Angels Over/Under

• The over/under for Astros-Angels on Sept. 27 is 9. The over is -105, and the under is -115.

Bet on Houston Astros vs. Los Angeles Angels on FanDuel today!

Astros vs Angels Betting Trends

• The Astros have been chosen as favorites in 97 games this year and have walked away with the win 51 times (52.6%) in those games.
• Houston has a record of 21-16 in contests when bookmakers favor them by -144 or more on the moneyline.
• The Astros and their opponents have hit the over in 72 of their 159 games with a total set by oddsmakers this season.
• The Astros are 78-81-0 against the spread in their 159 games with a line set by sportsbooks this season.
• The Angels have been the moneyline underdog 119 total times this season. They've finished 52-67 in those games.
• In games it has played as a moneyline underdog with odds of +122 or longer, Los Angeles has a 31-40 record (winning 43.7% of its games).
• The Angels have combined with opponents to go over the total 84 times this season for an 84-69-5 record against the over/under.
• The Angels have put together an 83-75-0 record against the spread this season (covering 52.5% of the time).

Astros Player Leaders

• Jose Altuve leads Houston in slugging percentage (.441) thanks to 51 extra-base hits. He has a .264 batting average and an on-base percentage of .328.
• Among all qualified hitters in the majors, his batting average ranks 53rd, his on-base percentage ranks 75th, and he is 64th in slugging.
• Jeremy Pena leads Houston with 150 hits and an OBP of .363 this season. He's batting .304 and slugging .477.
• He is fifth in batting average, 18th in on-base percentage and 32nd in slugging among qualified hitters.
• Yainer Diaz has collected 136 base hits, an OBP of .283 and a slugging percentage of .413 this season.
• Carlos Correa has been key for Houston with 148 hits, an OBP of .333 plus a slugging percentage of .403.
• Correa takes a three-game hitting streak into this game. In his last five games he is batting .294 with two doubles, four walks and two RBIs.

Angels Player Leaders

• Taylor Ward has a slugging percentage of .476, a team-high for the Angels. He's batting .227 with an on-base percentage of .316.
• Including all qualifying hitters in MLB, he is 139th in batting average, 100th in on-base percentage and 35th in slugging percentage.
• Nolan Schanuel is hitting .264 with 23 doubles, a triple, 12 home runs and 59 walks. He's slugging .389 with an on-base percentage of .353.
• His batting average is 53rd among all qualified players, his on-base percentage is 31st, and he is 116th in slugging.
• Jo Adell has totaled 122 hits, a team-high for the Angels.
• Mike Trout leads his team with a .356 OBP.

Astros vs Angels Head to Head

• 9/26/2025: 4-3 LAA (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 9/1/2025: 8-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 8/31/2025: 3-0 LAA (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 8/30/2025: 4-1 LAA (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 8/29/2025: 2-0 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/22/2025: 8-7 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/21/2025: 9-1 LAA (Favorite: Angels, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/20/2025: 3-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 4/13/2025: 7-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 4/12/2025: 4-1 LAA (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -164, Underdog Moneyline: +138)

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