Astros vs Angels Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 27

Odds updated as of 9:11 a.m.

The Houston Astros versus the Los Angeles Angels is on the MLB schedule for Saturday.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Astros vs Angels Game Info

• Houston Astros (85-75) vs. Los Angeles Angels (72-88)
• Date: Saturday, September 27, 2025
• Time: 9:38 p.m. ET
• Venue: Angel Stadium -- Anaheim, California
• Coverage: FDSW and SCHN

Astros vs Angels Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-148) | LAA: (+126)
• Spread: HOU: -1.5 (+110) | LAA: +1.5 (-132)
• Total: 9 -- Over: (-100) | Under: (-122)

Astros vs Angels Probable Starting Pitchers

Probable Pitchers: A.J. Blubaugh (Astros) - 3-1, 1.93 ERA vs Caden Dana (Angels) - 0-3, 6.39 ERA

This contest's pitching matchup is set, as the Astros will send A.J. Blubaugh (3-1) to the mound, while Caden Dana (0-3) will answer the bell for the Angels. Blubaugh has a record of 1-1-0 ATS in two starts with a spread this season. Blubaugh's team lost his only start as a favorite this season. The Angels have gone 1-3-0 against the spread when Dana starts. The Angels have been the moneyline underdog in three of Dana's starts this season, and they went 1-2 in those matchups.

Astros vs Angels Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (60.8%)

Astros vs Angels Moneyline

• Houston is the favorite, -148 on the moneyline, while Los Angeles is a +126 underdog despite being at home.

Astros vs Angels Spread

• The Angels are at +1.5 on the runline against the Astros. The Angels are -132 to cover the spread, and the Astros are +110.

Astros vs Angels Over/Under

• A total of 9 runs has been set for the Astros-Angels contest on Sept. 27, with the over available at -100 and the under at -122.

Bet on Houston Astros vs. Los Angeles Angels on FanDuel today!

Astros vs Angels Betting Trends

• The Astros have been favorites in 97 games this season and have come away with the win 51 times (52.6%) in those contests.
• Houston has a record of 19-16 when favored by -148 or more this year.
• The Astros' games have gone over the total in 72 of their 159 opportunities.
• The Astros are 78-81-0 against the spread in their 159 games with a line set by sportsbooks this season.
• The Angels are 52-67 in games they were listed as the moneyline underdog (winning 43.7% of those games).
• When it has played as a moneyline underdog with odds of +126 or longer, Los Angeles has a 29-35 record (winning 45.3% of its games).
• In the 158 games oddsmakers have set an over/under for the Angels, they have combined with opponents to go over the total 84 times (84-69-5).
• The Angels have gone 83-75-0 ATS this season.

Astros Player Leaders

• Jose Altuve leads Houston in slugging percentage (.441) thanks to 51 extra-base hits. He has a .264 batting average and an on-base percentage of .328.
• Among all qualified hitters, he ranks 54th in batting average, his on-base percentage ranks 77th, and he is 65th in slugging.
• Jeremy Pena has 150 hits and an OBP of .363, both of which lead the Astros this season. He's batting .304 and slugging .477.
• His batting average ranks fifth among qualified players, his on-base percentage 18th, and his slugging percentage 32nd.
• Yainer Diaz has 136 hits this season and has a slash line of .255/.283/.413.
• Carlos Correa has 13 home runs, 52 RBI and a batting average of .276 this season.
• Correa heads into this matchup on a three-game hitting streak. During his last five outings he is hitting .294 with two doubles, four walks and two RBIs.

Angels Player Leaders

• Taylor Ward has accumulated a team-high .476 slugging percentage. He's batting .227 with an on-base percentage of .316.
• Including all qualified hitters, he ranks 140th in batting average, while his on-base percentage is 102nd and he is 33rd in slugging.
• Nolan Schanuel is hitting .264 with 23 doubles, a triple, 12 home runs and 59 walks. He's slugging .389 with an on-base percentage of .353.
• Including all qualified players, he is 54th in batting average, 32nd in on-base percentage and 118th in slugging percentage.
• Jo Adell leads the Angels with 122 hits.
• Mike Trout paces his team with a .356 OBP.

Astros vs Angels Head to Head

• 9/26/2025: 4-3 LAA (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 9/1/2025: 8-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 8/31/2025: 3-0 LAA (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 8/30/2025: 4-1 LAA (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 8/29/2025: 2-0 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/22/2025: 8-7 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/21/2025: 9-1 LAA (Favorite: Angels, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/20/2025: 3-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 4/13/2025: 7-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 4/12/2025: 4-1 LAA (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -164, Underdog Moneyline: +138)

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