Yankees vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for April 21

Odds updated as of 6:11 p.m.

The MLB schedule on Monday includes the New York Yankees facing the Cleveland Guardians.

We've got you covered, in terms of the most important info about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Yankees vs Guardians Game Info

• New York Yankees (14-8) vs. Cleveland Guardians (12-9)
• Date: Monday, April 21, 2025
• Time: 6:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CLEG and YES

Yankees vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYY: (-124) | CLE: (+106)
• Spread: NYY: -1.5 (+136) | CLE: +1.5 (-164)
• Total: 8.5 -- Over: (-115) | Under: (-105)

Yankees vs Guardians Probable Starting Pitchers

Probable Pitchers: Clarke Schmidt (Yankees) - 0-0, 4.76 ERA vs Gavin Williams (Guardians) - 1-1, 4.58 ERA

The Yankees will give the ball to Clarke Schmidt and the Guardians will turn to Gavin Williams (1-1, 4.58 ERA). Schmidt and his team failed to cover the spread in his only opportunity this season as a starter. Schmidt's team won his only start as a favorite this season. When Williams starts, the Guardians have gone 2-2-0 against the spread. The Guardians were named the moneyline underdog for two Williams starts this season -- they lost both.

Yankees vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (51.1%)

Yankees vs Guardians Moneyline

• The Yankees vs Guardians moneyline has New York as a -124 favorite, while Cleveland is a +106 underdog at home.

Yankees vs Guardians Spread

• The Guardians are hosting the Yankees, and are +1.5 on the runline. The Guardians are +136 to cover the spread, and the Yankees are -164.

Yankees vs Guardians Over/Under

• The over/under for the Yankees versus Guardians game on April 21 has been set at 8.5, with -115 odds on the over and -105 odds on the under.

Bet on New York Yankees vs. Cleveland Guardians on FanDuel today!

Yankees vs Guardians Betting Trends

• The Yankees have been favorites in 18 games this season and have come away with the win 13 times (72.2%) in those contests.
• This year New York has won 12 of 16 games when listed as at least -124 on the moneyline.
• The Yankees' games have gone over the total in 11 of their 22 opportunities.
• In 22 games with a line this season, the Yankees have a mark of 11-11-0 against the spread.
• The Guardians have won 41.7% of the games this season they were the underdog on the moneyline (5-7).
• When playing as a moneyline underdog with odds of +106 or longer, Cleveland has a 3-5 record (winning just 37.5% of its games).
• The Guardians have played in 21 games with a set over/under, and have combined with their opponents to go over the total 11 times (11-9-1).
• The Guardians have a 9-12-0 record against the spread this season (covering 42.9% of the time).

Yankees Player Leaders

• Aaron Judge has 32 hits and an OBP of .495 to go with a slugging percentage of .707. All three of those stats are best among New York hitters this season. He has a .390 batting average, as well.
• Among the qualified hitters in MLB, his batting average ranks first, his on-base percentage ranks first, and he is second in slugging.
• Judge will look for his third straight game with a hit in this contest. During his last five outings he is hitting .421 with a double, a home run, three walks and five RBI.
• Ben Rice is batting .292 with three doubles, a triple, five home runs and 10 walks, while slugging .600 with an on-base percentage of .403.
• His batting average is 41st among qualified players, his on-base percentage 19th, and his slugging percentage 11th.
• Anthony Volpe is batting .213 with a .425 slugging percentage and 15 RBI this year.
• Volpe takes a two-game hitting streak into this matchup. In his last five games he is hitting .200 with two doubles, a walk and two RBI.
• Paul Goldschmidt has one home run, seven RBI and a batting average of .361 this season.
• Goldschmidt has hit safely in five games in a row. In his last five games he is batting .400 with two walks and an RBI.

Guardians Player Leaders

• Steven Kwan has racked up an on-base percentage of .385 and a slugging percentage of .494. Both lead the Guardians. He's batting .325.
• Including all the qualified hitters in the big leagues, he ranks 14th in batting average, 30th in on-base percentage and 37th in slugging percentage.
• Kwan hopes to build on a four-game hitting streak in this matchup. During his last five outings he is hitting .300 with a double, a home run, two walks and three RBI.
• Jose Ramirez is batting .268 with four doubles, four home runs and eight walks. He's slugging .493 with an on-base percentage of .333.
• His batting average ranks 65th among all qualified players, his on-base percentage ranks 74th, and he is 39th in slugging.
• Kyle Manzardo has put up 14 hits, a team-best for the Guardians.
• Gabriel Arias has three doubles, four home runs and five walks while batting .277.

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