Yankees vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 18

Odds updated as of 9:11 p.m.

MLB action on Friday includes the Arizona Diamondbacks playing the New York Yankees.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Diamondbacks vs Yankees Game Info

• Arizona Diamondbacks (80-73) vs. New York Yankees (88-64)
• Date: Friday, September 18, 2026
• Time: 9:40 p.m. ET
• Venue: Chase Field -- Phoenix, Arizona
• Coverage: Dbacks.TV and YES

Diamondbacks vs Yankees Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: ARI: (-116) | NYY: (-102)
• Spread: ARI: +1.5 (-192) | NYY: -1.5 (+158)
• Total: 7.5 -- Over: (-112) | Under: (-108)

Diamondbacks vs Yankees Probable Starting Pitchers

Probable Pitchers: Eduardo Rodríguez (Diamondbacks) - 15-6, 2.62 ERA vs Gerrit Cole (Yankees) - 8-9, 3.67 ERA

The Diamondbacks will look to Eduardo Rodriguez (15-6) against the Yankees and Gerrit Cole (8-9). Rodriguez and his team have a record of 18-12-0 against the spread when he starts. When Rodriguez starts a game and his team is the favorite on the moneyline, they have a record of 9-4. When Cole starts, the Yankees are 7-13-0 against the spread. The Yankees have been the underdog on the moneyline in four of Cole's starts this season, and they went 1-3 in those matchups.

Diamondbacks vs Yankees Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Yankees win (53.8%)

Diamondbacks vs Yankees Moneyline

• New York is a -102 underdog on the moneyline, while Arizona is a -116 favorite at home.

Diamondbacks vs Yankees Spread

• The Yankees are 1.5-run favorites against the spread for this matchup with the Diamondbacks. The Yankees are +158 to cover, while the Diamondbacks are -192 to cover as a 1.5-run underdog on the runline.

Diamondbacks vs Yankees Over/Under

• Diamondbacks versus Yankees on Sept. 18 has an over/under of 7.5 runs, with the odds on the over -112 and the under set at -108.

Bet on Arizona Diamondbacks vs. New York Yankees on FanDuel today!

Diamondbacks vs Yankees Betting Trends

• The Diamondbacks have been favorites in 64 games this season and have come away with the win 36 times (56.2%) in those contests.
• Arizona has a record of 29-24 in contests when bookmakers favor them by -116 or more on the moneyline.
• The Diamondbacks and their opponents have gone over the total this season in 64 of their 151 opportunities.
• The Diamondbacks are 78-73-0 against the spread in their 151 games that had a posted line this season.
• The Yankees have been the underdog on the moneyline 27 total times this season. They've finished 14-13 in those games.
• When playing as a moneyline underdog with odds of -102 or longer, New York has a record of 14-8 (63.6%).
• The Yankees have played in 147 games with an over/under set, and have combined with opponents to go over the total 67 times (67-76-4).
• The Yankees have put together a 76-71-0 record against the spread this season (covering 51.7% of the time).

Diamondbacks Player Leaders

• Corbin Carroll is batting .238 with 30 doubles, 16 triples, 21 home runs and 70 walks. He has an on-base percentage of .330 while slugging .465.
• He ranks 102nd in batting average, 69th in on-base percentage, and 35th in slugging among qualifying batters in baseball.
• Ketel Marte has 29 doubles, three triples, 22 home runs and 47 walks. He's batting .250 and slugging .442 with an on-base percentage of .316.
• Among all qualified, he is 77th in batting average, 93rd in on-base percentage and 54th in slugging percentage.
• Marte has picked up a hit in four games in a row. During his last five outings he is batting .217 with three doubles, a walk and an RBI.
• Gabriel Moreno leads Arizona in OBP (.385), slugging percentage (.485) and total hits (136) this season.
• Moreno enters this game with six games in a row with at least one hit. During his last 10 outings he is hitting .375 with two doubles, three home runs, four walks and six RBIs.
• Geraldo Perdomo has been key for Arizona with 133 hits, an OBP of .360 plus a slugging percentage of .362.
• Perdomo has hit safely in two games in a row. During his last five outings he is hitting .353 with four walks.

Yankees Player Leaders

• Ben Rice has a .360 on-base percentage and a .524 slugging percentage, both team-best marks for the Yankees. He's batting .262.
• Including all qualified players in the majors, he ranks 59th in batting average, 30th in on-base percentage and seventh in slugging percentage.
• Rice brings a six-game hitting streak into this game. In his last 10 games he is hitting .333 with two home runs, 10 walks and four RBIs.
• Luis Garcia paces his team with 140 hits. He has a batting average of .283 while slugging .538 with an on-base percentage of .314.
• Including all qualified hitters, his batting average places him 19th, his on-base percentage is 100th, and he is third in slugging.
• Cody Bellinger is hitting .276 with 25 doubles, three triples, 16 home runs and 58 walks.
• Jose Caballero has 12 doubles, 14 home runs and 26 walks while hitting .234.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!