Cardinals vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 18

Odds updated as of 8:11 p.m.

On Friday in MLB, the Washington Nationals are up against the St. Louis Cardinals.

We've got you covered, in terms of the most important information regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Nationals vs Cardinals Game Info

• Washington Nationals (71-82) vs. St. Louis Cardinals (75-78)
• Date: Friday, September 18, 2026
• Time: 8:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and Nationals.TV

Nationals vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: WSH: (-110) | STL: (-106)
• Spread: WSH: -1.5 (+158) | STL: +1.5 (-192)
• Total: 7.5 -- Over: (-114) | Under: (-106)

Nationals vs Cardinals Probable Starting Pitchers

Probable Pitchers: Cade Cavalli (Nationals) - 12-5, 3.12 ERA vs Kyle Leahy (Cardinals) - 10-4, 3.33 ERA

The Nationals will give the nod to Cade Cavalli (12-5) versus the Cardinals and Kyle Leahy (10-4). Cavalli's team is 17-12-0 against the spread in his starts this season. Cavalli's team has won 55.6% of his starts when they are favored on the moneyline (5-4). The Cardinals are 13-13-0 against the spread when Leahy starts. The Cardinals have a 6-9 record in Leahy's 15 starts this season when they were the moneyline underdog.

Nationals vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (50.6%)

Nationals vs Cardinals Moneyline

• Washington is a -110 favorite on the moneyline, while St. Louis is a -106 underdog at home.

Nationals vs Cardinals Spread

• The Nationals are at the Cardinals and are favored by 1.5 runs on the spread. The Nationals are +158 to cover the runline, with the Cardinals being -192.

Nationals vs Cardinals Over/Under

• The over/under for the Nationals versus Cardinals game on Sept. 18 has been set at 7.5, with -114 odds on the over and -106 odds on the under.

Bet on Washington Nationals vs. St. Louis Cardinals on FanDuel today!

Nationals vs Cardinals Betting Trends

• The Nationals have come away with 17 wins in the 31 contests they have been listed as the favorites in this season.
• Washington has a record of 17-14 when favored by -110 or more this year.
• The Nationals and their opponents have hit the over in 78 of their 149 games with a total set by oddsmakers this season.
• The Nationals have an against the spread record of 81-68-0 in 149 games with a line this season.
• The Cardinals have won 46.9% of the games this season they were the underdog on the moneyline (45-51).
• St. Louis is 45-50 (winning 47.4% of its games) when it has played as a moneyline underdog of -106 or longer.
• In the 149 games bookmakers have set an over/under for the Cardinals, they have combined with opponents to go over the total 69 times (69-73-7).
• The Cardinals have collected an 80-69-0 record against the spread this season.

Nationals Player Leaders

• C.J. Abrams leads Washington in slugging percentage (.495) thanks to 63 extra-base hits. He has a .264 batting average and an on-base percentage of .339.
• Among qualified batters in MLB, his batting average ranks 55th, his on-base percentage ranks 57th, and he is 17th in slugging.
• Abrams will look for his fifth straight game with a hit in this contest. During his last five outings he is hitting .333 with four doubles and an RBI.
• James Wood leads Washington with 127 hits and an OBP of .391 this season. He's batting .265 and slugging .518.
• Among all qualifying players, he ranks 54th in batting average, fourth in on-base percentage and ninth in slugging percentage.
• Daylen Lile has collected 143 base hits, an OBP of .304 and a slugging percentage of .438 this season.
• Lile brings a three-game hitting streak into this matchup. In his last five games he is batting .333 with a triple, a home run, a walk and four RBIs.
• Jacob Young is batting .247 with a .315 OBP and 47 RBI for Washington this season.

Cardinals Player Leaders

• Alec Burleson has a slugging percentage of .471, a team-high for the Cardinals. He's batting .284 with an on-base percentage of .350.
• Including all qualified hitters, he ranks 16th in batting average, while his on-base percentage is 44th and he is 30th in slugging.
• Burleson enters this matchup on a four-game hitting streak. In his last five games he is batting .278 with two doubles, a home run, two walks and five RBIs.
• Jordan Walker paces his team with 160 hits. He has a batting average of .278 while slugging .482 with an on-base percentage of .336.
• Including all qualifying hitters, he is 24th in batting average, 61st in on-base percentage and 24th in slugging percentage.
• Ivan Herrera has racked up a team-best .355 on-base percentage.
• JJ Wetherholt is hitting .240 with 14 doubles, 17 home runs and 63 walks.

Nationals vs Cardinals Head to Head

• 4/8/2026: 6-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 4/7/2026: 7-6 STL (Favorite: Nationals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/6/2026: 9-6 WSH (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/10/2025: 8-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/9/2025: 8-2 WSH (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/11/2025: 6-1 STL (Favorite: Nationals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/10/2025: 4-2 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/9/2025: 10-0 STL (Favorite: Nationals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 7/28/2024: 4-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 7/27/2024: 14-3 WSH (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)

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