Cardinals vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 18

Odds updated as of 4:12 a.m.

The St. Louis Cardinals versus the Washington Nationals is on the MLB schedule for Friday.

We've got you covered, in terms of the most important info regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Cardinals vs Nationals Game Info

• St. Louis Cardinals (75-78) vs. Washington Nationals (71-82)
• Date: Friday, September 18, 2026
• Time: 8:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and Nationals.TV

Cardinals vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-112) | WSH: (-104)
• Spread: STL: +1.5 (-200) | WSH: -1.5 (+164)
• Total: 7.5 -- Over: (-120) | Under: (-102)

Cardinals vs Nationals Probable Starting Pitchers

Probable Pitchers: Kyle Leahy (Cardinals) - 10-4, 3.33 ERA vs Cade Cavalli (Nationals) - 12-5, 3.12 ERA

The Cardinals will look to Kyle Leahy (10-4) versus the Nationals and Cade Cavalli (12-5). When Leahy starts, his team is 13-13-0 against the spread this season. When Leahy starts a game and his team is the favorite on the moneyline, they have a record of 5-5. The Nationals have gone 17-12-0 against the spread when Cavalli starts. The Nationals have an 8-11 record in Cavalli's 19 starts this season when they were the underdog on the moneyline.

Cardinals vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (50.5%)

Cardinals vs Nationals Moneyline

• The moneyline numbers for Cardinals vs. Nationals reveal St. Louis as the favorite (-112) and Washington as the underdog (-104) on the road.

Cardinals vs Nationals Spread

• The Nationals are 1.5-run favorites against the spread for this matchup with the Cardinals. The Nationals are +164 to cover, while the Cardinals are -200 to cover as a 1.5-run underdog on the runline.

Cardinals vs Nationals Over/Under

• A total of 7.5 runs has been set for the Cardinals-Nationals game on Sept. 18, with the over available at -120 and the under at -102.

Bet on St. Louis Cardinals vs. Washington Nationals on FanDuel today!

Cardinals vs Nationals Betting Trends

• The Cardinals have come away with 27 wins in the 51 contests they have been listed as the favorites in this season.
• St. Louis has a record of 22-20 when favored by -112 or more this year.
• The Cardinals and their opponents have gone over in 69 of their 149 games with a total set by sportsbooks this season.
• The Cardinals have an against the spread mark of 80-69-0 in 149 games with a line this season.
• The Nationals have won 42.6% of the games this season they were the underdog on the moneyline (49-66).
• When it has played as a moneyline underdog with odds of -104 or longer, Washington has a 47-64 record (winning 42.3% of its games).
• The Nationals have played in 149 games with an over/under set, and have combined with opponents to go over the total 78 times (78-65-6).
• The Nationals have put together an 81-68-0 record ATS this season (covering 54.4% of the time).

Cardinals Player Leaders

• Alec Burleson leads St. Louis in slugging percentage (.471) thanks to 61 extra-base hits. He has a .284 batting average and an on-base percentage of .350.
• Among all qualified hitters in baseball, he is 16th in batting average, 44th in on-base percentage, and 30th in slugging.
• Burleson hopes to build on a four-game hitting streak in this matchup. In his last five games he is batting .278 with two doubles, a home run, two walks and five RBIs.
• Jordan Walker leads St. Louis in total hits (160) this season while batting .278 with 61 extra-base hits. He's slugging .482 with an on-base percentage of .336.
• He is 24th in batting average, 61st in on-base percentage and 24th in slugging among qualifying hitters.
• Ivan Herrera has 138 hits this season and a team-best OBP of .355.
• JJ Wetherholt has 17 home runs, 48 RBI and a batting average of .240 this season.

Nationals Player Leaders

• C.J. Abrams has a .495 slugging percentage, which leads the Nationals. He's batting .264 with an on-base percentage of .339.
• Including all the qualifying players in the big leagues, he is 55th in batting average, 57th in on-base percentage and 17th in slugging percentage.
• Abrams hopes to build on a four-game hitting streak in this matchup. In his last five games he is batting .333 with four doubles and an RBI.
• James Wood's 127 hits and .391 on-base percentage both pace his team. He has a batting average of .265 while slugging .518.
• Including all qualifying players, he ranks 54th in batting average, fourth in on-base percentage and ninth in slugging percentage.
• Daylen Lile has 27 doubles, eight triples, 21 home runs and 39 walks while batting .251.
• Jacob Young is hitting .247 with 20 doubles, three triples, 10 home runs and 32 walks.

Cardinals vs Nationals Head to Head

• 4/8/2026: 6-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 4/7/2026: 7-6 STL (Favorite: Nationals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/6/2026: 9-6 WSH (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/10/2025: 8-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/9/2025: 8-2 WSH (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/11/2025: 6-1 STL (Favorite: Nationals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/10/2025: 4-2 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/9/2025: 10-0 STL (Favorite: Nationals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 7/28/2024: 4-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 7/27/2024: 14-3 WSH (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)

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