Twins vs Angels Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 18

Odds updated as of 9:11 p.m.

In MLB action on Friday, the Minnesota Twins face the Los Angeles Angels.

All the information you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Twins vs Angels Game Info

• Minnesota Twins (71-82) vs. Los Angeles Angels (59-94)
• Date: Friday, September 18, 2026
• Time: 9:38 p.m. ET
• Venue: Angel Stadium -- Anaheim, California
• Coverage: ABTV and Twins.TV

Twins vs Angels Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIN: (-118) | LAA: (+100)
• Spread: MIN: -1.5 (+146) | LAA: +1.5 (-178)
• Total: 8.5 -- Over: (+110) | Under: (-134)

Twins vs Angels Probable Starting Pitchers

Probable Pitchers: Connor Prielipp (Twins) - 5-7, 5.24 ERA vs Grayson Rodriguez (Angels) - 4-7, 6.10 ERA

The probable starters are Connor Prielipp (5-7) for the Twins and Grayson Rodriguez (4-7) for the Angels. Prielipp's team is 11-9-0 against the spread this season in his starts. Prielipp's team has been victorious in 75% of the games he's started as the moneyline favorite with a record of 3-1. The Angels have a 9-9-0 ATS record in Rodriguez's 18 starts with a set spread. The Angels have been the moneyline underdog in 17 of Rodriguez's starts this season, and they went 4-13 in those games.

Twins vs Angels Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (55.7%)

Twins vs Angels Moneyline

• Minnesota is the favorite, -118 on the moneyline, while Los Angeles is a +100 underdog despite being at home.

Twins vs Angels Spread

• The Twins are favored by 1.5 runs on the road against the Angels. The Twins are +146 to cover the spread, while the Angels are -178.

Twins vs Angels Over/Under

• A combined run total of 8.5 has been set for Twins-Angels on Sept. 18, with the over at +110 and the under at -134.

Bet on Minnesota Twins vs. Los Angeles Angels on FanDuel today!

Twins vs Angels Betting Trends

• The Twins have been victorious in 28, or 51.9%, of the 54 contests they have been chosen as favorites in this season.
• Minnesota has a record of 17-17 when favored by -118 or more this year.
• The Twins and their opponents have hit the over in 85 of their 149 games with a total set by oddsmakers this season.
• In 149 games with a line this season, the Twins have a mark of 79-70-0 against the spread.
• The Angels have a 44-80 record in games they were listed as the moneyline underdog (winning 35.5% of those games).
• Los Angeles has gone 39-70 when it has played as a moneyline underdog with odds of +100 or longer (35.8%).
• In the 152 games bookmakers have set an over/under for the Angels, they have combined with opponents to go over the total 63 times (63-86-3).
• The Angels have an 81-71-0 record ATS this season.

Twins Player Leaders

• Brooks Lee is hitting .248 with 23 doubles, three triples, 23 home runs and 36 walks. He has an on-base percentage of .298 and a slugging percentage of .427.
• Among all qualifying batters in baseball, he is 82nd in batting average, 120th in on-base percentage, and 66th in slugging.
• Lee hopes to build on a two-game hitting streak in this matchup. In his last five games he is batting .235 with two walks and two RBIs.
• Josh Bell has 28 doubles, a triple, 20 home runs and 48 walks. He's batting .252 and slugging .419 with an on-base percentage of .315.
• Among qualified hitters, his batting average ranks him 72nd, his on-base percentage 97th, and his slugging percentage 74th.
• Bell takes a two-game streak with at least one hit into this one. In his last five games he is hitting .190 with a home run, a walk and two RBIs.
• Kody Clemens leads Minnesota in total hits (120) this season, and 55 of those have gone for extra bases.
• Clemens brings a three-game hitting streak into this game. In his last five games he is batting .211 with a double, a triple, three walks and an RBI.
• Luke Keaschall has a slash line of .279/.370/.387 this season and a team-best OPS of .757.
• Keaschall takes a three-game hitting streak into this matchup. During his last five outings he is hitting .450 with three walks and an RBI.

Angels Player Leaders

• Zach Neto has put up a team-high slugging percentage (.440) and paces the Angels in hits (142). He's batting .241 and with an on-base percentage of .323.
• Including all qualified hitters in the big leagues, his batting average puts him 95th, his on-base percentage is 81st, and he is 56th in slugging.
• Mike Trout has a .379 OBP to lead his team. He has a batting average of .241 while slugging .423.
• Including all qualifying hitters, he ranks 95th in batting average, ninth in on-base percentage and 71st in slugging percentage.
• Vaughn Grissom is batting .238 with 22 doubles, 11 home runs and 28 walks.
• Wade Meckler is batting .294 with 14 doubles, three home runs and 30 walks.

Twins vs Angels Head to Head

• 9/17/2026: 5-4 LAA (Favorite: Angels, Spread: -1.5, Total: 7.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 7/12/2026: 4-2 MIN (Favorite: Twins, Spread: -1.5, Total: 9.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/11/2026: 5-3 MIN (Favorite: Twins, Spread: -1.5, Total: 9, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 7/10/2026: 4-3 LAA (Favorite: Twins, Spread: -1.5, Total: 9.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 9/10/2025: 4-3 LAA (Favorite: Angels, Spread: -1.5, Total: 9.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/9/2025: 12-2 LAA (Favorite: Twins, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/8/2025: 12-3 MIN (Favorite: Angels, Spread: -1.5, Total: 9.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 4/27/2025: 5-0 MIN (Favorite: Twins, Spread: -1.5, Total: 8, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 4/26/2025: 5-1 MIN (Favorite: Twins, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/25/2025: 11-4 MIN (Favorite: Twins, Spread: -1.5, Total: 8, Favorite Moneyline: -205, Underdog Moneyline: +172)

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