White Sox vs Royals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 22

Odds updated as of 2:11 a.m.

Tuesday's slate in the MLB includes a matchup between the Chicago White Sox and the Kansas City Royals.

All the information you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

White Sox vs Royals Game Info

• Chicago White Sox (80-76) vs. Kansas City Royals (67-89)
• Date: Tuesday, September 22, 2026
• Time: 7:40 p.m. ET
• Venue: Kauffman Stadium -- Kansas City, Missouri
• Coverage: Royals.TV and CHSN

White Sox vs Royals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHW: (-118) | KC: (+100)
• Spread: CHW: -1.5 (+146) | KC: +1.5 (-176)
• Total: 8.5 -- Over: (+108) | Under: (-132)

White Sox vs Royals Probable Starting Pitchers

Probable Pitchers: Anthony Kay (White Sox) - 9-9, 4.47 ERA vs Daniel Lynch (Royals) - 6-5, 3.29 ERA

The probable starters are Anthony Kay (9-9) for the White Sox and Daniel Lynch (6-5) for the Royals. Kay's team is 18-10-0 against the spread this season in his starts. Kay's team is 1-3 this season when he starts and they are the moneyline favorite. The Royals have a 3-4-0 ATS record in Lynch's seven starts with a set spread. The Royals are 3-2 in Lynch's five starts this season that they were the moneyline underdog.

White Sox vs Royals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Royals win (51.6%)

White Sox vs Royals Moneyline

• Kansas City is the underdog, +100 on the moneyline, while Chicago is a -118 favorite despite being on the road.

White Sox vs Royals Spread

• The White Sox are at the Royals and are favored by 1.5 runs (+146 to cover) on the runline. Kansas City is -176 to cover.

White Sox vs Royals Over/Under

• White Sox versus Royals, on Sept. 22, has an over/under of 8.5, with the over being +108 and the under -132.

Bet on Chicago White Sox vs. Kansas City Royals on FanDuel today!

White Sox vs Royals Betting Trends

• The White Sox have been favorites in 40 games this season and have come away with the win 22 times (55%) in those contests.
• This season Chicago has come away with a win 17 times in 30 chances when named as a favorite of at least -118 on the moneyline.
• The White Sox and their opponents have hit the over in 85 of their 153 games with a total set by oddsmakers this season.
• In 153 games with a line this season, the White Sox have a mark of 86-67-0 against the spread.
• The Royals have won 38.8% of the games this season they were the moneyline underdog (38-60).
• Kansas City has gone 31-50 when playing as a moneyline underdog with odds of +100 or longer (38.3%).
• The Royals have combined with opponents to go over the total 67 times this season for a 67-79-3 record against the over/under.
• The Royals have gone 75-74-0 against the spread this season.

White Sox Player Leaders

• Miguel Vargas leads Chicago in total hits (143) this season while batting .251 with 65 extra-base hits. He has an on-base percentage of .362 and a slugging percentage of .482.
• Among qualified hitters in MLB, he is 77th in batting average, 27th in on-base percentage, and 24th in slugging.
• Vargas hopes to build on a three-game hitting streak in this matchup. During his last five outings he is hitting .313 with a double, two home runs, six walks and four RBIs.
• Chase Meidroth has hit 15 homers this season while driving in 58 runs. He's batting .268 this season and slugging .401 with an on-base percentage of .343.
• Among qualifying hitters, he is 44th in batting average, 51st in on-base percentage and 90th in slugging percentage.
• Sam Antonacci has 124 hits this season and a team-best OBP of .363.
• Tristan Peters is batting .272 with a .344 OBP and 54 RBI for Chicago this season.

Royals Player Leaders

• Bobby Witt Jr. has a .359 on-base percentage and a .440 slugging percentage, both team-high numbers for the Royals. He's batting .279.
• Including all the qualified hitters in the majors, his batting average places him 26th, his on-base percentage is 31st, and he is 53rd in slugging.
• Witt enters this game on a three-game hitting streak. During his last five outings he is batting .263 with three walks.
• Carter Jensen is hitting .233 with 33 doubles, two triples, 25 home runs and 64 walks. He's slugging .454 with an on-base percentage of .319.
• His batting average is 109th among all qualified players, his on-base percentage is 90th, and he is 42nd in slugging.
• Jac Caglianone has 138 hits, a team-best for the Royals.
• Vinnie Pasquantino has 18 doubles, two triples, 14 home runs and 50 walks while hitting .244.

White Sox vs Royals Head to Head

• 6/28/2026: 5-4 KC (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/27/2026: 2-1 CHW (Favorite: White Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 6/26/2026: 22-1 CHW (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/14/2026: 6-2 CHW (Favorite: Royals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 5/13/2026: 6-5 CHW (Favorite: Royals, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/12/2026: 6-5 CHW (Favorite: Royals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 4/11/2026: 2-0 KC (Favorite: Royals, Spread: -1.5, Total: 9, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 4/10/2026: 2-0 KC (Favorite: Royals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 4/9/2026: 2-0 CHW (Favorite: Royals, Spread: -1.5, Total: 9, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 8/27/2025: 12-1 KC (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)

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