Tigers vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 22

Odds updated as of 6:11 p.m.

The MLB slate on Tuesday includes the Detroit Tigers taking on the Washington Nationals.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Tigers vs Nationals Game Info

• Detroit Tigers (74-83) vs. Washington Nationals (73-84)
• Date: Tuesday, September 22, 2026
• Time: 6:40 p.m. ET
• Venue: Comerica Park -- Detroit, Michigan
• Coverage: DSN and Nationals.TV

Tigers vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DET: (-152) | WSH: (+128)
• Spread: DET: -1.5 (+142) | WSH: +1.5 (-172)
• Total: 8.5 -- Over: (+104) | Under: (-128)

Tigers vs Nationals Probable Starting Pitchers

Probable Pitchers: Drew Anderson (Tigers) - 5-6, 3.62 ERA vs Riley Cornelio (Nationals) - 3-2, 4.22 ERA

The Tigers will give the nod to Drew Anderson (5-6) against the Nationals and Riley Cornelio (3-2). When Anderson starts, his team is 6-4-0 against the spread this season. Anderson's team has been victorious in 33.3% of the games he's started as the moneyline favorite with a record of 1-2. Cornelio has started two games with set spreads, and the Nationals went 1-1-0. The Nationals were named the moneyline underdog for one Cornelio start this season -- they lost.

Tigers vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Tigers win (57%)

Tigers vs Nationals Moneyline

• Detroit is a -152 favorite on the moneyline, while Washington is a +128 underdog on the road.

Tigers vs Nationals Spread

• The Nationals are at the Tigers, and are +1.5 on the runline. The Nationals are +142 to cover the spread, and the Tigers are -172.

Tigers vs Nationals Over/Under

• Tigers versus Nationals, on Sept. 22, has an over/under of 8.5, with the over being +104 and the under -128.

Bet on Detroit Tigers vs. Washington Nationals on FanDuel today!

Tigers vs Nationals Betting Trends

• The Tigers have been victorious in 43, or 55.1%, of the 78 contests they have been chosen as favorites in this season.
• This season Detroit has come away with a win 13 times in 20 chances when named as a favorite of at least -152 on the moneyline.
• The Tigers and their opponents have gone over in 67 of their 151 games with a total set by sportsbooks this season.
• The Tigers have posted a record of 78-73-0 against the spread this season.
• The Nationals have put together a 49-68 record in games they were the underdog on the moneyline (winning 41.9% of those games).
• Washington has a record of 19-43 in games it has played as a moneyline underdog with odds of +128 or longer (30.6%).
• The Nationals have combined with opponents to go over the total 81 times this season for an 81-66-6 record against the over/under.
• The Nationals have an 83-70-0 record ATS this season (covering 54.2% of the time).

Tigers Player Leaders

• Kevin McGonigle leads Detroit with an OBP of .376, plus a team-best slugging percentage of .424. He's batting .274 on the season.
• Among qualified hitters in MLB, he ranks 35th in batting average, 11th in on-base percentage, and 68th in slugging.
• Riley Greene leads Detroit with 141 hits. He is batting .284 this season and has 54 extra-base hits. He's also slugging .481 with an on-base percentage of .371.
• He ranks 17th in batting average, 13th in on-base percentage and 25th in slugging among qualified hitters.
• Dillon Dingler has 132 hits this season and has a slash line of .245/.304/.453.
• Dingler enters this matchup with four games in a row with at least one hit. During his last five outings he is batting .278 with two doubles, a walk and an RBI.
• Spencer Torkelson has been key for Detroit with 118 hits, an OBP of .325 plus a slugging percentage of .428.
• Torkelson has safely hit in two games in a row. In his last five games he is batting .333 with a double, a home run, three walks and two RBIs.

Nationals Player Leaders

• C.J. Abrams has accumulated a slugging percentage of .489, a team-high for the Nationals. He's batting .260 with an on-base percentage of .334.
• Including all the qualified players in the big leagues, his batting average ranks 63rd, his on-base percentage is 63rd, and he is 20th in slugging.
• James Wood's 131 hits and .389 on-base percentage are both team-highs. He has a batting average of .265 while slugging .511.
• Including all qualifying hitters, he is 51st in batting average, fourth in on-base percentage and 12th in slugging percentage.
• Daylen Lile has put up a team-high .437 slugging percentage.
• Jacob Young has 22 doubles, three triples, 10 home runs and 33 walks while batting .252.

Tigers vs Nationals Head to Head

• 9/21/2026: 9-2 DET (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/3/2025: 11-7 WSH (Favorite: Tigers, Spread: -1.5, Total: 9.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 7/2/2025: 9-4 WSH (Favorite: Nationals, Spread: -1.5, Total: 8, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 7/2/2025: 11-2 DET (Favorite: Tigers, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 6/13/2024: 7-2 DET (Favorite: Tigers, Spread: -1.5, Total: 9.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 6/12/2024: 7-5 WSH (Favorite: Tigers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 6/11/2024: 5-4 WSH (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/21/2023: 6-4 WSH (Favorite: Nationals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 5/20/2023: 5-2 WSH (Favorite: Nationals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 5/19/2023: 8-6 DET (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)

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