Pirates vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 22

Odds updated as of 6:11 p.m.

The MLB schedule on Tuesday includes the Pittsburgh Pirates taking on the St. Louis Cardinals.

We've got you covered, in terms of the vital info regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Pirates vs Cardinals Game Info

• Pittsburgh Pirates (79-77) vs. St. Louis Cardinals (76-80)
• Date: Tuesday, September 22, 2026
• Time: 6:40 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and Cardinals.TV

Pirates vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-172) | STL: (+144)
• Spread: PIT: -1.5 (+136) | STL: +1.5 (-164)
• Total: 7.5 -- Over: (+110) | Under: (-134)

Pirates vs Cardinals Probable Starting Pitchers

Probable Pitchers: Jared Jones (Pirates) - 4-6, 4.17 ERA vs Andre Pallante (Cardinals) - 12-7, 3.70 ERA

The probable starters are Jared Jones (4-6) for the Pirates and Andre Pallante (12-7) for the Cardinals. Jones' team is 9-10-0 against the spread in his starts this season. Jones' team is 3-4 this season when he starts and they are the moneyline favorite. The Cardinals have a 14-12-0 ATS record in Pallante's 26 starts that had a set spread. The Cardinals are 9-4 in Pallante's 13 starts this season that they were the moneyline underdog.

Pirates vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (59.3%)

Pirates vs Cardinals Moneyline

• St. Louis is the underdog, +144 on the moneyline, while Pittsburgh is a -172 favorite at home.

Pirates vs Cardinals Spread

• The Pirates are 1.5-run home favorites on the runline against the Cardinals. The Pirates are +136 to cover, and the Cardinals are -164.

Pirates vs Cardinals Over/Under

• The over/under for the Pirates versus Cardinals game on Sept. 22 has been set at 7.5, with +110 odds on the over and -134 odds on the under.

Bet on Pittsburgh Pirates vs. St. Louis Cardinals on FanDuel today!

Pirates vs Cardinals Betting Trends

• The Pirates have come away with 46 wins in the 79 contests they have been listed as the favorites in this season.
• This year Pittsburgh has won nine of 16 games when listed as at least -172 on the moneyline.
• The Pirates and their opponents have gone over the total this season in 81 of their 154 opportunities.
• The Pirates are 77-77-0 against the spread in their 154 games with a line set by sportsbooks this season.
• The Cardinals have won 45 of the 97 games they were the underdog on the moneyline this season (46.4%).
• St. Louis has an 8-10 record (winning 44.4% of its games) when playing as a moneyline underdog of +144 or longer.
• In the 152 games bookmakers have set an over/under for the Cardinals, they have combined with opponents to go over the total 71 times (71-74-7).
• The Cardinals have put together an 81-71-0 record against the spread this season.

Pirates Player Leaders

• Bryan Reynolds leads Pittsburgh with an OBP of .365 this season while batting .262 with 85 walks and 101 runs scored. He has a slugging percentage of .423.
• Among qualified batters, he is 58th in batting average, his on-base percentage ranks 20th, and he is 71st in slugging.
• Brandon Lowe leads Pittsburgh in total hits (148) this season while batting .262 with 63 extra-base hits. He's slugging .492 with an on-base percentage of .332.
• His batting average ranks 58th among qualified players, his on-base percentage 67th, and his slugging percentage 17th.
• Lowe enters this game looking to extend his eight-game hit streak. In his last 10 games he is batting .324 with a double, four home runs, five walks and 10 RBIs.
• Nick Gonzales has a team-best OPS of .754, fueled by a slash line of .302/.365/.389 this season.
• Ryan O'Hearn has 18 home runs, 73 RBI and a batting average of .264 this season.

Cardinals Player Leaders

• Alec Burleson has a .466 slugging percentage, which paces the Cardinals. He's batting .282 with an on-base percentage of .347.
• Including all the qualifying hitters in the majors, his batting average is 18th, his on-base percentage ranks 47th, and he is 34th in slugging.
• Jordan Walker's 161 hits pace his team. He has a batting average of .274 while slugging .474 with an on-base percentage of .332.
• Including all qualifying hitters, his batting average puts him 35th, his on-base percentage ranks 67th, and he is 29th in slugging.
• Ivan Herrera has racked up a team-best .358 on-base percentage.
• JJ Wetherholt is batting .242 with 14 doubles, 17 home runs and 63 walks.

Pirates vs Cardinals Head to Head

• 8/30/2026: 5-4 PIT (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +110)
• 8/29/2026: 6-2 PIT (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +110)
• 8/28/2026: 4-1 STL (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: +104)
• 5/21/2026: 6-2 PIT (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/20/2026: 7-0 PIT (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/19/2026: 9-6 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/30/2026: 10-5 STL (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -245, Underdog Moneyline: +200)
• 4/29/2026: 5-4 STL (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 4/28/2026: 11-7 STL (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 4/27/2026: 4-2 STL (Favorite: Pirates, Spread: -1.5, Total: 8, Favorite Moneyline: -122, Underdog Moneyline: +104)

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