Twins vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for May 6

Odds updated as of 7:11 p.m.

The Tuesday schedule in MLB includes a matchup between the Minnesota Twins and the Baltimore Orioles.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Twins vs Orioles Game Info

• Minnesota Twins (15-20) vs. Baltimore Orioles (13-20)
• Date: Tuesday, May 6, 2025
• Time: 7:40 p.m. ET
• Venue: Target Field -- Minneapolis, Minnesota
• Coverage: MNNT and MASN

Twins vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIN: (-172) | BAL: (+144)
• Spread: MIN: -1.5 (+122) | BAL: +1.5 (-146)
• Total: 9 -- Over: (-110) | Under: (-110)

Twins vs Orioles Probable Starting Pitchers

Probable Pitchers: Pablo Lopez (Twins) - 2-2, 2.25 ERA vs Cade Povich (Orioles) - 1-2, 5.16 ERA

The Twins will call on Pablo Lopez (2-2) versus the Orioles and Cade Povich (1-2). Lopez and his team are 3-2-0 ATS this season when he starts. Lopez's team has won 50% of his starts when they are favored on the moneyline (2-2). The Orioles have a 1-5-0 record against the spread in Povich's starts. The Orioles were the underdog on the moneyline for two Povich starts this season -- they split the games.

Twins vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (57.3%)

Twins vs Orioles Moneyline

• Minnesota is the favorite, -172 on the moneyline, while Baltimore is a +144 underdog on the road.

Twins vs Orioles Spread

• The Orioles are +1.5 on the run line against the Twins. The Orioles are -146 to cover, and the Twins are +122.

Twins vs Orioles Over/Under

• The Twins-Orioles game on May 6 has been given an over/under of 9 runs. The over is set at -110 and the under at -110.

Bet on Minnesota Twins vs. Baltimore Orioles on FanDuel today!

Twins vs Orioles Betting Trends

• The Twins have come away with 11 wins in the 23 contests they have been listed as the favorites in this season.
• Minnesota has a record of 5-2 when favored by -172 or more this year.
• Contests with the Twins have gone over the total set by sportsbooks in 12 of 34 chances this season.
• In 34 games with a line this season, the Twins have a mark of 16-18-0 against the spread.
• The Orioles have won 42.9% of the games this season they were the underdog on the moneyline (6-8).
• Baltimore has played as a moneyline underdog of +144 or longer in just one game this season, which it lost.
• The Orioles have had an over/under set by bookmakers 33 times, and have combined with opponents to go over the total in 16 of those games (16-15-2).
• The Orioles are 11-22-0 ATS this season.

Twins Player Leaders

• Byron Buxton leads Minnesota with 33 hits and a team-best slugging percentage of .488. He's batting .260 with an on-base percentage of .294.
• Among the qualified batters in the majors, his batting average ranks 64th, his on-base percentage ranks 118th, and he is 34th in slugging.
• Buxton hopes to build on a five-game hitting streak in this matchup. In his last five games he is batting .364 with a home run, a walk and an RBI.
• Ty France has 32 hits this season and a team-best OBP of .326. He's batting .254 and slugging .381.
• Among qualified hitters, he ranks 75th in batting average, 74th in on-base percentage and 104th in slugging percentage.
• Trevor Larnach has 28 hits this season and has a slash line of .230/.321/.344.
• Larnach has recorded at least one base hit in three games in a row. During his last five outings he is batting .263 with three walks and two RBIs.
• Ryan Jeffers is batting .278 with a .363 OBP and 13 RBI for Minnesota this season.
• Jeffers has safely hit in three games in a row. In his last five games he is hitting .375 with a double, a home run, a walk and three RBIs.

Orioles Player Leaders

• Cedric Mullins has accumulated an on-base percentage of .379, a slugging percentage of .491, and has 28 hits, all club-bests for the Orioles (while batting .255).
• Including all the qualifying players in the big leagues, he ranks 72nd in batting average, 30th in on-base percentage and 30th in slugging percentage.
• Ryan O'Hearn is hitting .306 with four doubles, seven home runs and nine walks. He's slugging .600 with an on-base percentage of .379.
• Adley Rutschman has four doubles, four home runs and 17 walks while hitting .216.
• Jackson Holliday is batting .273 with a double, a triple, four home runs and seven walks.

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