Cubs vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for May 6

Odds updated as of 7:11 p.m.

Tuesday's slate in the MLB includes a matchup between the Chicago Cubs and the San Francisco Giants.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info about this game.

Cubs vs Giants Game Info

• Chicago Cubs (22-14) vs. San Francisco Giants (22-14)
• Date: Tuesday, May 6, 2025
• Time: 7:40 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MARQ and NBCS-BA

Cubs vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-148) | SF: (+126)
• Spread: CHC: -1.5 (+134) | SF: +1.5 (-162)
• Total: 8 -- Over: (-112) | Under: (-108)

Cubs vs Giants Probable Starting Pitchers

Probable Pitchers: Colin Rea (Cubs) - 2-0, 1.46 ERA vs Justin Verlander (Giants) - 0-2, 4.62 ERA

The probable pitchers are Colin Rea (2-0) for the Cubs and Justin Verlander (0-2) for the Giants. Rea and his team have covered in each of the three games he's started with a spread this season. This will be Rea's first game as the moneyline favorite this season. The Giants are 1-6-0 against the spread when Verlander starts. The Giants were named the moneyline underdog for three Verlander starts this season -- they lost all of the games.

Cubs vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (61.4%)

Cubs vs Giants Moneyline

• The Cubs vs Giants moneyline has Chicago as a -148 favorite, while San Francisco is a +126 underdog on the road.

Cubs vs Giants Spread

• The Cubs are favored by 1.5 runs at home against the Giants. The Cubs are +134 to cover the spread, while the Giants are -162.

Cubs vs Giants Over/Under

• An over/under of 8 has been set for Cubs-Giants on May 6, with the over being -112 and the under -108.

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Cubs vs Giants Betting Trends

• The Cubs have been favorites in 17 games this season and have come away with the win 13 times (76.5%) in those contests.
• This season Chicago has been victorious five times in seven chances when named as a favorite of at least -148 on the moneyline.
• The Cubs and their opponents have hit the over in 22 of their 34 games with a total set by oddsmakers this season.
• The Cubs are 19-15-0 against the spread in their 34 games that had a posted line this season.
• The Giants have been the underdog on the moneyline 13 total times this season. They've gone 6-7 in those games.
• San Francisco has a record of 1-3 when it has played as a moneyline underdog with odds of +126 or longer (25%).
• In the 36 games oddsmakers have set an over/under for the Giants, they have combined with opponents to go over the total 21 times (21-14-1).
• The Giants are 17-19-0 ATS this season.

Cubs Player Leaders

• Kyle Tucker leads Chicago in OBP (.393) and total hits (40) this season. He's batting .284 batting average while slugging .560.
• Among all qualified hitters, he is 36th in batting average, his on-base percentage ranks 15th, and he is 10th in slugging.
• Pete Crow-Armstrong is hitting .271 with 10 doubles, a triple, nine home runs and six walks, while slugging .550 with an on-base percentage of .306.
• He is 52nd in batting average, 102nd in on-base percentage and 16th in slugging among qualifying hitters.
• Crow-Armstrong has picked up a hit in four straight games. During his last five outings he is hitting .250 with three home runs and five RBIs.
• Ian Happ has hit three homers with a team-high .407 SLG this season.
• Happ has picked up a hit in seven games in a row. During his last 10 games he is hitting .342 with four doubles, a home run, six walks and six RBIs.
• Carson Kelly is batting .361 with a .500 OBP and 23 RBI for Chicago this season.
• Kelly enters this matchup on a six-game hitting streak. In his last 10 outings he is hitting .324 with a double, four home runs, six walks and 10 RBIs.

Giants Player Leaders

• Jung Hoo Lee has a .485 slugging percentage, which paces the Giants. He's batting .303 with an on-base percentage of .359.
• Including all qualifying hitters in the majors, he ranks 17th in batting average, 42nd in on-base percentage and 35th in slugging percentage.
• Matt Chapman has four doubles, seven home runs and 27 walks while hitting .210. He's slugging .411 with an on-base percentage of .351.
• His batting average ranks 132nd among all qualified players, his on-base percentage ranks 53rd, and he is 79th in slugging.
• Michael Yastrzemski has racked up an on-base percentage of .387 and has 30 hits, both team-high numbers for the Giants.
• Wilmer Flores has two doubles, seven home runs and seven walks while hitting .240.

Cubs vs Giants Head to Head

• 5/5/2025: 9-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 6/27/2024: 5-3 CHC (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 6/26/2024: 4-3 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/25/2024: 5-1 SF (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 6/24/2024: 5-4 SF (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/19/2024: 6-5 CHC (Favorite: Cubs, Spread: -1.5, Total: 11, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 6/18/2024: 5-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/17/2024: 7-6 SF (Favorite: Cubs, Spread: -1.5, Total: 10.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/6/2023: 8-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 11, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 9/5/2023: 11-8 CHC (Favorite: Cubs, Spread: -1.5, Total: 10.5, Favorite Moneyline: -126, Underdog Moneyline: +108)

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