Royals vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for May 6

Odds updated as of 7:11 p.m.

The MLB's Tuesday schedule includes the Kansas City Royals taking on the Chicago White Sox.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info about this game.

Royals vs White Sox Game Info

• Kansas City Royals (20-16) vs. Chicago White Sox (10-25)
• Date: Tuesday, May 6, 2025
• Time: 7:40 p.m. ET
• Venue: Kauffman Stadium -- Kansas City, Missouri
• Coverage: FDSKC and CHSN

Royals vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: KC: (-255) | CHW: (+210)
• Spread: KC: -1.5 (-114) | CHW: +1.5 (-105)
• Total: 8.5 -- Over: (-112) | Under: (-108)

Royals vs White Sox Probable Starting Pitchers

Probable Pitchers: Seth Lugo (Royals) - 3-3, 3.07 ERA vs Sean Burke (White Sox) - 2-4, 4.91 ERA

The Royals will give the nod to Seth Lugo (3-3, 3.07 ERA), who is eyeing win No. 4 on the season, and the White Sox will turn to Sean Burke (2-4, 4.91 ERA). Lugo's team is 4-3-0 against the spread in his starts this season. Lugo's team won his only start as a favorite this season. The White Sox have a 4-2-0 record against the spread in Burke's starts. The White Sox have a 3-3 record in Burke's six starts this season when they were the underdog on the moneyline.

Royals vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Royals win (65.9%)

Royals vs White Sox Moneyline

• Looking at the moneyline for White Sox-Royals, Chicago is the underdog at +210, and Kansas City is -255 playing at home.

Royals vs White Sox Spread

• The Royals are 1.5-run home favorites on the runline against the White Sox. The Royals are -114 to cover, and the White Sox are -105.

Royals vs White Sox Over/Under

• A total of 8.5 runs has been set for the Royals-White Sox contest on May 6, with the over available at -112 and the under at -108.

Bet on Kansas City Royals vs. Chicago White Sox on FanDuel today!

Royals vs White Sox Betting Trends

• The Royals have been favorites in 14 games this season and have come away with the win 10 times (71.4%) in those contests.
• Kansas City has been listed as a favorite of -255 or more on two occasions this season and won both games.
• Contests with the Royals have gone over the total set by oddsmakers in 12 of 36 chances this season.
• The Royals have an against the spread record of 19-17-0 in 36 games with a line this season.
• The White Sox have been the underdog on the moneyline 35 total times this season. They've finished 10-25 in those games.
• Chicago has a 1-3 record (winning only 25% of its games) when playing as a moneyline underdog of +210 or longer.
• The White Sox have played in 35 games with a set over/under, and have combined with their opponents to go over the total 17 times (17-16-2).
• The White Sox have an 18-17-0 record against the spread this season (covering 51.4% of the time).

Royals Player Leaders

• Bobby Witt Jr. leads Kansas City with 43 hits and a team-best slugging percentage of .504. He's batting .314 with an on-base percentage of .389.
• Among qualifying batters in MLB, he is 13th in batting average, 19th in on-base percentage, and 24th in slugging.
• Witt has recorded a base hit in two games in a row. During his last five outings he is hitting .263 with two doubles, two home runs, three walks and six RBIs.
• Maikel Garcia leads Kansas City in OBP (.390) this season, fueled by 39 hits. He's batting .322 while slugging .496.
• Among all qualified hitters, he is seventh in batting average, 18th in on-base percentage and 27th in slugging percentage.
• Garcia heads into this matchup looking to extend his three-game hit streak. During his last five outings he is hitting .556 with a double, two home runs, four walks and five RBIs.
• Vinnie Pasquantino has 26 hits this season and has a slash line of .191/.245/.375.
• Jonathan India has been key for Kansas City with 28 hits, an OBP of .336 plus a slugging percentage of .303.
• India takes a three-game hitting streak into this matchup. In his last five games he is batting .300 with a double, a home run, three walks and an RBI.

White Sox Player Leaders

• Luis Robert has 22 hits, a team-best for the White Sox. He's batting .188 and slugging .342 with an on-base percentage of .304.
• He is 150th in batting average, 104th in on-base percentage and 129th in slugging percentage among all qualified batters in the majors.
• Miguel Vargas leads his team with a .319 OBP. He has a batting average of .223 while slugging .322.
• He is 118th in batting average, 84th in on-base percentage and 139th in slugging percentage in the majors.
• Andrew Benintendi is hitting .224 with five home runs and eight walks.
• Brooks Baldwin is hitting .240 with five doubles, three home runs and five walks.

Royals vs White Sox Head to Head

• 5/5/2025: 3-0 KC (Favorite: Royals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 7/31/2024: 10-3 KC (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 7/30/2024: 4-3 KC (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -186, Underdog Moneyline: +156)
• 7/29/2024: 8-5 KC (Favorite: Royals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 7/21/2024: 4-1 KC (Favorite: Royals, Spread: -1.5, Total: 8, Favorite Moneyline: -230, Underdog Moneyline: +190)
• 7/20/2024: 6-1 KC (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 7/19/2024: 7-1 KC (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 4/17/2024: 2-1 CHW (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 4/17/2024: 4-2 KC (Favorite: Royals, Spread: -1.5, Total: 9, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 4/15/2024: 2-0 KC (Favorite: Royals, Spread: -1.5, Total: 8, Favorite Moneyline: -172, Underdog Moneyline: +144)

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