Royals vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for May 6

Odds updated as of 4:15 a.m.

The Kansas City Royals versus the Chicago White Sox is on the MLB schedule for Tuesday.

All the info you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Royals vs White Sox Game Info

• Kansas City Royals (20-16) vs. Chicago White Sox (10-25)
• Date: Tuesday, May 6, 2025
• Time: 7:40 p.m. ET
• Venue: Kauffman Stadium -- Kansas City, Missouri
• Coverage: FDSKC and CHSN

Royals vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: KC: (-220) | CHW: (+184)
• Spread: KC: -1.5 (-105) | CHW: +1.5 (-114)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Royals vs White Sox Probable Starting Pitchers

Probable Pitchers: Seth Lugo (Royals) - 3-3, 3.07 ERA vs Sean Burke (White Sox) - 2-4, 4.91 ERA

The Royals will give the ball to Seth Lugo (3-3, 3.07 ERA), who is eyeing win No. 4 on the season, and the White Sox will turn to Sean Burke (2-4, 4.91 ERA). Lugo's team is 4-3-0 against the spread in his starts this season. Lugo's team won his only start as a favorite this season. The White Sox are 4-2-0 against the spread when Burke starts. The White Sox have a 3-3 record in Burke's six starts this season when they were the underdog on the moneyline.

Royals vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Royals win (65.5%)

Royals vs White Sox Moneyline

• Chicago is a +184 underdog on the moneyline, while Kansas City is a -220 favorite at home.

Royals vs White Sox Spread

• The White Sox are at +1.5 on the runline against the Royals. The White Sox are -114 to cover the spread, and the Royals are -105.

Royals vs White Sox Over/Under

• A total of 8.5 runs has been set for the Royals-White Sox contest on May 6, with the over available at -105 and the under at -115.

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Royals vs White Sox Betting Trends

• The Royals have been chosen as favorites in 14 games this year and have walked away with the win 10 times (71.4%) in those games.
• Kansas City has not lost in three games this year when favored by -220 or better on the moneyline.
• The Royals' games have gone over the total in 12 of their 36 opportunities.
• The Royals have posted a record of 19-17-0 against the spread this season.
• The White Sox have put together a 10-25 record in games they were listed as the moneyline underdog (winning 28.6% of those games).
• Chicago is 4-12 (winning just 25% of its games) when it has played as a moneyline underdog of +184 or longer.
• The White Sox have played in 35 games with a set over/under, and have combined with opponents to go over the total 17 times (17-16-2).
• The White Sox are 18-17-0 against the spread this season.

Royals Player Leaders

• Bobby Witt Jr. has 43 hits to go with a slugging percentage of .504, both of which lead Kansas City hitters this season. He has a .314 batting average and an on-base percentage of .389.
• He is 13th in batting average, 19th in on-base percentage, and 24th in slugging among all qualifying hitters in MLB.
• Witt has hit safely in two straight games. In his last five games he is batting .263 with two doubles, two home runs, three walks and six RBI.
• Maikel Garcia has 39 hits this season and a team-best OBP of .390. He's batting .322 and slugging .496.
• Among qualifying batters, he ranks seventh in batting average, 18th in on-base percentage and 27th in slugging percentage.
• Garcia heads into this matchup looking to extend his three-game hit streak. In his last five games he is batting .556 with a double, two home runs, four walks and five RBI.
• Vinnie Pasquantino is batting .191 with a .375 slugging percentage and 22 RBI this year.
• Jonathan India is batting .230 with a .336 OBP and six RBI for Kansas City this season.
• India enters this game on a three-game hitting streak. During his last five outings he is hitting .300 with a double, a home run, three walks and an RBI.

White Sox Player Leaders

• Luis Robert is leading the White Sox with 22 hits. He's batting .188 and slugging .342 with an on-base percentage of .304.
• Including all qualified players, he is 150th in batting average, while his on-base percentage ranks 104th and he is 129th in slugging.
• Miguel Vargas' .319 on-base percentage leads his team. He has a batting average of .223 while slugging .322.
• His batting average ranks 118th among all qualified players, his on-base percentage ranks 84th, and he is 139th in slugging.
• Andrew Benintendi is hitting .224 with five home runs and eight walks.
• Brooks Baldwin is batting .240 with five doubles, three home runs and five walks.

Royals vs White Sox Head to Head

• 5/5/2025: 3-0 KC (Favorite: Royals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 7/31/2024: 10-3 KC (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 7/30/2024: 4-3 KC (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -186, Underdog Moneyline: +156)
• 7/29/2024: 8-5 KC (Favorite: Royals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 7/21/2024: 4-1 KC (Favorite: Royals, Spread: -1.5, Total: 8, Favorite Moneyline: -230, Underdog Moneyline: +190)
• 7/20/2024: 6-1 KC (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 7/19/2024: 7-1 KC (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 4/17/2024: 2-1 CHW (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 4/17/2024: 4-2 KC (Favorite: Royals, Spread: -1.5, Total: 9, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 4/15/2024: 2-0 KC (Favorite: Royals, Spread: -1.5, Total: 8, Favorite Moneyline: -172, Underdog Moneyline: +144)

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