Reds vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for May 21

Odds updated as of 12:12 p.m.

The MLB's Wednesday slate includes the Cincinnati Reds taking on the Pittsburgh Pirates.

We've got you covered, in terms of the vital info about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Reds vs Pirates Game Info

• Cincinnati Reds (25-25) vs. Pittsburgh Pirates (16-33)
• Date: Wednesday, May 21, 2025
• Time: 12:35 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and FDSOH

Reds vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CIN: (-126) | PIT: (+108)
• Spread: CIN: -1.5 (+130) | PIT: +1.5 (-156)
• Total: 8 -- Over: (-110) | Under: (-110)

Reds vs Pirates Probable Starting Pitchers

Probable Pitchers: Brady Singer (Reds) - 5-2, 5.01 ERA vs Andrew Heaney (Pirates) - 2-3, 3.02 ERA

The Reds will give the nod to Brady Singer (5-2) against the Pirates and Andrew Heaney (2-3). Singer and his team are 6-3-0 ATS this season when he starts. Singer's team has won 50% of his starts when they are favored on the moneyline (2-2). The Pirates have a 3-5-0 ATS record in Heaney's eight starts that had a set spread. The Pirates have been the underdog on the moneyline in six of Heaney's starts this season, and they went 2-4 in those games.

Reds vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (55.3%)

Reds vs Pirates Moneyline

• Looking at the moneyline for Pirates-Reds, Pittsburgh is the underdog at +108, and Cincinnati is -126 playing on the road.

Reds vs Pirates Spread

• The Reds are at the Pirates and are favored by 1.5 runs (+130 to cover) on the runline. Pittsburgh is -156 to cover.

Reds vs Pirates Over/Under

• A combined run total of 8 has been set for Reds-Pirates on May 21, with the over at -110 and the under at -110.

Bet on Cincinnati Reds vs. Pittsburgh Pirates on FanDuel today!

Reds vs Pirates Betting Trends

• The Reds have been victorious in 12, or 57.1%, of the 21 contests they have been chosen as favorites in this season.
• This year Cincinnati has won seven of 13 games when listed as at least -126 on the moneyline.
• The Reds' games have gone over the total in 18 of their 48 opportunities.
• The Reds have an against the spread record of 26-22-0 in 48 games with a line this season.
• The Pirates have won 34.4% of the games this season they were the moneyline underdog (11-21).
• When it has played as a moneyline underdog with odds of +108 or longer, Pittsburgh has a 9-18 record (winning only 33.3% of its games).
• The Pirates have played in 47 games with a set over/under, and have combined with opponents to go over the total 17 times (17-27-3).
• The Pirates have covered 40.4% of their games this season, going 19-28-0 against the spread.

Reds Player Leaders

• Elly De La Cruz has eight doubles, eight home runs and 19 walks while hitting .246. He has an on-base percentage of .318 and a slugging percentage of .410.
• Among qualified hitters in the majors, his batting average ranks 97th, his on-base percentage ranks 99th, and he is 88th in slugging.
• TJ Friedl has hit three homers this season while driving in 18 runs. He's batting .280 this season and slugging .400 with an on-base percentage of .366.
• He is 48th in batting average, 39th in on-base percentage and 97th in slugging among qualified hitters.
• Friedl brings a two-game streak with at least one hit into this contest. In his last five games he is hitting .333 with two doubles, a triple, three walks and an RBI.
• Gavin Lux has 45 hits and an OBP of .379, both of which lead the Reds this season.
• Austin Hays has six home runs, 19 RBI and a batting average of .319 this season.

Pirates Player Leaders

• Oneil Cruz has 31 hits, a team-best for the Pirates. He's batting .220 and slugging .426 with an on-base percentage of .353.
• Including all qualified players, he ranks 136th in batting average, while his on-base percentage ranks 54th and he is 75th in slugging.
• Andrew McCutchen has seven doubles, three home runs and 20 walks while hitting .243. He's slugging .357 with an on-base percentage of .344.
• Including all qualifying hitters, his batting average puts him 100th, his on-base percentage ranks 64th, and he is 133rd in slugging.
• Bryan Reynolds is batting .206 with five doubles, six home runs and 17 walks.
• Isiah Kiner-Falefa is batting .282 with three doubles, a triple, a home run and eight walks.

Reds vs Pirates Head to Head

• 5/20/2025: 1-0 PIT (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 5/19/2025: 7-1 CIN (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/13/2025: 4-0 CIN (Favorite: Reds, Spread: -1.5, Total: 7.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 4/12/2025: 5-2 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/11/2025: 5-3 CIN (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 9/22/2024: 2-0 PIT (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/21/2024: 7-1 CIN (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/20/2024: 8-3 CIN (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/25/2024: 4-3 PIT (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 8/24/2024: 10-2 CIN (Favorite: Pirates, Spread: -1.5, Total: 9, Favorite Moneyline: -108, Underdog Moneyline: -108)

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