Reds vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for May 18

Odds updated as of 1:11 p.m.

In MLB action on Sunday, the Cincinnati Reds take on the Cleveland Guardians.

We've got you covered, in terms of the most important info about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Reds vs Guardians Game Info

• Cincinnati Reds (23-24) vs. Cleveland Guardians (25-20)
• Date: Sunday, May 18, 2025
• Time: 1:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: MLB Network, FDSOH, and CLEG

Reds vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CIN: (-136) | CLE: (+116)
• Spread: CIN: -1.5 (+146) | CLE: +1.5 (-178)
• Total: 9 -- Over: (-105) | Under: (-115)

Reds vs Guardians Probable Starting Pitchers

Probable Pitchers: Andrew Abbott (Reds) - 2-0, 2.10 ERA vs Luis Ortiz (Guardians) - 2-4, 4.78 ERA

The probable pitchers are Andrew Abbott (2-0) for the Reds and Luis Ortiz (2-4) for the Guardians. Abbott's team is 4-1-0 against the spread this season in his starts. Abbott's team is 2-0 this season when he starts and they're favored on the moneyline. The Guardians have a 3-5-0 ATS record in Ortiz's eight starts that had a set spread. The Guardians are 1-3 in Ortiz's four starts this season that they were the underdog on the moneyline.

Reds vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (56.1%)

Reds vs Guardians Moneyline

• Cleveland is the underdog, +116 on the moneyline, while Cincinnati is a -136 favorite at home.

Reds vs Guardians Spread

• The Reds are hosting the Guardians and are favored by 1.5 runs on the spread. The Reds are +146 to cover the runline, with the Guardians being -178.

Reds vs Guardians Over/Under

• A total of 9 runs has been set for the Reds-Guardians game on May 18, with the over available at -105 and the under at -115.

Bet on Cincinnati Reds vs. Cleveland Guardians on FanDuel today!

Reds vs Guardians Betting Trends

• The Reds have been chosen as favorites in 18 games this year and have walked away with the win 10 times (55.6%) in those games.
• This season Cincinnati has been victorious five times in nine chances when named as a favorite of at least -136 on the moneyline.
• Contests with the Reds have gone over the total set by bookmakers in 18 of 45 chances this season.
• The Reds are 24-21-0 against the spread in their 45 games with a line set by sportsbooks this season.
• The Guardians have won 12 of the 25 games they were the underdog on the moneyline this season (48%).
• Cleveland is 4-6 (winning 40% of its games) when it has played as a moneyline underdog of +116 or longer.
• The Guardians have played in 44 games with an over/under set, and have combined with their opponents to go over the total 22 times (22-20-2).
• The Guardians have a 20-24-0 record ATS this season (covering 45.5% of the time).

Reds Player Leaders

• Elly De La Cruz leads Cincinnati with 46 hits and a team-best slugging percentage of .415. He's batting .251 with an on-base percentage of .324.
• Among qualified hitters in MLB, his batting average ranks 91st, his on-base percentage ranks 90th, and he is 86th in slugging.
• TJ Friedl is batting .268 with seven doubles, a triple, three home runs and 21 walks. He's slugging .378 with an on-base percentage of .354.
• Among qualifying batters, he ranks 58th in batting average, 52nd in on-base percentage and 111th in slugging percentage.
• Gavin Lux leads Cincinnati in OBP (.386) this season, fueled by 43 hits.
• Lux has recorded at least one base hit in three straight games. During his last five outings he is batting .353 with two doubles, a walk and an RBI.
• Austin Hays has been key for Cincinnati with 25 hits, an OBP of .368 plus a slugging percentage of .608.
• Hays heads into this game on a four-game hitting streak. In his last five games he is batting .278 with two doubles, a home run, a walk and four RBIs.

Guardians Player Leaders

• Jose Ramirez has 46 hits, a team-high for the Guardians. He's batting .293 and slugging .516 with an on-base percentage of .358.
• Including all the qualifying players in the big leagues, his batting average places him 30th, his on-base percentage ranks 45th, and he is 24th in slugging.
• Ramirez hopes to build on an 11-game hitting streak in this matchup. During his last 10 games he is batting .389 with three doubles, four home runs, five walks and seven RBIs.
• Steven Kwan paces his team with a .378 on-base percentage, and has a club-best .438 slugging percentage. He has a batting average of .318.
• Including all qualified hitters, his batting average places him eighth, his on-base percentage ranks 25th, and he is 65th in slugging.
• Kyle Manzardo is batting .223 with four doubles, two triples, 10 home runs and 18 walks.
• Carlos Santana is hitting .215 with three doubles, four home runs and 22 walks.

Reds vs Guardians Head to Head

• 5/17/2025: 4-1 CIN (Favorite: Guardians, Spread: -1.5, Total: 10, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/16/2025: 5-4 CIN (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/25/2024: 5-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/24/2024: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 6/12/2024: 4-2 CIN (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/11/2024: 5-3 CLE (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/27/2023: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 9/26/2023: 11-7 CIN (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/16/2023: 7-2 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 8/15/2023: 3-0 CLE (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -120, Underdog Moneyline: +102)

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