Pirates vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for April 7

Odds updated as of 2:12 a.m.

The MLB's Tuesday schedule includes the Pittsburgh Pirates facing the San Diego Padres.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Pirates vs Padres Game Info

• Pittsburgh Pirates (6-4) vs. San Diego Padres (5-5)
• Date: Tuesday, April 7, 2026
• Time: 6:40 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and Padres.TV

Pirates vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-148) | SD: (+126)
• Spread: PIT: -1.5 (+152) | SD: +1.5 (-184)
• Total: 6.5 -- Over: (-112) | Under: (-108)

Pirates vs Padres Probable Starting Pitchers

Probable Pitchers: Paul Skenes (Pirates) - 1-1, 9.53 ERA vs Nick Pivetta (Padres) - 1-1, 6.75 ERA

The Pirates will give the nod to Paul Skenes (1-1) against the Padres and Nick Pivetta (1-1). Skenes has a record of 1-1-0 ATS in two starts with a spread this season. Skenes' team won his only start as a favorite this season. Pivetta has started two games with set spreads, and the Padres went 1-1-0. The Padres were the moneyline underdog for one Pivetta start this season -- they lost.

Pirates vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (51.3%)

Pirates vs Padres Moneyline

• San Diego is a +126 underdog on the moneyline, while Pittsburgh is a -148 favorite at home.

Pirates vs Padres Spread

• The Pirates are favored by 1.5 runs at home versus the Padres. The Pirates are +152 to cover the spread, while the Padres are -184.

Pirates vs Padres Over/Under

• An over/under of 6.5 has been set for Pirates-Padres on April 7, with the over being -112 and the under -108.

Bet on Pittsburgh Pirates vs. San Diego Padres on FanDuel today!

Pirates vs Padres Betting Trends

• The Pirates have come away with four wins in the five contests they have been listed as the favorites in this season.
• Pittsburgh has played as a favorite of -148 or more just one time this year and came away with a win in that game.
• The Pirates and their opponents have gone over the total this season in five of their 10 opportunities.
• The Pirates have posted a record of 6-4-0 against the spread this season.
• The Padres have won three of the six games they were listed as the moneyline underdog this season (50%).
• San Diego has played as a moneyline underdog of +126 or longer in only one game this season, which it won.
• The Padres have played in 10 games with an over/under set, and have combined with opponents to go over the total three times (3-6-1).
• The Padres have put together a 6-4-0 record against the spread this season.

Pirates Player Leaders

• Ryan O'Hearn leads Pittsburgh in OBP (.463), slugging percentage (.697) and total hits (12) this season. He has a .364 batting average.
• Among all qualifying hitters in baseball, his batting average ranks 11th, his on-base percentage ranks eighth, and he is seventh in slugging.
• O'Hearn has recorded a base hit in three games in a row. During his last five outings he is hitting .294 with two doubles, two home runs, four walks and eight RBIs.
• Oneil Cruz leads Pittsburgh in slugging percentage (.615) thanks to four extra-base hits. He's batting .308 with an on-base percentage of .357.
• Among qualified hitters, his batting average places him 35th, his on-base percentage 65th, and his slugging percentage 17th.
• Cruz heads into this game looking to extend his six-game hit streak. During his last 10 games he is hitting .308 with four home runs, two walks and 10 RBIs.
• Brandon Lowe has collected nine base hits, an OBP of .400 and a slugging percentage of .606 this season.
• Lowe has picked up a hit in two games in a row. During his last five outings he is hitting .158 with a double and three walks.
• Bryan Reynolds has two home runs, five RBI and a batting average of .231 this season.

Padres Player Leaders

• Jackson Merrill has a slugging percentage of .472 and has nine hits, both team-best numbers for the Padres. He's batting .250 and with an on-base percentage of .308.
• Including all the qualifying hitters in MLB, he is 81st in batting average, 114th in on-base percentage and 58th in slugging percentage.
• Ramon Laureano leads his team with nine hits and has a club-best .472 slugging percentage. He has a batting average of .250 with an on-base percentage of .289.
• Including all qualified players, he is 81st in batting average, 133rd in on-base percentage and 58th in slugging percentage.
• Manny Machado a has .415 on-base percentage to lead the Padres.
• Fernando Tatis Jr. has three doubles and six walks while hitting .189.

Pirates vs Padres Head to Head

• 4/6/2026: 5-0 SD (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/1/2025: 6-4 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 5/31/2025: 5-0 PIT (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -240, Underdog Moneyline: +198)
• 5/30/2025: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 5/4/2025: 4-0 SD (Favorite: Pirates, Spread: -1.5, Total: 9, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 5/2/2025: 9-4 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 8/14/2024: 8-2 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 8/13/2024: 3-0 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -250, Underdog Moneyline: +205)
• 8/12/2024: 2-1 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 8/8/2024: 7-6 SD (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!