Pirates vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for April 7

Odds updated as of 6:11 p.m.

In MLB action on Tuesday, the Pittsburgh Pirates take on the San Diego Padres.

We've got you covered, in terms of the vital information about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Pirates vs Padres Game Info

• Pittsburgh Pirates (6-4) vs. San Diego Padres (5-5)
• Date: Tuesday, April 7, 2026
• Time: 6:40 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and Padres.TV

Pirates vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-148) | SD: (+126)
• Spread: PIT: -1.5 (+152) | SD: +1.5 (-184)
• Total: 6 -- Over: (-115) | Under: (-105)

Pirates vs Padres Probable Starting Pitchers

Probable Pitchers: Paul Skenes (Pirates) - 1-1, 9.53 ERA vs Nick Pivetta (Padres) - 1-1, 6.75 ERA

The Pirates will give the nod to Paul Skenes (1-1, 9.53 ERA), who is eyeing win No. 2 on the season, and the Padres will turn to Nick Pivetta (1-1, 6.75 ERA). Skenes has a record of 1-1-0 ATS in two starts with a spread this season. Skenes' team won his only start as a favorite this season. Pivetta has started two games with set spreads, and the Padres went 1-1-0. The Padres were named the moneyline underdog for one Pivetta start this season -- they lost.

Pirates vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (50.5%)

Pirates vs Padres Moneyline

• San Diego is the underdog, +126 on the moneyline, while Pittsburgh is a -148 favorite at home.

Pirates vs Padres Spread

• The Pirates are favored by 1.5 runs at home versus the Padres. The Pirates are +152 to cover the spread, while the Padres are -184.

Pirates vs Padres Over/Under

• An over/under of 6 has been set for Pirates-Padres on April 7, with the over being -115 and the under -105.

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Pirates vs Padres Betting Trends

• The Pirates have won in four of the five contests they have been named as odds-on favorites in this year.
• Pittsburgh has played as a favorite of -148 or more just one time this year and came away with a win in that game.
• Contests with the Pirates have gone over the total set by oddsmakers in five of 10 chances this season.
• The Pirates have posted a record of 6-4-0 against the spread this season.
• The Padres have won 50% of the games this season they were the underdog on the moneyline (3-3).
• San Diego has played as a moneyline underdog of +126 or longer in only one game this season, which it won.
• The Padres have played in 10 games with an over/under set, and have combined with opponents to go over the total three times (3-6-1).
• The Padres have put together a 6-4-0 record against the spread this season.

Pirates Player Leaders

• Ryan O'Hearn leads Pittsburgh in OBP (.463), slugging percentage (.697) and total hits (12) this season. He has a .364 batting average.
• Among all qualifying hitters in baseball, his batting average ranks 11th, his on-base percentage ranks eighth, and he is seventh in slugging.
• O'Hearn has hit safely in three games in a row. In his last five games he is batting .294 with two doubles, two home runs, four walks and eight RBIs.
• Oneil Cruz has hit four homers this season while driving in 10 runs. He's batting .308 this season and slugging .615 with an on-base percentage of .357.
• He ranks 35th in batting average, 63rd in on-base percentage and 17th in slugging in the major leagues.
• Cruz heads into this game looking to extend his six-game hit streak. In his last 10 outings he is hitting .308 with four home runs, two walks and 10 RBIs.
• Brandon Lowe has nine hits this season and has a slash line of .273/.400/.606.
• Lowe has picked up a hit in two straight games. In his last five games he is hitting .158 with a double and three walks.
• Bryan Reynolds has been key for Pittsburgh with nine hits, an OBP of .326 plus a slugging percentage of .410.

Padres Player Leaders

• Jackson Merrill has accumulated nine hits with a .472 slugging percentage, both team-best figures for the Padres. He's batting .250 and with an on-base percentage of .308.
• Including all the qualified players in the big leagues, his batting average ranks 79th, his on-base percentage is 113th, and he is 58th in slugging.
• Ramon Laureano has collected nine hits while slugging .472. Both lead his team. He has a batting average of .250 with an on-base percentage of .289.
• He ranks 79th in batting average, 133rd in on-base percentage and 58th in slugging percentage in the majors.
• Manny Machado has put up a team-high .415 on-base percentage.
• Fernando Tatis Jr. is batting .189 with three doubles and six walks.

Pirates vs Padres Head to Head

• 4/6/2026: 5-0 SD (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/1/2025: 6-4 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 5/31/2025: 5-0 PIT (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -240, Underdog Moneyline: +198)
• 5/30/2025: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 5/4/2025: 4-0 SD (Favorite: Pirates, Spread: -1.5, Total: 9, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 5/2/2025: 9-4 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 8/14/2024: 8-2 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 8/13/2024: 3-0 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -250, Underdog Moneyline: +205)
• 8/12/2024: 2-1 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 8/8/2024: 7-6 SD (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)

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