Pirates vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 23

Odds updated as of 1:11 a.m.

The Wednesday schedule in MLB includes a matchup between the Pittsburgh Pirates and the St. Louis Cardinals.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Pirates vs Cardinals Game Info

• Pittsburgh Pirates (80-77) vs. St. Louis Cardinals (76-81)
• Date: Wednesday, September 23, 2026
• Time: 6:40 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and Cardinals.TV

Pirates vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-116) | STL: (-102)
• Spread: PIT: +1.5 (-205) | STL: -1.5 (+168)
• Total: 7.5 -- Over: (-118) | Under: (-104)

Pirates vs Cardinals Probable Starting Pitchers

Probable Pitchers: Lake Bachar (Pirates) - 1-4, 3.56 ERA vs Matthew Liberatore (Cardinals) - 5-14, 5.36 ERA

The Pirates will give the nod to Lake Bachar (1-4, 3.56 ERA), who is eyeing win No. 2 on the season, and the Cardinals will counter with Matthew Liberatore (5-14, 5.36 ERA). Bachar's team is 8-3-0 against the spread in his starts this season. Bachar's team has won each of the three games he's started as the moneyline favorite. The Cardinals are 14-15-0 ATS in Liberatore's 29 starts with a set spread. The Cardinals have been the underdog on the moneyline in 18 of Liberatore's starts this season, and they went 8-10 in those matchups.

Pirates vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (57.4%)

Pirates vs Cardinals Moneyline

• Looking at the moneyline for Cardinals-Pirates, St. Louis is the underdog at -102, and Pittsburgh is -116 playing at home.

Pirates vs Cardinals Spread

• The Cardinals are 1.5-run favorites against the spread for this matchup with the Pirates. The Cardinals are +168 to cover, while the Pirates are -205 to cover as a 1.5-run underdog on the runline.

Pirates vs Cardinals Over/Under

• The over/under for Pirates-Cardinals on Sept. 23 is 7.5. The over is -118, and the under is -104.

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Pirates vs Cardinals Betting Trends

• The Pirates have won in 47, or 58.8%, of the 80 contests they have been named as odds-on favorites in this year.
• Pittsburgh has a record of 42-31 in contests when oddsmakers favor them by -116 or more on the moneyline.
• The Pirates and their opponents have gone over in 81 of their 155 games with a total set by sportsbooks this season.
• The Pirates have an against the spread record of 78-77-0 in 155 games with a line this season.
• The Cardinals have won 45 of the 98 games they were listed as the moneyline underdog this season (45.9%).
• St. Louis has a 38-45 record (winning 45.8% of its games) when playing as a moneyline underdog of -102 or longer.
• The Cardinals have played in 153 games with an over/under set, and have combined with their opponents to go over the total 71 times (71-75-7).
• The Cardinals have gone 81-72-0 ATS this season.

Pirates Player Leaders

• Bryan Reynolds leads Pittsburgh in OBP (.365) this season, fueled by 153 hits. He has a .262 batting average and a slugging percentage of .425.
• Among qualified hitters in MLB, he is 58th in batting average, 21st in on-base percentage, and 68th in slugging.
• Reynolds hopes to build on a two-game hitting streak in this matchup. In his last five games he is hitting .263 with four doubles and a walk.
• Brandon Lowe leads Pittsburgh with 148 hits. He is batting .260 this season and has 63 extra-base hits. He's also slugging .489 with an on-base percentage of .330.
• He ranks 64th in batting average, 71st in on-base percentage and 18th in slugging in the major leagues.
• Nick Gonzales has a team-best OPS of .754, fueled by a slash line of .302/.365/.389 this season.
• Ryan O'Hearn has been key for Pittsburgh with 103 hits, an OBP of .330 plus a slugging percentage of .441.
• O'Hearn takes a two-game hitting streak into this matchup. During his last five outings he is hitting .222 with two walks and two RBIs.

Cardinals Player Leaders

• Alec Burleson has a .463 slugging percentage, which paces the Cardinals. He's batting .280 with an on-base percentage of .345.
• Including all the qualifying hitters in MLB, he ranks 23rd in batting average, 49th in on-base percentage and 36th in slugging percentage.
• Jordan Walker has racked up 161 hits to lead his team. He has a batting average of .273 while slugging .471 with an on-base percentage of .331.
• His batting average ranks 36th among all qualified players, his on-base percentage is 68th, and he is 29th in slugging.
• Ivan Herrera a has .356 on-base percentage to lead the Cardinals.
• JJ Wetherholt is batting .240 with 14 doubles, 17 home runs and 63 walks.

Pirates vs Cardinals Head to Head

• 9/22/2026: 2-0 PIT (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 8/30/2026: 5-4 PIT (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +110)
• 8/29/2026: 6-2 PIT (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +110)
• 8/28/2026: 4-1 STL (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: +104)
• 5/21/2026: 6-2 PIT (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/20/2026: 7-0 PIT (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/19/2026: 9-6 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/30/2026: 10-5 STL (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -245, Underdog Moneyline: +200)
• 4/29/2026: 5-4 STL (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 4/28/2026: 11-7 STL (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)

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