Pirates vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 23

Odds updated as of 6:11 p.m.

The Wednesday schedule in MLB includes a matchup between the Pittsburgh Pirates and the St. Louis Cardinals.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info about this matchup.

Pirates vs Cardinals Game Info

• Pittsburgh Pirates (80-77) vs. St. Louis Cardinals (76-81)
• Date: Wednesday, September 23, 2026
• Time: 6:40 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and Cardinals.TV

Pirates vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-134) | STL: (+116)
• Spread: PIT: -1.5 (+158) | STL: +1.5 (-192)
• Total: 7.5 -- Over: (+104) | Under: (-128)

Pirates vs Cardinals Probable Starting Pitchers

Probable Pitchers: Lake Bachar (Pirates) - 1-4, 3.56 ERA vs Matthew Liberatore (Cardinals) - 5-14, 5.36 ERA

The probable pitchers are Lake Bachar (1-4) for the Pirates and Matthew Liberatore (5-14) for the Cardinals. When Bachar starts, his team is 8-3-0 against the spread this season. Bachar and his team have won each of the three games he's started as the moneyline favorite. The Cardinals have a 14-15-0 ATS record in Liberatore's 29 starts with a set spread. The Cardinals have been the underdog on the moneyline in 18 of Liberatore's starts this season, and they went 8-10 in those matchups.

Pirates vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (62.4%)

Pirates vs Cardinals Moneyline

• Pittsburgh is a -134 favorite on the moneyline, while St. Louis is a +116 underdog on the road.

Pirates vs Cardinals Spread

• The Cardinals are +1.5 on the spread (-192 to cover), and Pittsburgh is +158 to cover the runline.

Pirates vs Cardinals Over/Under

• The Pirates-Cardinals contest on Sept. 23 has been given an over/under of 7.5 runs. The over is set at +104 and the under at -128.

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Pirates vs Cardinals Betting Trends

• The Pirates have won in 47, or 58.8%, of the 80 contests they have been named as odds-on favorites in this year.
• This year Pittsburgh has won 23 of 43 games when listed as at least -134 on the moneyline.
• Contests with the Pirates have gone over the total set by sportsbooks in 81 of 155 chances this season.
• The Pirates have an against the spread mark of 78-77-0 in 155 games with a line this season.
• The Cardinals have been the underdog on the moneyline 98 total times this season. They've finished 45-53 in those games.
• When it has played as a moneyline underdog with odds of +116 or longer, St. Louis has a 22-24 record (winning 47.8% of its games).
• The Cardinals have played in 153 games with a set over/under, and have combined with opponents to go over the total 71 times (71-75-7).
• The Cardinals have covered 52.9% of their games this season, going 81-72-0 against the spread.

Pirates Player Leaders

• Bryan Reynolds has 153 hits this season and a team-best OBP of .365. He has a .262 batting average and a slugging percentage of .425.
• Among all qualifying batters in the majors, he ranks 57th in batting average, 21st in on-base percentage, and 68th in slugging.
• Reynolds will look for his third straight game with a hit in this contest. In his last five games he is hitting .263 with four doubles and a walk.
• Brandon Lowe leads Pittsburgh in total hits (148) this season while batting .260 with 63 extra-base hits. He's slugging .489 with an on-base percentage of .330.
• Among all qualified hitters, he is 65th in batting average, 71st in on-base percentage and 18th in slugging percentage.
• Nick Gonzales is slashing .302/.365/.389 this season and leads the Pirates with an OPS of .754.
• Ryan O'Hearn is batting .264 with a .330 OBP and 74 RBI for Pittsburgh this season.
• O'Hearn has safely hit in two games in a row. During his last five outings he is hitting .222 with two walks and two RBIs.

Cardinals Player Leaders

• Alec Burleson has racked up a team-best .463 slugging percentage. He's batting .280 with an on-base percentage of .345.
• Including all qualified hitters, he ranks 23rd in batting average, while his on-base percentage is 49th and he is 36th in slugging.
• Jordan Walker has racked up 161 hits to lead his team. He has a batting average of .273 while slugging .471 with an on-base percentage of .331.
• He is 36th in batting average, 68th in on-base percentage and 29th in slugging percentage in the big leagues.
• Ivan Herrera a has .356 on-base percentage to lead the Cardinals.
• JJ Wetherholt is hitting .240 with 14 doubles, 17 home runs and 63 walks.

Pirates vs Cardinals Head to Head

• 9/22/2026: 2-0 PIT (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 8/30/2026: 5-4 PIT (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +110)
• 8/29/2026: 6-2 PIT (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +110)
• 8/28/2026: 4-1 STL (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: +104)
• 5/21/2026: 6-2 PIT (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/20/2026: 7-0 PIT (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/19/2026: 9-6 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/30/2026: 10-5 STL (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -245, Underdog Moneyline: +200)
• 4/29/2026: 5-4 STL (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 4/28/2026: 11-7 STL (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)

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