Red Sox vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 23

Odds updated as of 7:11 p.m.

The MLB's Wednesday schedule includes the Boston Red Sox taking on the Cleveland Guardians.

All the info you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Red Sox vs Guardians Game Info

• Boston Red Sox (84-73) vs. Cleveland Guardians (82-75)
• Date: Wednesday, September 23, 2026
• Time: 7:10 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: ESPN

Red Sox vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-134) | CLE: (+114)
• Spread: BOS: -1.5 (+176) | CLE: +1.5 (-210)
• Total: 6.5 -- Over: (-122) | Under: (+100)

Red Sox vs Guardians Probable Starting Pitchers

Probable Pitchers: Sonny Gray (Red Sox) - 17-5, 2.82 ERA vs Foster Griffin (Guardians) - 15-5, 3.67 ERA

The Red Sox will look to Sonny Gray (17-5) versus the Guardians and Foster Griffin (15-5). Gray and his team have a record of 17-10-0 against the spread when he starts. When Gray starts a game and his team is the favorite on the moneyline, they have a record of 16-8. The Guardians have gone 17-11-0 ATS in Griffin's 28 starts that had a set spread. The Guardians are 12-5 in Griffin's 17 starts this season that they were the underdog on the moneyline.

Red Sox vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Red Sox win (59.6%)

Red Sox vs Guardians Moneyline

• Boston is the favorite, -134 on the moneyline, while Cleveland is a +114 underdog on the road.

Red Sox vs Guardians Spread

• The Guardians are at the Red Sox, and are +1.5 on the runline. The Guardians are +176 to cover the spread, and the Red Sox are -210.

Red Sox vs Guardians Over/Under

• A combined run total of 6.5 has been set for Red Sox-Guardians on Sept. 23, with the over at -122 and the under at +100.

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Red Sox vs Guardians Betting Trends

• The Red Sox have come away with 58 wins in the 107 contests they have been listed as the favorites in this season.
• Boston has a record of 31-29 in contests when oddsmakers favor them by -134 or more on the moneyline.
• The Red Sox and their opponents have gone over in 68 of their 154 games with a total set by sportsbooks this season.
• The Red Sox are 73-81-0 against the spread in their 154 games with a line set by sportsbooks this season.
• The Guardians are 29-27 in games they were the underdog on the moneyline (winning 51.8% of those games).
• Cleveland has a record of 16-12 in games it has played as a moneyline underdog with odds of +114 or longer (57.1%).
• The Guardians have had an over/under set by bookmakers 148 times, and have combined with opponents to go over the total in 73 of those games (73-75-0).
• The Guardians have a 70-78-0 record ATS this season (covering 47.3% of the time).

Red Sox Player Leaders

• Wilyer Abreu is batting .251 with 37 doubles, four triples, 24 home runs and 70 walks. He has an on-base percentage of .331 and a slugging percentage of .453.
• Among qualifying hitters in MLB, his batting average ranks 77th, his on-base percentage ranks 68th, and he is 44th in slugging.
• Caleb Durbin has 25 doubles, a triple, 13 home runs and 50 walks. He's batting .254 and slugging .387 with an on-base percentage of .338.
• Among qualifying hitters, he is 73rd in batting average, 57th in on-base percentage and 103rd in slugging percentage.
• Willson Contreras leads his team in OBP (.387) and total hits (123) this season.
• Contreras has recorded at least one base hit in two straight games. In his last five games he is hitting .267 with a home run, two walks and two RBIs.
• Jarren Duran is batting .204 with a .263 OBP and 69 RBI for Boston this season.

Guardians Player Leaders

• Chase DeLauter leads the Guardians with 140 hits. He's batting .292 and slugging .459 with an on-base percentage of .367.
• Including all the qualified hitters in the big leagues, he ranks 10th in batting average, 18th in on-base percentage and 37th in slugging percentage.
• DeLauter heads into this game on a four-game hitting streak. During his last five outings he is hitting .333 with a double, a home run, three walks and three RBIs.
• Steven Kwan paces his team with a .378 on-base percentage, and has a club-best .345 slugging percentage. He has a batting average of .280.
• Including all qualifying hitters, his batting average puts him 23rd, his on-base percentage is 11th, and he is 129th in slugging.
• Jose Ramirez is hitting .236 with 27 doubles, 12 home runs and 58 walks.
• Brayan Rocchio is hitting .250 with 24 doubles, two triples, 13 home runs and 37 walks.

Red Sox vs Guardians Head to Head

• 9/22/2026: 3-2 CLE (Favorite: Red Sox, Spread: -1.5, Total: 6.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 5/31/2026: 9-4 BOS (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/30/2026: 9-1 BOS (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/29/2026: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/3/2025: 8-1 CLE (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 9/2/2025: 11-7 BOS (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -270, Underdog Moneyline: +220)
• 9/1/2025: 6-4 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 4/27/2025: 13-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/26/2025: 7-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/26/2025: 5-4 CLE (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)

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