Pirates vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for May 6

Odds updated as of 4:16 a.m.

The MLB's Tuesday schedule includes the Pittsburgh Pirates facing the St. Louis Cardinals.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Pirates vs Cardinals Game Info

• Pittsburgh Pirates (12-24) vs. St. Louis Cardinals (17-19)
• Date: Tuesday, May 6, 2025
• Time: 7:45 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: FDSMW and SportsNet PT

Pirates vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-124) | STL: (+106)
• Spread: PIT: -1.5 (+146) | STL: +1.5 (-176)
• Total: 7 -- Over: (-118) | Under: (-104)

Pirates vs Cardinals Probable Starting Pitchers

Probable Pitchers: Paul Skenes (Pirates) - 3-3, 2.74 ERA vs Matthew Liberatore (Cardinals) - 2-3, 3.44 ERA

The Pirates will give the nod to Paul Skenes (3-3) against the Cardinals and Matthew Liberatore (2-3). Skenes' team is 3-4-0 against the spread in his starts this season. When Skenes starts a game and his team is the favorite on the moneyline, they have a record of 2-4. The Cardinals have a 1-5-0 ATS record in Liberatore's six starts with a set spread. The Cardinals were the underdog on the moneyline for two Liberatore starts this season -- they split the games.

Pirates vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (58.1%)

Pirates vs Cardinals Moneyline

• Looking at the moneyline for Cardinals-Pirates, St. Louis is the underdog at +106, and Pittsburgh is -124 playing on the road.

Pirates vs Cardinals Spread

• The Cardinals are +1.5 on the spread (-176 to cover), and Pittsburgh is +146 to cover the runline.

Pirates vs Cardinals Over/Under

• The over/under for the Pirates versus Cardinals contest on May 6 has been set at 7, with -118 odds on the over and -104 odds on the under.

Bet on Pittsburgh Pirates vs. St. Louis Cardinals on FanDuel today!

Pirates vs Cardinals Betting Trends

• The Pirates have won in five, or 41.7%, of the 12 contests they have been named as odds-on favorites in this year.
• This year Pittsburgh has won three of eight games when listed as at least -124 on the moneyline.
• The Pirates' games have gone over the total in 17 of their 35 opportunities.
• The Pirates have posted a record of 12-23-0 against the spread this season.
• The Cardinals have won 12 of the 25 games they were listed as the moneyline underdog this season (48%).
• In games it has played as a moneyline underdog with odds of +106 or longer, St. Louis has a record of 5-8 (38.5%).
• The Cardinals have played in 36 games with a set over/under, and have combined with opponents to go over the total 21 times (21-13-2).
• The Cardinals have put together a 17-19-0 record against the spread this season (covering 47.2% of the time).

Pirates Player Leaders

• Oneil Cruz leads Pittsburgh in OBP (.385) and total hits (29) this season. He's batting .252 batting average while slugging .504.
• He is 80th in batting average, 22nd in on-base percentage, and 24th in slugging among all qualified hitters in the majors.
• Bryan Reynolds leads Pittsburgh in slugging percentage (.371) thanks to 10 extra-base hits. He's batting .231 with an on-base percentage of .296.
• He is 106th in batting average, 115th in on-base percentage and 113th in slugging in MLB.
• Andrew McCutchen has 25 hits this season and has a slash line of .253/.345/.404.
• Enmanuel Valdez has two home runs, 12 RBI and a batting average of .221 this season.

Cardinals Player Leaders

• Lars Nootbaar has seven doubles, five home runs and 27 walks while hitting .237. He's slugging .400 with an on-base percentage of .368.
• Including all qualifying hitters, he is 99th in batting average, while his on-base percentage is 37th and he is 87th in slugging.
• Brendan Donovan leads his team with 44 hits and a .393 on-base percentage, with a team-high .481 slugging percentage. He has a batting average of .336.
• Including all qualified hitters, he is fifth in batting average, 15th in on-base percentage and 37th in slugging percentage.
• Nolan Arenado is hitting .256 with nine doubles, three home runs and 16 walks.
• Victor Scott II is hitting .284 with six doubles, a triple, two home runs and 12 walks.

Pirates vs Cardinals Head to Head

• 5/5/2025: 6-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 4/9/2025: 2-1 PIT (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/8/2025: 5-3 STL (Favorite: Pirates, Spread: -1.5, Total: 6.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 4/7/2025: 8-4 PIT (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/19/2024: 3-2 PIT (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/18/2024: 10-5 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 9/17/2024: 3-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 9/16/2024: 4-0 STL (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/24/2024: 5-0 PIT (Favorite: Pirates, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/23/2024: 2-1 STL (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -178, Underdog Moneyline: +150)

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