Pirates vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for May 6

Odds updated as of 7:11 p.m.

The Pittsburgh Pirates are among the MLB squads busy on Tuesday, up against the St. Louis Cardinals.

All the info you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Pirates vs Cardinals Game Info

• Pittsburgh Pirates (12-24) vs. St. Louis Cardinals (17-19)
• Date: Tuesday, May 6, 2025
• Time: 7:45 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: FDSMW and SportsNet PT

Pirates vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-118) | STL: (-100)
• Spread: PIT: -1.5 (+142) | STL: +1.5 (-176)
• Total: 7 -- Over: (-115) | Under: (-105)

Pirates vs Cardinals Probable Starting Pitchers

Probable Pitchers: Paul Skenes (Pirates) - 3-3, 2.74 ERA vs Matthew Liberatore (Cardinals) - 2-3, 3.44 ERA

This contest's pitching matchup is set, as the Pirates will send Paul Skenes (3-3) to the mound, while Matthew Liberatore (2-3) will get the nod for the Cardinals. Skenes and his team are 3-4-0 ATS this season when he starts. Skenes' team has been victorious in 33.3% of the games he's started as the moneyline favorite with a record of 2-4. When Liberatore starts, the Cardinals are 1-5-0 against the spread. The Cardinals were named the moneyline underdog for two Liberatore starts this season -- they split the games.

Pirates vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (57.6%)

Pirates vs Cardinals Moneyline

• Pittsburgh is the favorite, -118 on the moneyline, while St. Louis is a -100 underdog despite being at home.

Pirates vs Cardinals Spread

• The Cardinals are at +1.5 on the runline against the Pirates. The Cardinals are -176 to cover the spread, and the Pirates are +142.

Pirates vs Cardinals Over/Under

• An over/under of 7 has been set for Pirates-Cardinals on May 6, with the over being -115 and the under -105.

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Pirates vs Cardinals Betting Trends

• The Pirates have been victorious in five, or 41.7%, of the 12 contests they have been chosen as favorites in this season.
• Pittsburgh has a record of 3-7 when favored by -118 or more this year.
• The Pirates and their opponents have hit the over in 17 of their 35 games with a total set by oddsmakers this season.
• The Pirates have an against the spread mark of 12-23-0 in 35 games with a line this season.
• The Cardinals have won 12 of the 25 games they were listed as the moneyline underdog this season (48%).
• St. Louis has gone 6-11 in games it has played as a moneyline underdog with odds of -100 or longer (35.3%).
• In the 36 games oddsmakers have set an over/under for the Cardinals, they have combined with opponents to go over the total 21 times (21-13-2).
• The Cardinals have collected a 17-19-0 record ATS this season (covering 47.2% of the time).

Pirates Player Leaders

• Oneil Cruz has 29 hits and an OBP of .385, both of which are best among Pittsburgh hitters this season. He has a .252 batting average and a slugging percentage of .504.
• Among all qualified hitters, he ranks 80th in batting average, his on-base percentage ranks 22nd, and he is 24th in slugging.
• Bryan Reynolds has hit five homers this season while driving in 19 runs. He's batting .231 this season and slugging .371 with an on-base percentage of .296.
• Among qualifying hitters, his batting average ranks him 106th, his on-base percentage 115th, and his slugging percentage 113th.
• Andrew McCutchen has collected 25 base hits, an OBP of .345 and a slugging percentage of .404 this season.
• Enmanuel Valdez has two home runs, 12 RBI and a batting average of .221 this season.

Cardinals Player Leaders

• Lars Nootbaar is batting .237 with seven doubles, five home runs and 27 walks. He's slugging .400 with an on-base percentage of .368.
• Including all the qualified hitters in the majors, his batting average is 99th, his on-base percentage is 37th, and he is 87th in slugging.
• Brendan Donovan leads his team with 44 hits and a .393 OBP, with a team-leading .481 slugging percentage. He has a batting average of .336.
• Including all qualified players, he ranks fifth in batting average, 15th in on-base percentage and 37th in slugging percentage.
• Nolan Arenado is hitting .256 with nine doubles, three home runs and 16 walks.
• Victor Scott II has six doubles, a triple, two home runs and 12 walks while hitting .284.

Pirates vs Cardinals Head to Head

• 5/5/2025: 6-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 4/9/2025: 2-1 PIT (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/8/2025: 5-3 STL (Favorite: Pirates, Spread: -1.5, Total: 6.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 4/7/2025: 8-4 PIT (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/19/2024: 3-2 PIT (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/18/2024: 10-5 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 9/17/2024: 3-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 9/16/2024: 4-0 STL (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/24/2024: 5-0 PIT (Favorite: Pirates, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/23/2024: 2-1 STL (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -178, Underdog Moneyline: +150)

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