Pirates vs Brewers Prediction, Odds, Moneyline, Spread & Over/Under for May 23

Odds updated as of 2:11 p.m.

The MLB's Friday schedule includes the Pittsburgh Pirates taking on the Milwaukee Brewers.

We've got you covered, in terms of the most important info about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Pirates vs Brewers Game Info

• Pittsburgh Pirates (17-34) vs. Milwaukee Brewers (25-26)
• Date: Friday, May 23, 2025
• Time: 6:40 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and FDSWI

Pirates vs Brewers Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-124) | MIL: (+106)
• Spread: PIT: -1.5 (+180) | MIL: +1.5 (-220)
• Total: 6.5 -- Over: (-122) | Under: (-100)

Pirates vs Brewers Probable Starting Pitchers

Probable Pitchers: Paul Skenes (Pirates) - 3-5, 2.44 ERA vs Freddy Peralta (Brewers) - 5-3, 2.59 ERA

This contest's pitching matchup is set, as the Pirates will send Paul Skenes (3-5) to the mound, while Freddy Peralta (5-3) will take the ball for the Brewers. Skenes and his team are 4-6-0 ATS this season when he starts. Skenes' team has been victorious in 28.6% of the games he's started as the moneyline favorite with a record of 2-5. The Brewers are 6-4-0 ATS in Peralta's 10 starts that had a set spread. The Brewers were named the moneyline underdog for three Peralta starts this season -- they lost every game.

Pirates vs Brewers Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (55.9%)

Pirates vs Brewers Moneyline

• Milwaukee is the underdog, +106 on the moneyline, while Pittsburgh is a -124 favorite at home.

Pirates vs Brewers Spread

• The Brewers are at +1.5 on the runline against the Pirates. The Brewers are -220 to cover the spread, and the Pirates are +180.

Pirates vs Brewers Over/Under

• A combined run total of 6.5 has been set for Pirates-Brewers on May 23, with the over at -122 and the under at -100.

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Pirates vs Brewers Betting Trends

• The Pirates have come away with five wins in the 13 contests they have been listed as the favorites in this season.
• This season Pittsburgh has come away with a win three times in eight chances when named as a favorite of at least -124 on the moneyline.
• The Pirates and their opponents have gone over in 18 of their 49 games with a total set by sportsbooks this season.
• The Pirates are 20-29-0 against the spread in their 49 games that had a posted line this season.
• The Brewers have a 5-18 record in games they were the underdog on the moneyline (winning 21.7% of those games).
• Milwaukee has gone 2-12 when it has played as a moneyline underdog with odds of +106 or longer (14.3%).
• The Brewers have played in 50 games with an over/under set, and have combined with opponents to go over the total 20 times (20-29-1).
• The Brewers have a 27-23-0 record against the spread this season (covering 54% of the time).

Pirates Player Leaders

• Oneil Cruz leads Pittsburgh in total hits (33) this season while batting .223 with 14 extra-base hits. He has an on-base percentage of .357 and a slugging percentage of .426.
• He is 131st in batting average, 47th in on-base percentage, and 74th in slugging among qualified hitters in the majors.
• Cruz hopes to build on a two-game hitting streak in this matchup. In his last five games he is hitting .118 with a double, four walks and an RBI.
• Andrew McCutchen is hitting .246 with seven doubles, three home runs and 23 walks, while slugging .359 with an on-base percentage of .357.
• He ranks 94th in batting average, 47th in on-base percentage and 131st in slugging among qualifying hitters.
• McCutchen enters this game looking to extend his two-game hit streak. During his last five outings he is hitting .188 with four walks.
• Bryan Reynolds is batting .210 with a .338 slugging percentage and 25 RBI this year.
• Isiah Kiner-Falefa has been key for Pittsburgh with 37 hits, an OBP of .338 plus a slugging percentage of .359.
• Kiner-Falefa brings a five-game hitting streak into this game. During his last five outings he is batting .333 with two doubles and a walk.

Brewers Player Leaders

• William Contreras has six doubles, four home runs and 31 walks while batting .255. He's slugging .364 with an on-base percentage of .371.
• He is 82nd in batting average, 32nd in on-base percentage and 126th in slugging percentage among all qualified hitters in MLB.
• Jackson Chourio paces his team with a .421 slugging percentage. He has a batting average of .245 with an on-base percentage of .268.
• Including all qualifying hitters, his batting average places him 96th, his on-base percentage is 149th, and he is 77th in slugging.
• Brice Turang is hitting .280 with four doubles, four home runs and 21 walks.
• Sal Frelick has five doubles, three triples, three home runs and 17 walks while hitting .280.

Pirates vs Brewers Head to Head

• 5/22/2025: 8-5 MIL (Favorite: Brewers, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 9/26/2024: 5-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/25/2024: 2-1 PIT (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 9/24/2024: 7-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 7/11/2024: 1-0 PIT (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/10/2024: 9-0 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 7/9/2024: 12-2 PIT (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/15/2024: 10-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 5/14/2024: 4-3 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 5/13/2024: 8-6 PIT (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)

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