Padres vs Rays Prediction, Odds, Moneyline, Spread & Over/Under for April 26

Odds updated as of 8:13 p.m.

The San Diego Padres are among the MLB squads in action on Saturday, versus the Tampa Bay Rays.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Padres vs Rays Game Info

• San Diego Padres (17-9) vs. Tampa Bay Rays (12-14)
• Date: Saturday, April 26, 2025
• Time: 8:40 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and FDSSUN

Padres vs Rays Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-118) | TB: (-100)
• Spread: SD: +1.5 (-200) | TB: -1.5 (+164)
• Total: 7.5 -- Over: (-124) | Under: (+102)

Padres vs Rays Probable Starting Pitchers

Probable Pitchers: Dylan Edward Cease (Padres) - 1-1, 6.04 ERA vs Ryan Pepiot (Rays) - 1-3, 4.82 ERA

This contest's pitching matchup is set, as the Padres will send Dylan Edward Cease (1-1) to the mound, while Ryan Pepiot (1-3) will take the ball for the Rays. When Cease starts, his team is 2-3-0 against the spread this season. Cease's team is 3-1 this season when he starts and they are the moneyline favorite. The Rays did not cover in any of Pepiot's five starts that had a set spread. The Rays were the underdog on the moneyline for two Pepiot starts this season -- they lost both.

Padres vs Rays Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (56.6%)

Padres vs Rays Moneyline

• Looking at the moneyline for Padres-Rays, San Diego is the favorite at -118, and Tampa Bay is -100 playing on the road.

Padres vs Rays Spread

• The Rays are 1.5-run favorites against the spread for this matchup with the Padres. The Rays are +164 to cover, while the Padres are -200 to cover as a 1.5-run underdog on the runline.

Padres vs Rays Over/Under

• The Padres-Rays contest on April 26 has been given an over/under of 7.5 runs. The over is set at -124 and the under at +102.

Bet on San Diego Padres vs. Tampa Bay Rays on FanDuel today!

Padres vs Rays Betting Trends

• The Padres have come away with 10 wins in the 13 contests they have been listed as the favorites in this season.
• This year San Diego has won 10 of 13 games when listed as at least -118 on the moneyline.
• The Padres and their opponents have gone over the total this season in 10 of their 26 opportunities.
• In 26 games with a line this season, the Padres have a mark of 15-11-0 against the spread.
• The Rays have a 4-6 record in games they were the underdog on the moneyline (winning 40% of those games).
• Tampa Bay has a record of 4-4 when it has played as a moneyline underdog with odds of -100 or longer (50%).
• The Rays have combined with opponents to hit the over on the total 11 times this season for an 11-13-2 record against the over/under.
• The Rays have put together an 11-15-0 record ATS this season (covering 42.3% of the time).

Padres Player Leaders

• Fernando Tatis Jr. has 33 hits and an OBP of .409 to go with a slugging percentage of .629. All three of those stats are tops among San Diego hitters this season. He has a .340 batting average, as well.
• Among qualified hitters in MLB, he is fifth in batting average, 10th in on-base percentage, and fourth in slugging.
• Manny Machado has nine doubles, two home runs and 10 walks. He's batting .281 and slugging .438 with an on-base percentage of .349.
• Among qualifying batters, he ranks 43rd in batting average, 53rd in on-base percentage and 58th in slugging percentage.
• Xander Bogaerts has 22 hits this season and has a slash line of .250/.343/.341.
• Gavin Sheets has been key for San Diego with 21 hits, an OBP of .333 plus a slugging percentage of .472.

Rays Player Leaders

• Jonathan Aranda has accumulated a team-high OBP (.409), while pacing the Rays in hits (23). He's batting .311 and slugging.
• Including all qualifying players in the majors, he ranks 16th in batting average, 10th in on-base percentage and ninth in slugging percentage.
• Yandy (Fernandez) Diaz paces his team with a .398 slugging percentage. He has a batting average of .250 with an on-base percentage of .284.
• He is 75th in batting average, 117th in on-base percentage and 85th in slugging percentage in MLB.
• Kameron Misner is hitting .328 with seven doubles, a triple, three home runs and five walks.
• Junior Caminero is batting .250 with four doubles, five home runs and six walks.

Padres vs Rays Head to Head

• 4/25/2025: 1-0 TB (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 9/1/2024: 4-3 SD (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/31/2024: 11-4 TB (Favorite: Rays, Spread: -1.5, Total: 8, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/30/2024: 13-5 SD (Favorite: Rays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/18/2023: 5-4 SD (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 6/17/2023: 2-0 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/16/2023: 6-2 TB (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)

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