Padres vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for May 2

Odds updated as of 6:11 p.m.

The MLB schedule on Friday includes the San Diego Padres taking on the Pittsburgh Pirates.

All the information you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Padres vs Pirates Game Info

• San Diego Padres (19-11) vs. Pittsburgh Pirates (12-20)
• Date: Friday, May 2, 2025
• Time: 6:40 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: Apple TV+

Padres vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-148) | PIT: (+126)
• Spread: SD: -1.5 (+114) | PIT: +1.5 (-137)
• Total: 8 -- Over: (-114) | Under: (-106)

Padres vs Pirates Probable Starting Pitchers

Probable Pitchers: Dylan Cease (Padres) - 1-2, 5.76 ERA vs Mitch Keller (Pirates) - 1-2, 3.97 ERA

The Padres will give the nod to Dylan Cease (1-2) versus the Pirates and Mitch Keller (1-2). When Cease starts, his team is 2-4-0 against the spread this season. Cease's team is 3-2 this season when he starts and they are the moneyline favorite. The Pirates have gone 2-4-0 ATS in Keller's six starts that had a set spread. The Pirates are 1-2 in Keller's three starts this season that they were the moneyline underdog.

Padres vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (59.1%)

Padres vs Pirates Moneyline

• San Diego is the favorite, -148 on the moneyline, while Pittsburgh is a +126 underdog despite being at home.

Padres vs Pirates Spread

• The Pirates are +1.5 on the spread (-137 to cover), and San Diego is +114 to cover the runline.

Padres vs Pirates Over/Under

• The Padres-Pirates game on May 2 has been given an over/under of 8 runs. The over is set at -114 and the under at -106.

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Padres vs Pirates Betting Trends

• The Padres have won in 11, or 73.3%, of the 15 contests they have been named as odds-on favorites in this year.
• San Diego has not lost in seven games when named as a moneyline favorite of -148 or better.
• The Padres and their opponents have gone over the total this season in 12 of their 30 opportunities.
• In 30 games with a line this season, the Padres have a mark of 17-13-0 against the spread.
• The Pirates have gone 7-13 in games they were listed as the moneyline underdog (winning 35% of those games).
• When it has played as a moneyline underdog with odds of +126 or longer, Pittsburgh has gone 4-9 (30.8%).
• The Pirates have had an over/under set by oddsmakers 32 times, and have combined with opponents to go over the total in 15 of those games (15-16-1).
• The Pirates have a 12-20-0 record ATS this season (covering just 37.5% of the time).

Padres Player Leaders

• Fernando Tatis Jr. has 39 hits and an OBP of .409 to go with a slugging percentage of .602. All three of those stats are best among San Diego hitters this season. He has a .345 batting average, as well.
• He is third in batting average, eighth in on-base percentage, and seventh in slugging among all qualified batters in the majors.
• Manny Machado has 10 doubles, two home runs and 10 walks. He's batting .279 and slugging .423 with an on-base percentage of .336.
• He is 45th in batting average, 64th in on-base percentage and 71st in slugging in MLB.
• Machado has picked up at least one hit in two games in a row. In his last five games he is hitting .263 with a double and three RBI.
• Luis Arraez has collected 28 base hits, an OBP of .333 and a slugging percentage of .447 this season.
• Arraez takes a two-game hitting streak into this game. During his last five outings he is batting .429 with a triple, a home run, two walks and four RBI.
• Xander Bogaerts is batting .243 with a .331 OBP and eight RBI for San Diego this season.

Pirates Player Leaders

• Oneil Cruz has racked up an on-base percentage of .363 and has 26 hits, both team-best numbers for the Pirates. He's batting .252 and slugging .534.
• He is 76th in batting average, 41st in on-base percentage and 17th in slugging percentage among all qualified hitters in the majors.
• Andrew McCutchen is hitting .264 with six doubles, three home runs and 12 walks. He's slugging .437 with an on-base percentage of .354.
• Including all qualifying players, his batting average puts him 63rd, his on-base percentage ranks 50th, and he is 61st in slugging.
• Bryan Reynolds has a .373 slugging percentage, which paces the Pirates.
• Enmanuel Valdez has three doubles, two triples, two home runs and 11 walks while hitting .232.

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