Padres vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for May 2

Odds updated as of 11:11 a.m.

The MLB slate on Friday includes the San Diego Padres taking on the Pittsburgh Pirates.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info about this game.

Padres vs Pirates Game Info

• San Diego Padres (19-11) vs. Pittsburgh Pirates (12-20)
• Date: Friday, May 2, 2025
• Time: 6:40 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: Apple TV+

Padres vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-162) | PIT: (+136)
• Spread: SD: -1.5 (+106) | PIT: +1.5 (-128)
• Total: 7.5 -- Over: (-122) | Under: (-100)

Padres vs Pirates Probable Starting Pitchers

Probable Pitchers: Dylan Cease (Padres) - 1-2, 5.76 ERA vs Mitch Keller (Pirates) - 1-2, 3.97 ERA

The Padres will give the nod to Dylan Cease (1-2) versus the Pirates and Mitch Keller (1-2). Cease's team is 2-4-0 against the spread this season in his starts. Cease's team is 3-2 this season when he starts and they are the moneyline favorite. The Pirates have a 2-4-0 ATS record in Keller's six starts that had a set spread. The Pirates are 1-2 in Keller's three starts this season that they were the moneyline underdog.

Padres vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (59.1%)

Padres vs Pirates Moneyline

• The Padres vs Pirates moneyline has San Diego as a -162 favorite, while Pittsburgh is a +136 underdog at home.

Padres vs Pirates Spread

• The Pirates are at +1.5 on the runline against the Padres. The Pirates are -128 to cover the spread, and the Padres are +106.

Padres vs Pirates Over/Under

• The over/under for Padres-Pirates on May 2 is 7.5. The over is -122, and the under is -100.

Bet on San Diego Padres vs. Pittsburgh Pirates on FanDuel today!

Padres vs Pirates Betting Trends

• The Padres have been victorious in 11, or 73.3%, of the 15 contests they have been chosen as favorites in this season.
• San Diego has not lost in six games when named as a moneyline favorite of -162 or better.
• The Padres and their opponents have gone over the total this season in 12 of their 30 opportunities.
• The Padres have an against the spread mark of 17-13-0 in 30 games with a line this season.
• The Pirates have been the moneyline underdog 20 total times this season. They've gone 7-13 in those games.
• When it has played as a moneyline underdog with odds of +136 or longer, Pittsburgh has a 4-7 record (winning just 36.4% of its games).
• The Pirates have played in 32 games with an over/under set, and have combined with opponents to go over the total 15 times (15-16-1).
• The Pirates have put together a 12-20-0 record ATS this season (covering just 37.5% of the time).

Padres Player Leaders

• Fernando Tatis Jr. leads San Diego with 39 hits and an OBP of .409, plus a team-best slugging percentage of .602. He's batting .345.
• Among qualifying hitters in the majors, he is third in batting average, eighth in on-base percentage, and seventh in slugging.
• Manny Machado is hitting .279 with 10 doubles, two home runs and 10 walks, while slugging .423 with an on-base percentage of .336.
• He ranks 45th in batting average, 64th in on-base percentage and 71st in slugging among qualified hitters.
• Machado has picked up at least one hit in two games in a row. During his last five outings he is batting .263 with a double and three RBI.
• Luis Arraez has 28 hits this season and has a slash line of .298/.333/.447.
• Arraez enters this matchup with two games in a row with at least one hit. During his last five outings he is hitting .429 with a triple, a home run, two walks and four RBI.
• Xander Bogaerts has been key for San Diego with 25 hits, an OBP of .331 plus a slugging percentage of .350.

Pirates Player Leaders

• Oneil Cruz has 26 hits with a .363 on-base percentage, leading the Pirates in both statistics. He's batting .252 and slugging .534.
• He ranks 76th in batting average, 41st in on-base percentage and 17th in slugging percentage among all qualifying hitters in the majors.
• Andrew McCutchen has six doubles, three home runs and 12 walks while hitting .264. He's slugging .437 with an on-base percentage of .354.
• He is currently 63rd in batting average, 50th in on-base percentage and 61st in slugging percentage among all qualified hitters.
• Bryan Reynolds has racked up a team-high .373 slugging percentage.
• Enmanuel Valdez has three doubles, two triples, two home runs and 11 walks while batting .232.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!