San Francisco 49ers Vs. Indianapolis Colts Odds, Betting Lines, Score & Stats (December 22, 2025)

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Type

Passing Yards

Receiving Yards

Rushing Yards

Passing Touchdowns

Player

QB • 100 Average Yards

Player

QB • 100 Average Yards

Player

QB • 100 Average Yards

Player

QB • 100 Average Yards

Popular Bets

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4 Leg Parlay

+2000

Player

Any Time Touchdown Scorer

Player 40+ Yards

Player - Alt Rushing Yds

Player 250+ Yards

Player - Alt Passing Yds

Player 5+ Receptions

Player - Alt Receptions

1425 People Placed

4 Leg Parlay

+2000

Player

Any Time Touchdown Scorer

Player 40+ Yards

Player - Alt Rushing Yds

Player 250+ Yards

Player - Alt Passing Yds

Player 5+ Receptions

Player - Alt Receptions

1425 People Placed

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Top Projected Fantasy Performers

San Francisco 49ers

QBBrock Purdy

19.9 Points

RBChristian McCaffrey

19.7 Points

WRBrandon Aiyuk

11.3 Points

TEGeorge Kittle

10.0 Points

Indianapolis Colts

20.7 Points

19.3 Points

13.2 Points

10.0 Points

Injuries

San Francisco 49ers

NameStatus

WRTrent Taylor

IRUndisclosed

LBLuke Gifford

QHip

LBFred Warner

IRAnkle

KEddy Pineiro

QHamstring

RBPatrick Taylor Jr.

IRShoulder

DLNick Bosa

IRKnee - ACL

Indianapolis Colts

NameStatus

DTDeForest Buckner

IRNeck

OLBJacob Phillips

IRBiceps

RBSalvon Ahmed

IRAnkle

SAFDaniel Scott

IRKnee

WRD.J. Montgomery

IRUndisclosed

WRAshton Dulin

IRHamstring

Team Stats

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IND

Offensive EPA

Passing EPA

Rushing EPA

Defensive EPA

Def Pass EPA

Def Rush EPA

NFL

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More NFL Games

San Francisco 49ers

DateOpponentResultSpread

CARW 9 - 20-7.5

ARIW 41 - 22-3

LARL 42 - 26+3.5

NYGW 34 - 24-2.5

HOUL 15 - 26-1.5

ATLW 10 - 20-3

Indianapolis Colts

DateOpponentResultSpread

KCL 20 - 23+3.5

ATLW 25 - 31-5.5

PITL 20 - 27-3

TENW 14 - 38-14.5

LACW 38 - 24+1.5

ARIW 27 - 31-6.5

Popular Bets

Odds not available yet.

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4 Leg Parlay

+2000

Player

Any Time Touchdown Scorer

Player 40+ Yards

Player - Alt Rushing Yds

Player 250+ Yards

Player - Alt Passing Yds

Player 5+ Receptions

Player - Alt Receptions

1425 People Placed

4 Leg Parlay

+2000

Player

Any Time Touchdown Scorer

Player 40+ Yards

Player - Alt Rushing Yds

Player 250+ Yards

Player - Alt Passing Yds

Player 5+ Receptions

Player - Alt Receptions

1425 People Placed

Line Movement

These graphs show how the spread, moneyline, and total have shifted at FanDuel Sportsbook over time.

Spread

49ers

Open: -

Colts

Open: -

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Moneyline

49ers

Open: -

Colts

Open: -

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Total

Over

Open: -

Under

Open: -

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San Francisco 49ers

QBBrock Purdy

19.9 Points

RBChristian McCaffrey

19.7 Points

WRBrandon Aiyuk

11.3 Points

TEGeorge Kittle

10.0 Points

Indianapolis Colts

20.7 Points

19.3 Points

13.2 Points

10.0 Points

Odds not available yet.

Check back closer to game time!

Type

Passing Yards

Receiving Yards

Rushing Yards

Passing Touchdowns

Player

QB • 100 Average Yards

Player

QB • 100 Average Yards

Player

QB • 100 Average Yards

Player

QB • 100 Average Yards

San Francisco 49ers

NameStatus

WRTrent Taylor

IRUndisclosed

LBLuke Gifford

QHip

LBFred Warner

IRAnkle

KEddy Pineiro

QHamstring

RBPatrick Taylor Jr.

IRShoulder

DLNick Bosa

IRKnee - ACL

Indianapolis Colts

NameStatus

DTDeForest Buckner

IRNeck

OLBJacob Phillips

IRBiceps

RBSalvon Ahmed

IRAnkle

SAFDaniel Scott

IRKnee

WRD.J. Montgomery

IRUndisclosed

WRAshton Dulin

IRHamstring

IND

Offensive EPA

Passing EPA

Rushing EPA

Defensive EPA

Def Pass EPA

Def Rush EPA

San Francisco 49ers

DateOpponentResultSpread

CARW 9 - 20-7.5

ARIW 41 - 22-3

LARL 42 - 26+3.5

NYGW 34 - 24-2.5

HOUL 15 - 26-1.5

ATLW 10 - 20-3

Indianapolis Colts

DateOpponentResultSpread

KCL 20 - 23+3.5

ATLW 25 - 31-5.5

PITL 20 - 27-3

TENW 14 - 38-14.5

LACW 38 - 24+1.5

ARIW 27 - 31-6.5

ESPN

San Francisco 49ers

8-4 | 3rd in NFC West | 7th in NFC

SpreadMoneylineTotal

Indianapolis Colts

8-3 | 1st in AFC South | 3rd in AFC

SpreadMoneylineTotal

ESPN

Lucas Oil Stadium

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NFL

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Total

NFL

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