NFL Games This Week: Predictions, Odds, Picks, Best Bets for Week 13

The Houston Texans and the Indianapolis Colts hit the field for one of many exciting matchups on the NFL schedule in Week 13.

With Week 13 in the NFL upon us, stay on top of the latest betting odds with our preview below.

Lions vs. Packers

The league's second-ranked scoring offense, owned by the Detroit Lions (7-4), face the Green Bay Packers (7-3-1) and their fifth-ranked scoring defense on Thursday, Nov. 27 at 1 p.m. ET. The Lions put up 29.6 points per game, while the Packers give up 18.4 points per game.

• Game Preview: Green Bay Packers at Detroit Lions
• Projected Favorite: Lions (63.19% win probability)
• Spread: Detroit (-3)
• Total: 48.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Detroit vs. Green Bay with FanDuel Sportsbook.

Cowboys vs. Chiefs

Against the Dallas Cowboys (5-5-1), who sport the 30th-ranked pass defense this season, Patrick Mahomes and the Kansas City Chiefs (6-5) shouldn't have any trouble moving the ball through the air when the two teams come together on Thursday, Nov. 27 at 4:30 p.m. ET. Mahomes has been one of the NFL's top passers this season, ranking second-best in the league in passing yards.

• Game Preview: Kansas City Chiefs at Dallas Cowboys
• Projected Favorite: Chiefs (56.52% win probability)
• Spread: Kansas City (-3.5)
• Total: 52.5 -- Over: (-114) | Under: (-106)
• Time: 4:30 p.m. ET
• Channel: CBS

Bet on Dallas vs. Kansas City with FanDuel Sportsbook.

Ravens vs. Bengals

Ja'Marr Chase and the Cincinnati Bengals (3-8) play the Baltimore Ravens (6-5) on Thursday at 8:20 p.m. ET at M&T Bank Stadium.

• Game Preview: Cincinnati Bengals at Baltimore Ravens
• Projected Favorite: Ravens (77.76% win probability)
• Spread: Baltimore (-7.5)
• Total: 52.5 -- Over: (-104) | Under: (-118)
• Time: 8:20 p.m. ET
• Channel: NBC/Peacock

Bet on Baltimore vs. Cincinnati with FanDuel Sportsbook.

Eagles vs. Bears

When the Philadelphia Eagles (8-3) and the Chicago Bears (8-3) meet on Friday, Nov. 28 at 3 p.m. ET, the Eagles will be trying to rebound from a loss to the Cowboys, and the Bears will be looking to follow up their recent victory over the Steelers with another win.

• Game Preview: Chicago Bears at Philadelphia Eagles
• Projected Favorite: Eagles (62.29% win probability)
• Spread: Philadelphia (-7)
• Total: 44.5 -- Over: (-102) | Under: (-120)
• Time: 3 p.m. ET
• Channel: Amazon Prime Video

Bet on Philadelphia vs. Chicago with FanDuel Sportsbook.

Dolphins vs. Saints

De'Von Achane will lead the Miami Dolphins (4-7) into their matchup against the New Orleans Saints (2-9) at Hard Rock Stadium on Sunday at 1 p.m. ET.

• Game Preview: New Orleans Saints at Miami Dolphins
• Projected Favorite: Dolphins (59.26% win probability)
• Spread: Miami (-5.5)
• Total: 41.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Miami vs. New Orleans with FanDuel Sportsbook.

Jets vs. Falcons

The Atlanta Falcons (4-7), who secured the win against the Saints in their previous contest, visit the New York Jets (2-9) at MetLife Stadium on Nov. 30 at 1 p.m. ET. The Jets lost to the Ravens in their last game.

• Game Preview: Atlanta Falcons at New York Jets
• Projected Favorite: Falcons (58.40% win probability)
• Spread: Atlanta (-3)
• Total: 38.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on New York vs. Atlanta with FanDuel Sportsbook.

Colts vs. Texans

The Indianapolis Colts (8-3), who lead the league by scoring 31.0 points per game, will face a test from the second-ranked scoring defense of the Houston Texans (6-5), who allow opponents to score 16.5 per game. The game starts at 1 p.m. ET on Sunday, Nov. 30 at Lucas Oil Stadium.

• Game Preview: Houston Texans at Indianapolis Colts
• Projected Favorite: Colts (65.07% win probability)
• Spread: Indianapolis (-3)
• Total: 44.5 -- Over: (-112) | Under: (-108)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Indianapolis vs. Houston with FanDuel Sportsbook.

Titans vs. Jaguars

The Jacksonville Jaguars (7-4) are slated to take on the Tennessee Titans (1-10) at Nissan Stadium on Sunday, Nov. 30 at 1 p.m. ET. In their last games, the Jaguars defeated the Cardinals 27-24, and the Titans lost 30-24 to the Seahawks.

• Game Preview: Jacksonville Jaguars at Tennessee Titans
• Projected Favorite: Jaguars (71.12% win probability)
• Spread: Jacksonville (-5.5)
• Total: 42.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Tennessee vs. Jacksonville with FanDuel Sportsbook.

Browns vs. 49ers

One of the best running backs in football will be on display when Christian McCaffrey and the San Francisco 49ers (8-4) visit the Cleveland Browns (3-8) on Sunday, November 30, 2025.

• Game Preview: San Francisco 49ers at Cleveland Browns
• Projected Favorite: 49ers (62.40% win probability)
• Spread: San Francisco (-5.5)
• Total: 35.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Cleveland vs. San Francisco with FanDuel Sportsbook.

Panthers vs. Rams

The Los Angeles Rams (9-2) visit the Carolina Panthers (6-6) on Sunday at 1 p.m. ET, in a matchup between two excellent pass-catchers in Puka Nacua and Tetairoa McMillan.

• Game Preview: Los Angeles Rams at Carolina Panthers
• Projected Favorite: Rams (68.74% win probability)
• Spread: Los Angeles (-10.5)
• Total: 44.5 -- Over: (-118) | Under: (-104)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Carolina vs. Los Angeles with FanDuel Sportsbook.

Buccaneers vs. Cardinals

On Sunday at 1 p.m. ET, a pair of star pass-catchers will be featured when Emeka Egbuka and the Tampa Bay Buccaneers (6-5) host Trey McBride and the Arizona Cardinals (3-8).

• Game Preview: Arizona Cardinals at Tampa Bay Buccaneers
• Projected Favorite: Buccaneers (63.42% win probability)
• Spread: Tampa Bay (-3.5)
• Total: 44.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Tampa Bay vs. Arizona with FanDuel Sportsbook.

Seahawks vs. Vikings

The Seattle Seahawks (8-3), who defeated the Titans in their last tilt, host the Minnesota Vikings (4-7) at Lumen Field on Nov. 30 at 4:05 p.m. ET. The Vikings were defeated by the Packers in their last game.

• Game Preview: Minnesota Vikings at Seattle Seahawks
• Projected Favorite: Seahawks (83.78% win probability)
• Spread: Seattle (-11.5)
• Total: 41.5 -- Over: (-105) | Under: (-115)
• Time: 4:05 p.m. ET
• Channel: FOX

Bet on Seattle vs. Minnesota with FanDuel Sportsbook.

Chargers vs. Raiders

At 4:25 p.m. ET on Sunday, the Las Vegas Raiders (2-9) play at the Los Angeles Chargers (7-4).

• Game Preview: Las Vegas Raiders at Los Angeles Chargers
• Projected Favorite: Chargers (81.32% win probability)
• Spread: Los Angeles (-9.5)
• Total: 40.5 -- Over: (-115) | Under: (-105)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Los Angeles vs. Las Vegas with FanDuel Sportsbook.

Steelers vs. Bills

When the Buffalo Bills (7-4) and the Pittsburgh Steelers (6-5) match up on Sunday, Nov. 30 at 4:25 p.m. ET, they will both be looking to right the ship after losing their previous game. The Bills lost 23-19 to the Texans, and the Steelers are coming off a 31-28 loss to the Bears.

• Game Preview: Buffalo Bills at Pittsburgh Steelers
• Projected Favorite: Bills (59.96% win probability)
• Spread: Buffalo (-3)
• Total: 45.5 -- Over: (-110) | Under: (-110)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Pittsburgh vs. Buffalo with FanDuel Sportsbook.

Commanders vs. Broncos

On Sunday at 8:20 p.m. ET, the Washington Commanders (3-8) will host the Denver Broncos (9-2).

• Game Preview: Denver Broncos at Washington Commanders
• Projected Favorite: Broncos (68.04% win probability)
• Spread: Denver (-5.5)
• Total: 43.5 -- Over: (-105) | Under: (-115)
• Time: 8:20 p.m. ET
• Channel: NBC/Peacock

Bet on Washington vs. Denver with FanDuel Sportsbook.

Patriots vs. Giants

When the New England Patriots (10-2) and the New York Giants (2-10) match up on Monday, Dec. 1 at 8:15 p.m. ET, the Patriots will be looking to follow up their recent victory over the Bengals with another win, and the Giants will be attempting to bounce back from a loss to the Lions.

• Game Preview: New York Giants at New England Patriots
• Projected Favorite: Patriots (83.35% win probability)
• Spread: New England (-7.5)
• Total: 46.5 -- Over: (-110) | Under: (-110)
• Time: 8:15 p.m. ET
• Channel: ESPN

Bet on New England vs. New York with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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