NFL Games This Sunday: Predictions, Odds, Picks, Best Bets for Week 4

The Denver Broncos and the San Francisco 49ers take the field for one of many compelling matchups on the NFL's Sunday slate in Week 4.

Here is the betting info to break down ahead of Week 4 NFL Sunday.

Commanders vs. Colts

Jonathan Taylor will lead the Indianapolis Colts (1-2) into their game against the Washington Commanders (1-2) at Tottenham Hotspur Stadium on Sunday at 9:30 a.m. ET.

• Game Preview: Indianapolis Colts vs. Washington Commanders
• Projected Favorite: Colts (58.05% win probability)
• Spread: Indianapolis (-3.5)
• Total: 47.5 -- Over: (-112) | Under: (-108)
• Time: 9:30 a.m. ET
• Channel: NFL Network

Bet on Washington vs. Indianapolis with FanDuel Sportsbook.

Bears vs. Jets

The Chicago Bears (2-1) host the New York Jets (1-2) on Sunday at 1 p.m. ET, in a matchup between two of the top offensive performers in football in D'Andre Swift and Garrett Wilson.

• Game Preview: New York Jets at Chicago Bears
• Projected Favorite: Bears (70.21% win probability)
• Spread: Chicago (-3.5)
• Total: 42.5 -- Over: (-118) | Under: (-104)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Chicago vs. New York with FanDuel Sportsbook.

Buccaneers vs. Packers

The Green Bay Packers (1-2) and the Tampa Bay Buccaneers (0-3), who were both defeated in their last contest, will meet at 1 p.m. ET on Sunday, Oct. 4. In their previous games, the Packers lost 35-14 to the Falcons, and the Buccaneers were taken down by the Vikings 23-16.

• Game Preview: Green Bay Packers at Tampa Bay Buccaneers
• Projected Favorite: Packers (60.43% win probability)
• Spread: Green Bay (-3.5)
• Total: 38.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Tampa Bay vs. Green Bay with FanDuel Sportsbook.

Bills vs. Patriots

Josh Allen will lead the Buffalo Bills (3-0) into their battle versus the New England Patriots (1-2) at New Highmark Stadium on Sunday at 1 p.m. ET.

• Game Preview: New England Patriots at Buffalo Bills
• Projected Favorite: Bills (74.36% win probability)
• Spread: Buffalo (-6.5)
• Total: 48.5 -- Over: (-114) | Under: (-106)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Buffalo vs. New England with FanDuel Sportsbook.

Giants vs. Cardinals

A pair of star pass-catchers will be on display when Trey McBride and the Arizona Cardinals (1-2) visit Isaiah Likely and the New York Giants (2-1) on Sunday, October 4, 2026.

• Game Preview: Arizona Cardinals at New York Giants
• Projected Favorite: Cardinals (53.29% win probability)
• Spread: Arizona (-2.5)
• Total: 43.5 -- Over: (-118) | Under: (-104)
• Time: 1 p.m. ET
• Channel: CBS

Bet on New York vs. Arizona with FanDuel Sportsbook.

Ravens vs. Titans

The team with the NFL's fourth-ranked scoring offense, the Baltimore Ravens (2-1), host the Tennessee Titans (0-3) and their 30th-ranked scoring offense on Sunday, Oct. 4 at 1 p.m. ET. The Ravens produce 30.7 points per game, while the Titans average 12.3.

• Game Preview: Tennessee Titans at Baltimore Ravens
• Projected Favorite: Ravens (83.38% win probability)
• Spread: Baltimore (-11.5)
• Total: 42.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Baltimore vs. Tennessee with FanDuel Sportsbook.

Texans vs. Cowboys

One of the best pass-catchers in football will be on display when CeeDee Lamb and the Dallas Cowboys (1-2) visit the Houston Texans (0-3) on Sunday, October 4, 2026.

• Game Preview: Dallas Cowboys at Houston Texans
• Projected Favorite: Texans (62.55% win probability)
• Spread: Houston (-3)
• Total: 47.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Houston vs. Dallas with FanDuel Sportsbook.

Bengals vs. Jaguars

At 1 p.m. ET on Sunday, the Cincinnati Bengals (2-1) are at home against the Jacksonville Jaguars (2-1).

• Game Preview: Jacksonville Jaguars at Cincinnati Bengals
• Projected Favorite: Jaguars (53.08% win probability)
• Spread: Cincinnati (-2.5)
• Total: 51.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Cincinnati vs. Jacksonville with FanDuel Sportsbook.

Eagles vs. Rams

One of the top pass-catchers in football will be on show when Davante Adams and the Los Angeles Rams (1-2) visit the Philadelphia Eagles (2-1) on Sunday, October 4, 2026.

• Game Preview: Los Angeles Rams at Philadelphia Eagles
• Projected Favorite: Rams (56.12% win probability)
• Spread: Los Angeles (-3)
• Total: 43.5 -- Over: (-120) | Under: (-102)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Philadelphia vs. Los Angeles with FanDuel Sportsbook.

Vikings vs. Dolphins

The Minnesota Vikings (3-0) will host the Miami Dolphins (0-3) on Sunday at 4:05 p.m. ET.

• Game Preview: Miami Dolphins at Minnesota Vikings
• Projected Favorite: Vikings (69.85% win probability)
• Spread: Minnesota (-10.5)
• Total: 38.5 -- Over: (-115) | Under: (-105)
• Time: 4:05 p.m. ET
• Channel: FOX

Bet on Minnesota vs. Miami with FanDuel Sportsbook.

Raiders vs. Chiefs

Two of the best offensive players in football will be on display when running back Kenneth Walker III and the Kansas City Chiefs (3-0) visit quarterback Kirk Cousins and the Las Vegas Raiders (3-0) on Sunday, October 4, 2026.

• Game Preview: Kansas City Chiefs at Las Vegas Raiders
• Projected Favorite: Chiefs (64.95% win probability)
• Spread: Kansas City (-4.5)
• Total: 47.5 -- Over: (-108) | Under: (-112)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Las Vegas vs. Kansas City with FanDuel Sportsbook.

Seahawks vs. Chargers

With an offense that ranks 29th in the league at 14.7 points per game, the Los Angeles Chargers (0-3) have a tough road ahead against the Seattle Seahawks (2-1) and their third-ranked D (16.7 points surrendered per game). The two squads square off at 4:25 p.m. ET on Oct. 4.

• Game Preview: Los Angeles Chargers at Seattle Seahawks
• Projected Favorite: Seahawks (74.75% win probability)
• Spread: Seattle (-7)
• Total: 43.5 -- Over: (-106) | Under: (-114)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Seattle vs. Los Angeles with FanDuel Sportsbook.

49ers vs. Broncos

When the San Francisco 49ers (3-0) and the Denver Broncos (2-1) play on Sunday, Oct. 4 at 4:25 p.m. ET, they will both be looking to maintain momentum after winning their previous game. The 49ers won 36-30 versus the Cardinals, and the Broncos are coming off a 30-26 victory over the Rams.

• Game Preview: Denver Broncos at San Francisco 49ers
• Projected Favorite: 49ers (65.20% win probability)
• Spread: San Francisco (-2.5)
• Total: 47.5 -- Over: (-112) | Under: (-108)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on San Francisco vs. Denver with FanDuel Sportsbook.

Panthers vs. Lions

Look for plenty of points from the Carolina Panthers (1-2) when they host the Detroit Lions (2-1) at Bank of America Stadium on Oct. 4 at 8:20 p.m. ET. The Panthers are owners of the NFL's fifth-ranked scoring offense, while the Lions have the worst scoring defense in the league.

• Game Preview: Detroit Lions at Carolina Panthers
• Projected Favorite: Lions (62.48% win probability)
• Spread: Detroit (-3.5)
• Total: 50.5 -- Over: (-115) | Under: (-105)
• Time: 8:20 p.m. ET
• Channel: NBC/Peacock

Bet on Carolina vs. Detroit with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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