NFL Games This Sunday: Predictions, Odds, Picks, Best Bets for Week 3

The NFL Sunday lineup in Week 3 should provide some fireworks. The contests include the New England Patriots playing the Jacksonville Jaguars at EverBank Stadium.

Take a peek at our betting breakdown for the NFL's Week 3 action on Sunday.

Commanders vs. Seahawks

The Seattle Seahawks (2-0) are scheduled to square off against the Washington Commanders (0-2) at Northwest Stadium on Sunday, Sept. 27 at 1 p.m. ET. In their last contests, the Seahawks defeated the Cardinals 31-7, and the Commanders lost 37-20 to the Cowboys.

• Game Preview: Seattle Seahawks at Washington Commanders
• Projected Favorite: Seahawks (70.90% win probability)
• Spread: Seattle (-8.5)
• Total: 40.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Washington vs. Seattle with FanDuel Sportsbook.

Steelers vs. Bengals

The Cincinnati Bengals (2-0) are slated to match up with the Pittsburgh Steelers (1-1) at Acrisure Stadium on Sunday, Sept. 27 at 1 p.m. ET. In their last games, the Bengals took down the Texans 20-6, and the Steelers lost 20-3 to the Patriots.

• Game Preview: Cincinnati Bengals at Pittsburgh Steelers
• Projected Favorite: Bengals (51.00% win probability)
• Spread: Cincinnati (-3.5)
• Total: 42.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Pittsburgh vs. Cincinnati with FanDuel Sportsbook.

Colts vs. Texans

The Houston Texans (0-2) are scheduled to match up with the Indianapolis Colts (0-2) at Lucas Oil Stadium on Sunday, Sept. 27 at 1 p.m. ET. Both teams lost their last contest, as the Texans were defeated by the Bengals 20-6, and the Colts lost 33-30 to the Chiefs.

• Game Preview: Houston Texans at Indianapolis Colts
• Projected Favorite: Colts (55.85% win probability)
• Spread: Houston (-1.5)
• Total: 42.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Indianapolis vs. Houston with FanDuel Sportsbook.

Dolphins vs. Chiefs

Star running back Kenneth Walker III and the Kansas City Chiefs (2-0) play the Miami Dolphins (0-2) on Sunday at 1 p.m. ET at Hard Rock Stadium.

• Game Preview: Kansas City Chiefs at Miami Dolphins
• Projected Favorite: Chiefs (70.23% win probability)
• Spread: Kansas City (-9.5)
• Total: 45.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Miami vs. Kansas City with FanDuel Sportsbook.

Bills vs. Chargers

The Buffalo Bills (2-0), who took down the Lions in their previous game, host the Los Angeles Chargers (0-2) at New Highmark Stadium on Sept. 27 at 1 p.m. ET. The Chargers were defeated by the Raiders in their last game.

• Game Preview: Los Angeles Chargers at Buffalo Bills
• Projected Favorite: Bills (77.34% win probability)
• Spread: Buffalo (-7.5)
• Total: 50.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Buffalo vs. Los Angeles with FanDuel Sportsbook.

Giants vs. Titans

The New York Giants (1-1) are slated to match up with the Tennessee Titans (0-2) at MetLife Stadium on Sunday, Sept. 27 at 1 p.m. ET. Both squads lost their last game, as the Giants were defeated by the Rams 28-6, and the Titans lost 24-20 to the Eagles.

• Game Preview: Tennessee Titans at New York Giants
• Projected Favorite: Giants (66.24% win probability)
• Spread: New York (-2.5)
• Total: 37.5 -- Over: (-112) | Under: (-108)
• Time: 1 p.m. ET
• Channel: CBS

Bet on New York vs. Tennessee with FanDuel Sportsbook.

Lions vs. Jets

The Detroit Lions (1-1) are scheduled to match up with the New York Jets (1-1) at Ford Field on Sunday, Sept. 27 at 1 p.m. ET. Both squads lost their previous tilt, as the Lions were taken down by the Bills 41-31, and the Jets lost 20-17 to the Packers.

• Game Preview: New York Jets at Detroit Lions
• Projected Favorite: Lions (84.49% win probability)
• Spread: Detroit (-6.5)
• Total: 48.5 -- Over: (-112) | Under: (-108)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Detroit vs. New York with FanDuel Sportsbook.

Browns vs. Panthers

The Carolina Panthers (1-1) are slated to collide with the Cleveland Browns (1-1) at Huntington Bank Field on Sunday, Sept. 27 at 1 p.m. ET. Both teams won their previous tilt, as the Panthers defeated the Falcons 34-3, and the Browns won 23-19 versus the Buccaneers.

• Game Preview: Carolina Panthers at Cleveland Browns
• Projected Favorite: Panthers (54.38% win probability)
• Spread: Carolina (-2.5)
• Total: 41.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Cleveland vs. Carolina with FanDuel Sportsbook.

Jaguars vs. Patriots

EverBank Stadium is the venue where the Jacksonville Jaguars (1-1) will take on the New England Patriots (1-1) on Sunday, September 27, 2026.

• Game Preview: New England Patriots at Jacksonville Jaguars
• Projected Favorite: Jaguars (60.40% win probability)
• Spread: Jacksonville (-2.5)
• Total: 45.5 -- Over: (-120) | Under: (-102)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Jacksonville vs. New England with FanDuel Sportsbook.

49ers vs. Cardinals

At Levi's Stadium on Sunday, Brock Purdy and the San Francisco 49ers (2-0) play Trey McBride and the Arizona Cardinals (1-1) in a battle featuring two of the brightest stars in football, starting at 4:05 p.m. ET.

• Game Preview: Arizona Cardinals at San Francisco 49ers
• Projected Favorite: 49ers (80.80% win probability)
• Spread: San Francisco (-7.5)
• Total: 47.5 -- Over: (-118) | Under: (-104)
• Time: 4:05 p.m. ET
• Channel: FOX

Bet on San Francisco vs. Arizona with FanDuel Sportsbook.

Buccaneers vs. Vikings

One of the best pass-catchers in football will be on show when Justin Jefferson and the Minnesota Vikings (2-0) visit the Tampa Bay Buccaneers (0-2) on Sunday, September 27, 2026.

• Game Preview: Minnesota Vikings at Tampa Bay Buccaneers
• Projected Favorite: Buccaneers (52.07% win probability)
• Spread: Minnesota (-1.5)
• Total: 42.5 -- Over: (-115) | Under: (-105)
• Time: 4:05 p.m. ET
• Channel: FOX

Bet on Tampa Bay vs. Minnesota with FanDuel Sportsbook.

Saints vs. Raiders

The New Orleans Saints (1-1) and the Las Vegas Raiders (2-0), who both won their last game, will go head to head at 4:25 p.m. ET on Sunday, Sept. 27. In their previous games, the Saints won 24-17 against the Ravens, and the Raiders defeated the Chargers 26-14.

• Game Preview: Las Vegas Raiders at New Orleans Saints
• Projected Favorite: Saints (72.97% win probability)
• Spread: New Orleans (-3)
• Total: 43.5 -- Over: (-115) | Under: (-105)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on New Orleans vs. Las Vegas with FanDuel Sportsbook.

Cowboys vs. Ravens

A pair of the top offensive players in football will be featured when running back Derrick Henry and the Baltimore Ravens (1-1) take on QB Dak Prescott and the Dallas Cowboys (1-1) on Sunday, September 27, 2026.

• Game Preview: Baltimore Ravens vs. Dallas Cowboys
• Projected Favorite: Ravens (59.54% win probability)
• Spread: Baltimore (-3.5)
• Total: 52.5 -- Over: (-114) | Under: (-106)
• Time: 4:25 p.m. ET
• Channel: CBS/Paramount+

Bet on Dallas vs. Baltimore with FanDuel Sportsbook.

Broncos vs. Rams

The Los Angeles Rams (1-1) are set to do battle against the Denver Broncos (1-1) at Empower Field at Mile High on Sunday, Sept. 27 at 8:20 p.m. ET. Both squads won their previous game, as the Rams took down the Giants 28-6, and the Broncos won 20-13 versus the Jaguars.

• Game Preview: Los Angeles Rams at Denver Broncos
• Projected Favorite: Rams (50.85% win probability)
• Spread: Los Angeles (-1.5)
• Total: 44.5 -- Over: (-105) | Under: (-115)
• Time: 8:20 p.m. ET
• Channel: NBC/Peacock

Bet on Denver vs. Los Angeles with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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