Nationals vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for May 23

Odds updated as of 6:11 p.m.

The MLB slate on Friday includes the Washington Nationals taking on the San Francisco Giants.

All the info you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Nationals vs Giants Game Info

• Washington Nationals (23-27) vs. San Francisco Giants (29-21)
• Date: Friday, May 23, 2025
• Time: 6:45 p.m. ET
• Venue: Nationals Park -- Washington, District of Columbia
• Coverage: MASN2 and NBCS-BA

Nationals vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: WSH: (-112) | SF: (-104)
• Spread: WSH: +1.5 (-192) | SF: -1.5 (+158)
• Total: 8 -- Over: (-104) | Under: (-118)

Nationals vs Giants Probable Starting Pitchers

Probable Pitchers: MacKenzie Gore (Nationals) - 2-4, 3.67 ERA vs Landen Roupp (Giants) - 2-3, 4.30 ERA

This contest's pitching matchup is set, as the Nationals will send MacKenzie Gore (2-4) to the mound, while Landen Roupp (2-3) will take the ball for the Giants. Gore and his team are 4-6-0 ATS this season when he starts. When Gore starts a game and his team is the favorite on the moneyline, they have a record of 1-4. The Giants are 3-6-0 against the spread when Roupp starts. The Giants have been the moneyline underdog in five of Roupp's starts this season, and they went 2-3 in those matchups.

Nationals vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Nationals win (50.4%)

Nationals vs Giants Moneyline

• The moneyline numbers for Nationals vs. Giants reveal Washington as the favorite (-112) and San Francisco as the underdog (-104) on the road.

Nationals vs Giants Spread

• The Giants are 1.5-run favorites against the spread for this matchup with the Nationals. The Giants are +158 to cover, while the Nationals are -192 to cover as a 1.5-run underdog on the runline.

Nationals vs Giants Over/Under

• The over/under for the Nationals versus Giants contest on May 23 has been set at 8, with -104 odds on the over and -118 odds on the under.

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Nationals vs Giants Betting Trends

• The Nationals have won in two of the seven contests they have been named as odds-on favorites in this year.
• Washington has a record of 2-4 in contests when sportsbooks favor them by -112 or more on the moneyline.
• The Nationals and their opponents have gone over the total this season in 24 of their 48 opportunities.
• In 48 games with a line this season, the Nationals have a mark of 26-22-0 against the spread.
• The Giants have a 9-9 record in games they were listed as the moneyline underdog (winning 50% of those games).
• When playing as a moneyline underdog with odds of -104 or longer, San Francisco has gone 7-9 (43.8%).
• The Giants have had an over/under set by oddsmakers 50 times, and have combined with opponents to go over the total in 27 of those games (27-22-1).
• The Giants have collected a 24-26-0 record ATS this season (covering 48% of the time).

Nationals Player Leaders

• James Wood leads Washington with an OBP of .389, plus a team-best slugging percentage of .545. He's batting .291 on the season.
• Among qualified batters in MLB, he ranks 28th in batting average, 14th in on-base percentage, and 14th in slugging.
• Wood hopes to build on a five-game hitting streak in this matchup. In his last five games he is batting .529 with a double, a home run, five walks and eight RBIs.
• C.J. Abrams leads Washington in total hits (46) this season while batting .311 with 19 extra-base hits. He's slugging .561 with an on-base percentage of .372.
• He ranks 10th in batting average, 29th in on-base percentage and seventh in slugging in MLB.
• Abrams takes a four-game streak with at least one hit into this one. In his last five games he is batting .273 with two doubles, two home runs, a walk and three RBIs.
• Nathaniel Lowe is batting .222 with a .392 slugging percentage and 34 RBI this year.
• Lowe enters this game with two games in a row with at least one hit. During his last five outings he is hitting .190 with a double, a home run, a walk and four RBIs.
• Keibert Ruiz is batting .283 with a .328 OBP and 20 RBI for Washington this season.
• Ruiz has hit safely in four games in a row. During his last five outings he is batting .273 with three doubles and six RBIs.

Giants Player Leaders

• Jung Hoo Lee has 14 doubles, two triples, six home runs and 13 walks while batting .276. He's slugging .464 with an on-base percentage of .322.
• Including all qualifying hitters in the big leagues, his batting average places him 53rd, his on-base percentage ranks 89th, and he is 51st in slugging.
• Lee heads into this game on a three-game hitting streak. In his last five games he is batting .158 with two doubles, two walks and two RBIs.
• Heliot Ramos' 55 hits and .500 slugging percentage are both team-highs. He has a batting average of .296 with an on-base percentage of .362.
• He ranks 24th in batting average, 40th in on-base percentage and 29th in slugging percentage in the big leagues.
• Wilmer Flores is batting .257 with two doubles, 10 home runs and 16 walks.
• Matt Chapman is batting .217 with seven doubles, nine home runs and 32 walks.

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