Wednesday’s MLB Odds, Betting Lines and Predictions - May 21

The MLB lineup today should provide some fireworks. The outings include the Detroit Tigers taking on the St. Louis Cardinals at Busch Stadium. Check out at the article below, where we offer predictions for each and every game.

Today's MLB Odds and Predictions

Cincinnati Reds at Pittsburgh Pirates Odds, Lines & Predictions

Game Info

• When: 12:35 p.m. ET
• Where: PNC Park
• TV Channel: SportsNet PT and FDSOH
• Probable Pitchers: Andrew Heaney vs. Brady Singer
• Records: Pirates (16-33), Reds (25-25)
• Reds Moneyline Odds: -126
• Pirates Moneyline Odds: +108

numberFire Prediction

• numberFire Predicted Favorite: Reds
• Reds Win Probability: 54.62%
• Pirates Win Probability: 45.38%

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Baltimore Orioles at Milwaukee Brewers Odds, Lines & Predictions

Game Info

• When: 1:10 p.m. ET
• Where: American Family Field
• TV Channel: MLB Network, FDSWI and MASN2
• Probable Pitchers: Chad Patrick vs. Tomoyuki Sugano
• Records: Brewers (24-25), Orioles (15-32)
• Brewers Moneyline Odds: -124
• Orioles Moneyline Odds: +106

numberFire Prediction

• numberFire Predicted Favorite: Brewers
• Brewers Win Probability: 51.32%
• Orioles Win Probability: 48.68%

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Cleveland Guardians at Minnesota Twins

Game Info

• When: 1:10 p.m. ET
• Where: Target Field
• TV Channel: MNNT and CLEG
• Probable Pitchers: Bailey Ober vs. Logan Allen
• Records: Twins (26-21), Guardians (25-21)

numberFire Prediction

• numberFire Predicted Favorite: Twins
• Twins Win Probability: 63.15%
• Guardians Win Probability: 36.85%

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Houston Astros at Tampa Bay Rays Odds, Lines & Predictions

Game Info

• When: 1:10 p.m. ET
• Where: George M. Steinbrenner Field
• TV Channel: FDSSUN and SCHN
• Probable Pitchers: Taj Bradley vs. Hunter Brown
• Records: Rays (22-26), Astros (25-23)
• Astros Moneyline Odds: -142
• Rays Moneyline Odds: +120

numberFire Prediction

• numberFire Predicted Favorite: Astros
• Astros Win Probability: 55.87%
• Rays Win Probability: 44.13%

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Chicago Cubs at Miami Marlins Odds, Lines & Predictions

Game Info

• When: 1:10 p.m. ET
• Where: loanDepot park
• TV Channel: FDSFL and MARQ
• Probable Pitchers: Max Meyer vs. Cade Horton
• Records: Marlins (19-28), Cubs (29-20)
• Cubs Moneyline Odds: -132
• Marlins Moneyline Odds: +112

numberFire Prediction

• numberFire Predicted Favorite: Cubs
• Cubs Win Probability: 54.07%
• Marlins Win Probability: 45.93%

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Detroit Tigers at St. Louis Cardinals Odds, Lines & Predictions

Game Info

• When: 1:15 p.m. ET
• Where: Busch Stadium
• TV Channel: FDSMW and FDSDET
• Probable Pitchers: Andre Pallante vs. Brant Hurter
• Records: Cardinals (27-22), Tigers (32-17)
• Cardinals Moneyline Odds: -112
• Tigers Moneyline Odds: -104

numberFire Prediction

• numberFire Predicted Favorite: Cardinals
• Cardinals Win Probability: 58.12%
• Tigers Win Probability: 41.88%

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Seattle Mariners at Chicago White Sox Odds, Lines & Predictions

Game Info

• When: 2:10 p.m. ET
• Where: Rate Field
• TV Channel: CHSN and ROOT Sports NW
• Probable Pitchers: Shane Smith vs. Logan Evans
• Records: White Sox (15-34), Mariners (27-20)
• Mariners Moneyline Odds: -154
• White Sox Moneyline Odds: +130

numberFire Prediction

• numberFire Predicted Favorite: Mariners
• Mariners Win Probability: 62.43%
• White Sox Win Probability: 37.57%

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Cleveland Guardians at Minnesota Twins

Game Info

• When: 3:40 p.m. ET
• Where: Target Field
• TV Channel: MLB Network, MNNT and CLEG
• Probable Pitchers: Joe Ryan vs. Tanner Bibee
• Records: Twins (26-21), Guardians (25-21)

numberFire Prediction

• numberFire Predicted Favorite: Twins
• Twins Win Probability: 58.12%
• Guardians Win Probability: 41.88%

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Kansas City Royals at San Francisco Giants Odds, Lines & Predictions

Game Info

• When: 3:45 p.m. ET
• Where: Oracle Park
• TV Channel: NBCS-BA and FDSKC
• Probable Pitchers: Logan Webb vs.
• Records: Giants (28-20), Royals (27-22)
• Giants Moneyline Odds: -200
• Royals Moneyline Odds: +168

numberFire Prediction

• numberFire Predicted Favorite: Giants
• Giants Win Probability: 64.32%
• Royals Win Probability: 35.68%

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Atlanta Braves at Washington Nationals Odds, Lines & Predictions

Game Info

• When: 6:45 p.m. ET
• Where: Nationals Park
• TV Channel: MLB Network, MASN and FDSSO
• Probable Pitchers: Trevor Williams vs. AJ Smith-Shawver
• Records: Nationals (22-27), Braves (24-24)
• Braves Moneyline Odds: -162
• Nationals Moneyline Odds: +136

numberFire Prediction

• numberFire Predicted Favorite: Nationals
• Nationals Win Probability: 52.47%
• Braves Win Probability: 47.53%

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New York Mets at Boston Red Sox Odds, Lines & Predictions

Game Info

• When: 6:45 p.m. ET
• Where: Fenway Park
• TV Channel: MLB Network, NESN and SNY
• Probable Pitchers: Garrett Crochet vs. Tylor Megill
• Records: Red Sox (25-25), Mets (29-20)
• Red Sox Moneyline Odds: -144
• Mets Moneyline Odds: +122

numberFire Prediction

• numberFire Predicted Favorite: Red Sox
• Red Sox Win Probability: 52.10%
• Mets Win Probability: 47.90%

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Texas Rangers at New York Yankees Odds, Lines & Predictions

Game Info

• When: 7:05 p.m. ET
• Where: Yankee Stadium
• TV Channel: Amazon Prime Video and RSN
• Probable Pitchers: Ryan Yarbrough vs. Jacob deGrom
• Records: Yankees (28-19), Rangers (25-24)
• Yankees Moneyline Odds: -116
• Rangers Moneyline Odds: -102

numberFire Prediction

• numberFire Predicted Favorite: Yankees
• Yankees Win Probability: 57.21%
• Rangers Win Probability: 42.79%

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San Diego Padres at Toronto Blue Jays Odds, Lines & Predictions

Game Info

• When: 7:07 p.m. ET
• Where: Rogers Centre
• TV Channel: SN1 and SDPA
• Probable Pitchers: Kevin Gausman vs. Randy Vasquez
• Records: Blue Jays (23-24), Padres (27-19)
• Blue Jays Moneyline Odds: -148
• Padres Moneyline Odds: +126

numberFire Prediction

• numberFire Predicted Favorite: Padres
• Padres Win Probability: 50.82%
• Blue Jays Win Probability: 49.18%

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Philadelphia Phillies at Colorado Rockies Odds, Lines & Predictions

Game Info

• When: 8:40 p.m. ET
• Where: Coors Field
• TV Channel: COLR and NBCS-PH
• Probable Pitchers: Carson Palmquist vs. Taijuan Walker
• Records: Rockies (8-40), Phillies (30-18)
• Phillies Moneyline Odds: -225
• Rockies Moneyline Odds: +188

numberFire Prediction

• numberFire Predicted Favorite: Phillies
• Phillies Win Probability: 63.32%
• Rockies Win Probability: 36.68%

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Los Angeles Angels at Athletics Odds, Lines & Predictions

Game Info

• When: 10:05 p.m. ET
• Where: Sutter Health Park
• TV Channel: NBCS-CA and FDSW
• Probable Pitchers: JP Sears vs. Jack Kochanowicz
• Records: Athletics (22-26), Angels (21-25)
• Athletics Moneyline Odds: -158
• Angels Moneyline Odds: +134

numberFire Prediction

• numberFire Predicted Favorite: Athletics
• Athletics Win Probability: 60.78%
• Angels Win Probability: 39.22%

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Arizona Diamondbacks at Los Angeles Dodgers Odds, Lines & Predictions

Game Info

• When: 10:10 p.m. ET
• Where: Dodger Stadium
• TV Channel: SportsNet LA and ARID
• Probable Pitchers: Dustin May vs. Corbin Burnes
• Records: Dodgers (29-19), Diamondbacks (26-22)
• Dodgers Moneyline Odds: -138
• Diamondbacks Moneyline Odds: +118

numberFire Prediction

• numberFire Predicted Favorite: Dodgers
• Dodgers Win Probability: 53.09%
• Diamondbacks Win Probability: 46.91%

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All MLB win probability predictions and picks are according to numberFire.