Mariners vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 23

Odds updated as of 10:11 p.m.

The MLB's Wednesday slate includes the Seattle Mariners taking on the Houston Astros.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Mariners vs Astros Game Info

• Seattle Mariners (73-84) vs. Houston Astros (78-79)
• Date: Wednesday, September 23, 2026
• Time: 10:10 p.m. ET
• Venue: T-Mobile Park -- Seattle, Washington
• Coverage: ESPN

Mariners vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SEA: (-130) | HOU: (+110)
• Spread: SEA: -1.5 (+160) | HOU: +1.5 (-194)
• Total: 7.5 -- Over: (-115) | Under: (-105)

Mariners vs Astros Probable Starting Pitchers

Probable Pitchers: George Kirby (Mariners) - 9-11, 4.24 ERA vs Ethan Pecko (Astros) - 1-0, 3.77 ERA

The Mariners will give the ball to George Kirby (9-11, 4.24 ERA), who is eyeing win No. 10 on the season, and the Astros will turn to Ethan Pecko (1-0, 3.77 ERA). When Kirby starts, his team is 10-19-0 against the spread this season. When Kirby starts a game and his team is the favorite on the moneyline, they have a record of 13-13. The Astros are 3-1-0 against the spread when Pecko starts. The Astros were named the moneyline underdog for two Pecko starts this season -- they won both.

Mariners vs Astros Moneyline

• Looking at the moneyline for Mariners-Astros, Seattle is the favorite at -130, and Houston is +110 playing on the road.

Mariners vs Astros Spread

• The Mariners are 1.5-run home favorites on the runline against the Astros. The Mariners are +160 to cover, and the Astros are -194.

Mariners vs Astros Over/Under

• The over/under for Mariners-Astros on Sept. 23 is 7.5. The over is -115, and the under is -105.

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Mariners vs Astros Betting Trends

• The Mariners have won in 59, or 49.2%, of the 120 contests they have been named as odds-on favorites in this year.
• This year Seattle has won 47 of 85 games when listed as at least -130 on the moneyline.
• The Mariners and their opponents have gone over the total this season in 81 of their 155 opportunities.
• The Mariners have posted a record of 56-99-0 against the spread this season.
• The Astros have won 50% of the games this season they were the underdog on the moneyline (41-41).
• Houston has a 23-24 record (winning 48.9% of its games) when it has played as a moneyline underdog of +110 or longer.
• The Astros have combined with opponents to go over the total 76 times this season for a 76-74-7 record against the over/under.
• The Astros have collected a 78-79-0 record ATS this season.

Mariners Player Leaders

• Randy Arozarena leads Seattle OPS (.859) this season. He has a .279 batting average, an on-base percentage of .379, and a slugging percentage of .480.
• Among all qualifying hitters in baseball, his batting average ranks 26th, his on-base percentage ranks 10th, and he is 26th in slugging.
• Josh Naylor leads Seattle in slugging percentage (.356) thanks to 32 extra-base hits. He's batting .266 with an on-base percentage of .321.
• Among qualifying hitters, his batting average ranks him 47th, his on-base percentage 87th, and his slugging percentage 126th.
• Julio Rodriguez has collected 142 base hits, an OBP of .306 and a slugging percentage of .397 this season.
• Rodriguez brings a three-game hitting streak into this game. In his last five games he is batting .368 with two doubles and a walk.
• Cole Young is batting .246 with a .308 OBP and 65 RBI for Seattle this season.

Astros Player Leaders

• Yordan Alvarez has a team-high OBP (.431) and slugging percentage (.601), while pacing the Astros in hits (172, while batting .314).
• He ranks first in batting average, first in on-base percentage and first in slugging percentage among all qualifying hitters in the majors.
• Alvarez hopes to build on a seven-game hitting streak in this matchup. During his last 10 outings he is hitting .364 with three doubles, three home runs, seven walks and seven RBIs.
• Isaac Paredes is batting .262 with 26 doubles, a triple, 23 home runs and 68 walks. He's slugging .440 with an on-base percentage of .360.
• Including all qualifying hitters, he ranks 57th in batting average, 29th in on-base percentage and 53rd in slugging percentage.
• Christian Walker is hitting .221 with 25 doubles, a triple, 26 home runs and 48 walks.
• Jeremy Pena has 19 doubles, two triples, 20 home runs and 24 walks while batting .275.

Mariners vs Astros Head to Head

• 9/22/2026: 7-0 HOU (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 8/16/2026: 3-2 SEA (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +114)
• 8/15/2026: 10-5 SEA (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +110)
• 8/14/2026: 10-7 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -122, Underdog Moneyline: +112)
• 5/14/2026: 8-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/13/2026: 4-3 HOU (Favorite: Mariners, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 5/12/2026: 10-2 SEA (Favorite: Mariners, Spread: -1.5, Total: 8.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 5/11/2026: 3-1 SEA (Favorite: Mariners, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 4/13/2026: 6-2 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 4/12/2026: 6-1 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -190, Underdog Moneyline: +160)

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