Dodgers vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 23

Odds updated as of 10:11 p.m.

In MLB action on Wednesday, the Los Angeles Dodgers take on the San Diego Padres.

All the information you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Dodgers vs Padres Game Info

• Los Angeles Dodgers (97-60) vs. San Diego Padres (87-70)
• Date: Wednesday, September 23, 2026
• Time: 10:10 p.m. ET
• Venue: Dodger Stadium -- Los Angeles, California
• Coverage: SportsNet LA and Padres.TV

Dodgers vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LAD: (-225) | SD: (+188)
• Spread: LAD: -1.5 (-102) | SD: +1.5 (-118)
• Total: 8.5 -- Over: (+104) | Under: (-128)

Dodgers vs Padres Probable Starting Pitchers

Probable Pitchers: Yoshinobu Yamamoto (Dodgers) - 14-8, 2.51 ERA vs Robbie Ray (Padres) - 13-8, 3.60 ERA

This contest's pitching matchup is set, as the Dodgers will send Yoshinobu Yamamoto (14-8) to the mound, while Robbie Ray (13-8) will get the nod for the Padres. Yamamoto's team is 13-14-0 against the spread in his starts this season. When Yamamoto starts a game and his team is the favorite on the moneyline, they have a record of 18-8. When Ray starts, the Padres have gone 17-10-0 against the spread. The Padres are 5-7 in Ray's 12 starts this season that they were the underdog on the moneyline.

Dodgers vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Dodgers win (56.1%)

Dodgers vs Padres Moneyline

• The moneyline numbers for Dodgers vs. Padres reveal Los Angeles as the favorite (-225) and San Diego as the underdog (+188) on the road.

Dodgers vs Padres Spread

• The Dodgers are hosting the Padres and are favored by 1.5 runs on the spread. The Dodgers are -102 to cover the runline, with the Padres being -118.

Dodgers vs Padres Over/Under

• The over/under for Dodgers-Padres on Sept. 23 is 8.5. The over is +104, and the under is -128.

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Dodgers vs Padres Betting Trends

• The Dodgers have come away with 94 wins in the 149 contests they have been listed as the favorites in this season.
• This year Los Angeles has won 32 of 46 games when listed as at least -225 on the moneyline.
• The Dodgers and their opponents have gone over in 73 of their 155 games with a total set by sportsbooks this season.
• In 155 games with a line this season, the Dodgers have a mark of 66-89-0 against the spread.
• The Padres have won 47.3% of the games this season they were the underdog on the moneyline (35-39).
• San Diego has not won a game when entering as a moneyline underdog with odds of +188 or longer in four chances.
• The Padres have played in 157 games with an over/under set, and have combined with their opponents to go over the total 74 times (74-80-3).
• The Padres have covered 57.3% of their games this season, going 90-67-0 against the spread.

Dodgers Player Leaders

• Freddie Freeman leads Los Angeles with a slugging percentage of .439, fueled by 49 extra-base hits. He has a .293 batting average and an on-base percentage of .368.
• Among all qualified hitters in the majors, he is ninth in batting average, 17th in on-base percentage, and 56th in slugging.
• Freeman hopes to build on a two-game hitting streak in this matchup. During his last five outings he is hitting .300 with a walk and four RBIs.
• Kyle Tucker has 23 doubles, four triples, 17 home runs and 77 walks. He's batting .235 and slugging .392 with an on-base percentage of .333.
• Among qualifiers, he is 103rd in batting average, 65th in on-base percentage and 97th in slugging percentage.
• Mookie Betts is batting .259 with a .454 slugging percentage and 68 RBI this year.
• Andy Pages is batting .271 with a .339 OBP and 80 RBI for Los Angeles this season.

Padres Player Leaders

• Fernando Tatis Jr. has accumulated an on-base percentage of .354, a slugging percentage of .466, and has 174 hits, all club-bests for the Padres (while batting .285).
• He ranks 15th in batting average, 39th in on-base percentage and 34th in slugging percentage among all qualified hitters in the big leagues.
• Tatis takes a five-game hitting streak into this game. During his last five outings he is hitting .250 with a double, two home runs, two walks and three RBIs.
• Jackson Merrill has 25 doubles, five triples, 26 home runs and 40 walks while batting .254. He's slugging .442 with an on-base percentage of .302.
• He is currently 73rd in batting average, 116th in on-base percentage and 52nd in slugging percentage among all qualified batters.
• Manny Machado has 22 doubles, 28 home runs and 76 walks while hitting .218.
• Xander Bogaerts has 18 doubles, a triple, 12 home runs and 73 walks while batting .229.

Dodgers vs Padres Head to Head

• 9/22/2026: 7-0 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/5/2026: 5-2 SD (Favorite: Dodgers, Spread: -1.5, Total: 9.5, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 7/4/2026: 3-0 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -255, Underdog Moneyline: +210)
• 7/3/2026: 4-3 LAD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -260, Underdog Moneyline: +215)
• 7/2/2026: 12-7 LAD (Favorite: Dodgers, Spread: -1.5, Total: 9.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 6/28/2026: 4-2 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/27/2026: 15-3 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 6/26/2026: 7-1 SD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 5/20/2026: 4-0 LAD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 5/19/2026: 5-4 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8, Favorite Moneyline: -156, Underdog Moneyline: +132)

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