Dodgers vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 23

Odds updated as of 4:12 a.m.

The Los Angeles Dodgers versus the San Diego Padres is on the MLB schedule for Wednesday.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Dodgers vs Padres Game Info

• Los Angeles Dodgers (97-60) vs. San Diego Padres (87-70)
• Date: Wednesday, September 23, 2026
• Time: 10:10 p.m. ET
• Venue: Dodger Stadium -- Los Angeles, California
• Coverage: SportsNet LA and Padres.TV

Dodgers vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LAD: (-215) | SD: (+180)
• Spread: LAD: -1.5 (+100) | SD: +1.5 (-118)
• Total: 8.5 -- Over: (+100) | Under: (-122)

Dodgers vs Padres Probable Starting Pitchers

Probable Pitchers: Yoshinobu Yamamoto (Dodgers) - 14-8, 2.51 ERA vs Robbie Ray (Padres) - 13-8, 3.60 ERA

This contest's pitching matchup is set, as the Dodgers will send Yoshinobu Yamamoto (14-8) to the mound, while Robbie Ray (13-8) will answer the bell for the Padres. Yamamoto and his team have a record of 13-14-0 against the spread when he starts. Yamamoto's team is 18-8 this season when he starts and they are the moneyline favorite. The Padres have gone 17-10-0 ATS in Ray's 27 starts with a set spread. The Padres have a 5-7 record in Ray's 12 starts this season when they were the moneyline underdog.

Dodgers vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Dodgers win (61.2%)

Dodgers vs Padres Moneyline

• San Diego is a +180 underdog on the moneyline, while Los Angeles is a -215 favorite at home.

Dodgers vs Padres Spread

• The Dodgers are hosting the Padres and are favored by 1.5 runs (+100 to cover) on the runline. San Diego is -118 to cover.

Dodgers vs Padres Over/Under

• The Dodgers-Padres contest on Sept. 23 has been given an over/under of 8.5 runs. The over is set at +100 and the under at -122.

Bet on Los Angeles Dodgers vs. San Diego Padres on FanDuel today!

Dodgers vs Padres Betting Trends

• The Dodgers have been victorious in 94, or 63.1%, of the 149 contests they have been chosen as favorites in this season.
• This season Los Angeles has been victorious 37 times in 53 chances when named as a favorite of at least -215 on the moneyline.
• The Dodgers and their opponents have hit the over in 73 of their 155 games with a total set by oddsmakers this season.
• The Dodgers are 66-89-0 against the spread in their 155 games that had a posted line this season.
• The Padres have won 35 of the 74 games they were the underdog on the moneyline this season (47.3%).
• When playing as a moneyline underdog with odds of +180 or longer, San Diego has a record of 1-4 (20%).
• The Padres have played in 157 games with a set over/under, and have combined with opponents to go over the total 74 times (74-80-3).
• The Padres have a 90-67-0 record ATS this season (covering 57.3% of the time).

Dodgers Player Leaders

• Freddie Freeman leads Los Angeles with a slugging percentage of .439, fueled by 49 extra-base hits. He has a .293 batting average and an on-base percentage of .368.
• Among all qualified batters in MLB, he is ninth in batting average, 17th in on-base percentage, and 56th in slugging.
• Freeman hopes to build on a two-game hitting streak in this matchup. In his last five games he is batting .300 with a walk and four RBIs.
• Kyle Tucker is hitting .235 with 23 doubles, four triples, 17 home runs and 77 walks. He's slugging .392 with an on-base percentage of .333.
• Among qualifiers, he ranks 103rd in batting average, 65th in on-base percentage and 97th in slugging percentage.
• Mookie Betts has 119 hits this season and has a slash line of .259/.325/.454.
• Andy Pages is batting .271 with a .339 OBP and 80 RBI for Los Angeles this season.

Padres Player Leaders

• Fernando Tatis Jr. has racked up an on-base percentage of .354, a slugging percentage of .466, and has 174 hits, all club-highs for the Padres (while batting .285).
• He is 15th in batting average, 39th in on-base percentage and 34th in slugging percentage among all qualified hitters in MLB.
• Tatis takes a five-game hitting streak into this matchup. In his last five games he is hitting .250 with a double, two home runs, two walks and three RBIs.
• Jackson Merrill has 25 doubles, five triples, 26 home runs and 40 walks while batting .254. He's slugging .442 with an on-base percentage of .302.
• Including all qualifying hitters, his batting average places him 73rd, his on-base percentage ranks 115th, and he is 52nd in slugging.
• Manny Machado has 22 doubles, 28 home runs and 76 walks while hitting .218.
• Xander Bogaerts is hitting .229 with 18 doubles, a triple, 12 home runs and 73 walks.

Dodgers vs Padres Head to Head

• 9/22/2026: 7-0 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/5/2026: 5-2 SD (Favorite: Dodgers, Spread: -1.5, Total: 9.5, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 7/4/2026: 3-0 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -255, Underdog Moneyline: +210)
• 7/3/2026: 4-3 LAD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -260, Underdog Moneyline: +215)
• 7/2/2026: 12-7 LAD (Favorite: Dodgers, Spread: -1.5, Total: 9.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 6/28/2026: 4-2 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/27/2026: 15-3 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 6/26/2026: 7-1 SD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 5/20/2026: 4-0 LAD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 5/19/2026: 5-4 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8, Favorite Moneyline: -156, Underdog Moneyline: +132)

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