Cubs vs Marlins Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 23

Odds updated as of 7:12 p.m.

The Chicago Cubs versus the Miami Marlins is on the MLB schedule for Wednesday.

We've got you covered, in terms of the most important information regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Cubs vs Marlins Game Info

• Chicago Cubs (87-70) vs. Miami Marlins (77-80)
• Date: Wednesday, September 23, 2026
• Time: 7:40 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MARQ and Marlins.TV

Cubs vs Marlins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-180) | MIA: (+152)
• Spread: CHC: -1.5 (+130) | MIA: +1.5 (-156)
• Total: 6.5 -- Over: (-122) | Under: (+100)

Cubs vs Marlins Probable Starting Pitchers

Probable Pitchers: Kevin Gausman (Cubs) - 9-12, 4.55 ERA vs Ryan Gusto (Marlins) - 1-5, 4.14 ERA

The Cubs will give the ball to Kevin Gausman (9-12, 4.55 ERA), who is eyeing win No. 10 on the season, and the Marlins will turn to Ryan Gusto (1-5, 4.14 ERA). Gausman and his team are 13-18-0 ATS this season when he starts. Gausman's team has won 60% of his starts when they are favored on the moneyline (12-8). The Marlins have a 9-8-0 record against the spread in Gusto's starts. The Marlins are 7-5 in Gusto's 12 starts this season that they were the moneyline underdog.

Cubs vs Marlins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (63.3%)

Cubs vs Marlins Moneyline

• Looking at the moneyline for Marlins-Cubs, Miami is the underdog at +152, and Chicago is -180 playing at home.

Cubs vs Marlins Spread

• The Marlins are at the Cubs, and are +1.5 on the runline. The Marlins are +130 to cover the spread, and the Cubs are -156.

Cubs vs Marlins Over/Under

• A total of 6.5 runs has been set for the Cubs-Marlins game on Sept. 23, with the over available at -122 and the under at +100.

Bet on Chicago Cubs vs. Miami Marlins on FanDuel today!

Cubs vs Marlins Betting Trends

• The Cubs have been victorious in 59, or 56.7%, of the 104 contests they have been chosen as favorites in this season.
• This season Chicago has come away with a win nine times in 15 chances when named as a favorite of at least -180 on the moneyline.
• The Cubs' games have gone over the total in 87 of their 152 opportunities.
• The Cubs have posted a record of 73-79-0 against the spread this season.
• The Marlins have won 36 of the 89 games they were the moneyline underdog this season (40.4%).
• Miami is 4-8 (winning just 33.3% of its games) when it has played as a moneyline underdog of +152 or longer.
• The Marlins have had an over/under set by bookmakers 155 times, and have combined with opponents to go over the total in 80 of those games (80-73-2).
• The Marlins have an 80-75-0 record ATS this season (covering 51.6% of the time).

Cubs Player Leaders

• Pete Crow-Armstrong has 172 hits and an OBP of .373 to go with a slugging percentage of .579. All three of those stats lead Chicago hitters this season. He has a .282 batting average, as well.
• Among qualified hitters in baseball, his batting average ranks 20th, his on-base percentage ranks 13th, and he is second in slugging.
• Crow-Armstrong hopes to build on a two-game hitting streak in this matchup. During his last five outings he is batting .348 with two doubles, a triple, three home runs, three walks and five RBIs.
• Alex Bregman is hitting .262 with 32 doubles, two triples, 26 home runs and 75 walks. He's slugging .452 with an on-base percentage of .352.
• He is 57th in batting average, 41st in on-base percentage and 45th in slugging among qualifying hitters.
• Seiya Suzuki is batting .267 with a .471 slugging percentage and 85 RBI this year.
• Suzuki brings a four-game hitting streak into this game. During his last five outings he is hitting .261 with a double, a home run, a walk and four RBIs.
• Nico Hoerner is batting .264 with a .317 OBP and 71 RBI for Chicago this season.

Marlins Player Leaders

• Otto Lopez has a .440 slugging percentage, which paces the Marlins. He's batting .304 with an on-base percentage of .348.
• Including all the qualified players in the majors, he ranks fifth in batting average, 45th in on-base percentage and 53rd in slugging percentage.
• Javier Sanoja is hitting .293 with 31 doubles, five triples, 10 home runs and 27 walks. He's slugging .454 with an on-base percentage of .333.
• Xavier Edwards has put up a team-best .360 on-base percentage.
• Jakob Marsee is batting .231 with 19 doubles, six triples, 11 home runs and 77 walks.

Cubs vs Marlins Head to Head

• 9/22/2026: 8-2 MIA (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 9/6/2026: 10-3 MIA (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/5/2026: 6-5 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 9/4/2026: 6-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/21/2025: 2-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 5/20/2025: 14-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/19/2025: 8-7 MIA (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 5/14/2025: 3-1 MIA (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 5/13/2025: 5-4 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -260, Underdog Moneyline: +215)
• 5/12/2025: 5-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -255, Underdog Moneyline: +210)

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