Cubs vs Marlins Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 23

Odds updated as of 2:11 a.m.

The Chicago Cubs versus the Miami Marlins is on the MLB schedule for Wednesday.

All the info you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cubs vs Marlins Game Info

• Chicago Cubs (87-70) vs. Miami Marlins (77-80)
• Date: Wednesday, September 23, 2026
• Time: 7:40 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MARQ and Marlins.TV

Cubs vs Marlins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-178) | MIA: (+150)
• Spread: CHC: -1.5 (+132) | MIA: +1.5 (-162)
• Total: 6.5 -- Over: (-142) | Under: (+116)

Cubs vs Marlins Probable Starting Pitchers

Probable Pitchers: Kevin Gausman (Cubs) - 9-12, 4.55 ERA vs Ryan Gusto (Marlins) - 1-5, 4.14 ERA

The Cubs will give the nod to Kevin Gausman (9-12, 4.55 ERA), who is eyeing win No. 10 on the season, and the Marlins will counter with Ryan Gusto (1-5, 4.14 ERA). Gausman and his team have a record of 13-18-0 against the spread when he starts. When Gausman starts a game and his team is the favorite on the moneyline, they have a record of 12-8. When Gusto starts, the Marlins have gone 9-8-0 against the spread. The Marlins have a 7-5 record in Gusto's 12 starts this season when they were the underdog on the moneyline.

Cubs vs Marlins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (59.4%)

Cubs vs Marlins Moneyline

• The moneyline numbers for Cubs vs. Marlins reveal Chicago as the favorite (-178) and Miami as the underdog (+150) on the road.

Cubs vs Marlins Spread

• The Cubs are favored by 1.5 runs at home against the Marlins. The Cubs are +132 to cover the spread, while the Marlins are -162.

Cubs vs Marlins Over/Under

• Cubs versus Marlins on Sept. 23 has an over/under of 6.5 runs, with the odds on the over -142 and the under set at +116.

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Cubs vs Marlins Betting Trends

• The Cubs have been victorious in 59, or 56.7%, of the 104 contests they have been chosen as favorites in this season.
• Chicago has a record of 10-7 when favored by -178 or more this year.
• The Cubs and their opponents have gone over in 87 of their 152 games with a total set by sportsbooks this season.
• In 152 games with a line this season, the Cubs have a mark of 73-79-0 against the spread.
• The Marlins have been the underdog on the moneyline 89 total times this season. They've finished 36-53 in those games.
• Miami is 4-8 (winning only 33.3% of its games) when it has played as a moneyline underdog of +150 or longer.
• The Marlins have played in 155 games with an over/under set, and have combined with their opponents to go over the total 80 times (80-73-2).
• The Marlins are 80-75-0 against the spread this season.

Cubs Player Leaders

• Pete Crow-Armstrong leads Chicago in OBP (.373), slugging percentage (.579) and total hits (172) this season. He has a .282 batting average.
• Among qualifying hitters in the majors, his batting average ranks 21st, his on-base percentage ranks 13th, and he is second in slugging.
• Crow-Armstrong has picked up at least one hit in two games in a row. In his last five games he is hitting .348 with two doubles, a triple, three home runs, three walks and five RBIs.
• Alex Bregman has 32 doubles, two triples, 26 home runs and 75 walks. He's batting .262 and slugging .452 with an on-base percentage of .352.
• His batting average is 58th among qualified players, his on-base percentage 41st, and his slugging percentage 46th.
• Seiya Suzuki has collected 142 base hits, an OBP of .365 and a slugging percentage of .471 this season.
• Suzuki brings a four-game hitting streak into this matchup. In his last five games he is hitting .261 with a double, a home run, a walk and four RBIs.
• Nico Hoerner is batting .264 with a .317 OBP and 71 RBI for Chicago this season.

Marlins Player Leaders

• Otto Lopez has racked up a team-best .440 slugging percentage. He's batting .304 with an on-base percentage of .348.
• He is fifth in batting average, 45th in on-base percentage and 53rd in slugging percentage among all qualifying hitters in the big leagues.
• Javier Sanoja is hitting .293 with 31 doubles, five triples, 10 home runs and 27 walks. He's slugging .454 with an on-base percentage of .333.
• Xavier Edwards has put up a team-best .360 on-base percentage.
• Jakob Marsee has 19 doubles, six triples, 11 home runs and 77 walks while batting .231.

Cubs vs Marlins Head to Head

• 9/22/2026: 8-2 MIA (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 9/6/2026: 10-3 MIA (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/5/2026: 6-5 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 9/4/2026: 6-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/21/2025: 2-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 5/20/2025: 14-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/19/2025: 8-7 MIA (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 5/14/2025: 3-1 MIA (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 5/13/2025: 5-4 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -260, Underdog Moneyline: +215)
• 5/12/2025: 5-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -255, Underdog Moneyline: +210)

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