Houston vs Iowa State Basketball Prediction, Odds, Picks, Best Bets for February 22

Two streaking teams square off when the Houston Cougars (22-4, 14-1 Big 12) host the Iowa State Cyclones (21-5, 11-4 Big 12) on February 22, 2025. The Cougars will put their five-game win streak on the line against the Cyclones, who have won four straight.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Houston vs. Iowa State Game Info and Odds

• Game day: Saturday, February 22, 2025
• Game time: 2:00 PM ET
• TV channel: ESPN
• Location: Houston, Texas
• Arena: Fertitta Center

Houston vs. Iowa State Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Houston win (74.9%)

Houston is a 12.5-point favorite against Iowa State on Saturday and the over/under is set at 130.5 points. Keep reading for a few betting insights and trends before you place a wager on the game.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Houston vs. Iowa State: ATS Betting Stats and Trends

• Houston has put together a 16-10-0 ATS record so far this year.
• Iowa State has won 15 games against the spread this season, while failing to cover 11 times.
• In home games, the Cougars have a worse record against the spread (10-4-0) compared to their ATS record in road games (6-2-0).
• The Cyclones have been better against the spread on the road (5-3-0) than at home (8-7-0) this season.
• Against the spread, in conference action, Houston is 11-4-0 this season.
• Iowa State is 10-6-0 against the spread in Big 12 action this season.

Houston vs. Iowa State: Moneyline Betting Stats

• Houston has won in 21, or 84%, of the 25 contests it has been named as the moneyline favorite in this year.
• This season, the Cougars have been victorious 13 times in 14 chances when named as a favorite of at least -847 or better on the moneyline.
• Iowa State has been the underdog on the moneyline four total times this season. Iowa State has gone 1-3 in those games.
• The Cyclones have yet to play a game with moneyline odds of +570 or longer.
• The moneyline set for this matchup implies Houston has a 89.4% chance of coming away with a victory in the contest.

Houston vs. Iowa State Head-to-Head Comparison

• Houston is outscoring opponents by 17.8 points per game with a +462 scoring differential overall. It puts up 75.4 points per game (139th in college basketball) and allows 57.6 per contest (first in college basketball).
• LJ Cryer leads Houston, averaging 14.5 points per game (316th in college basketball).
• Iowa State's +375 scoring differential (outscoring opponents by 14.4 points per game) is a result of putting up 81.3 points per game (30th in college basketball) while giving up 66.9 per contest (50th in college basketball).
• Iowa State's leading scorer, Curtis Jones, is 105th in college basketball, putting up 17.2 points per game.
• The Cougars win the rebound battle by an average of 7.6 boards. They are recording 33.4 rebounds per game (101st in college basketball) compared to their opponents' 25.8 per contest.
• J'wan Roberts' 6.4 rebounds per game lead the Cougars and rank 246th in college basketball play.
• The Cyclones rank 77th in college basketball at 34 rebounds per game. That's 6.1 more than the 27.9 their opponents average.
• Joshua Jefferson's 7.9 rebounds per game lead the Cyclones and rank 68th in college basketball.
• Houston averages 103.6 points per 100 possessions on offense (29th in college basketball), and allows 79.2 points per 100 possessions (first in college basketball).
• The Cyclones average 103.2 points per 100 possessions on offense (37th in college basketball), and concede 84.9 points per 100 possessions (18th in college basketball).

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!