Guardians vs Royals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 26

Odds updated as of 6:12 p.m.

MLB action on Saturday includes the Cleveland Guardians taking on the Kansas City Royals.

All the info you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Guardians vs Royals Game Info

• Cleveland Guardians (84-76) vs. Kansas City Royals (68-92)
• Date: Saturday, September 26, 2026
• Time: 7:10 p.m. ET
• Venue: Kauffman Stadium -- Kansas City, Missouri
• Coverage: Royals.TV and CleGuardians.TV

Guardians vs Royals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-142) | KC: (+120)
• Spread: CLE: -1.5 (+125) | KC: +1.5 (-150)
• Total: 7.5 -- Over: (+106) | Under: (-130)

Guardians vs Royals Probable Starting Pitchers

Probable Pitchers: Tanner Bibee (Guardians) - 6-15, 4.35 ERA vs Michael Wacha (Royals) - 9-9, 3.33 ERA

The Guardians will call on Tanner Bibee (6-15) against the Royals and Michael Wacha (9-9). Bibee and his team are 9-21-0 ATS this season when he starts. Bibee's team has been victorious in 33.3% of the games he's started as the moneyline favorite with a record of 5-10. When Wacha starts, the Royals have gone 15-14-0 against the spread. The Royals have a 4-13 record in Wacha's 17 starts this season when they were the moneyline underdog.

Guardians vs Royals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Royals win (52.9%)

Guardians vs Royals Moneyline

• Looking at the moneyline for Guardians-Royals, Cleveland is the favorite at -142, and Kansas City is +120 playing at home.

Guardians vs Royals Spread

• The Guardians are favored by 1.5 runs on the road versus the Royals. The Guardians are +125 to cover the spread, while the Royals are -150.

Guardians vs Royals Over/Under

• A combined run total of 7.5 has been set for Guardians-Royals on Sept. 26, with the over at +106 and the under at -130.

Bet on Cleveland Guardians vs. Kansas City Royals on FanDuel today!

Guardians vs Royals Betting Trends

• The Guardians have been chosen as favorites in 89 games this year and have walked away with the win 47 times (52.8%) in those games.
• Cleveland has a record of 22-12 in contests when oddsmakers favor them by -142 or more on the moneyline.
• Contests with the Guardians have gone over the total set by oddsmakers in 73 of 150 chances this season.
• The Guardians are 72-78-0 against the spread in their 150 games with a line set by sportsbooks this season.
• The Royals have won 38.6% of the games this season they were the underdog on the moneyline (39-62).
• Kansas City has a 14-27 record (winning just 34.1% of its games) when playing as a moneyline underdog of +120 or longer.
• The Royals have had an over/under set by oddsmakers 152 times, and have combined with opponents to go over the total in 70 of those games (70-79-3).
• The Royals have collected a 76-76-0 record ATS this season (covering 50% of the time).

Guardians Player Leaders

• Chase DeLauter has 141 hits, which is tops among Cleveland hitters this season, while batting .287 with 48 extra-base hits. He has an on-base percentage of .363 and a slugging percentage of .452.
• Among the qualified hitters in the majors, his batting average ranks 13th, his on-base percentage ranks 25th, and he is 42nd in slugging.
• Steven Kwan is slashing .279/.379/.342 this season and leads the Guardians with an OPS of .721.
• He ranks 27th in batting average, 10th in on-base percentage and 131st in slugging in the major leagues.
• Jose Ramirez has 111 hits this season and has a slash line of .237/.323/.372.
• Ramirez has logged a hit or more in two straight games. In his last five games he is batting .300 with a double, two walks and two RBIs.
• Brayan Rocchio has 13 home runs, 71 RBI and a batting average of .249 this season.

Royals Player Leaders

• Bobby Witt Jr. has accumulated an on-base percentage of .361 and a slugging percentage of .442. Both lead the Royals. He's batting .282.
• Including all the qualified hitters in MLB, his batting average is 17th, his on-base percentage ranks 28th, and he is 51st in slugging.
• Witt takes a seven-game hitting streak into this game. In his last 10 games he is hitting .308 with two doubles and four walks.
• Carter Jensen is hitting .237 with 33 doubles, two triples, 27 home runs and 64 walks. He's slugging .463 with an on-base percentage of .321.
• His batting average ranks 102nd among all qualified players, his on-base percentage ranks 83rd, and he is 37th in slugging.
• Jac Caglianone has 144 hits, a team-best for the Royals.
• Vinnie Pasquantino has 20 doubles, two triples, 15 home runs and 51 walks while hitting .246.

Guardians vs Royals Head to Head

• 8/30/2026: 11-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -178, Underdog Moneyline: +164)
• 8/29/2026: 8-3 KC (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +146)
• 8/28/2026: 3-0 KC (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +120)
• 5/7/2026: 8-5 CLE (Favorite: Royals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 5/6/2026: 3-1 CLE (Favorite: Royals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 5/5/2026: 5-3 KC (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/4/2026: 6-2 KC (Favorite: Royals, Spread: -1.5, Total: 9, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 4/8/2026: 10-2 CLE (Favorite: Royals, Spread: -1.5, Total: 7, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/7/2026: 2-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 4/6/2026: 4-2 KC (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -118, Underdog Moneyline: +100)

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