Guardians vs Royals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 26

Odds updated as of 2:11 a.m.

The MLB slate on Saturday includes the Cleveland Guardians facing the Kansas City Royals.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information about this game.

Guardians vs Royals Game Info

• Cleveland Guardians (84-76) vs. Kansas City Royals (68-92)
• Date: Saturday, September 26, 2026
• Time: 7:10 p.m. ET
• Venue: Kauffman Stadium -- Kansas City, Missouri
• Coverage: Royals.TV and CleGuardians.TV

Guardians vs Royals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-142) | KC: (+120)
• Spread: CLE: -1.5 (+125) | KC: +1.5 (-150)
• Total: 7.5 -- Over: (+106) | Under: (-130)

Guardians vs Royals Probable Starting Pitchers

Probable Pitchers: Tanner Bibee (Guardians) - 6-15, 4.35 ERA vs Michael Wacha (Royals) - 9-9, 3.33 ERA

The Guardians will give the nod to Tanner Bibee (6-15, 4.35 ERA), who is eyeing win No. 7 on the season, and the Royals will turn to Michael Wacha (9-9, 3.33 ERA). Bibee and his team have a record of 9-21-0 against the spread when he starts. Bibee's team has been victorious in 33.3% of the games he's started as the moneyline favorite with a record of 5-10. When Wacha starts, the Royals have gone 15-14-0 against the spread. The Royals are 4-13 in Wacha's 17 starts this season that they were the moneyline underdog.

Guardians vs Royals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Royals win (52.5%)

Guardians vs Royals Moneyline

• Looking at the moneyline for Royals-Guardians, Kansas City is the underdog at +120, and Cleveland is -142 playing on the road.

Guardians vs Royals Spread

• The Guardians are favored by 1.5 runs on the road versus the Royals. The Guardians are +125 to cover the spread, while the Royals are -150.

Guardians vs Royals Over/Under

• Guardians versus Royals on Sept. 26 has an over/under of 7.5 runs, with the odds on the over +106 and the under set at -130.

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Guardians vs Royals Betting Trends

• The Guardians have won in 47, or 52.8%, of the 89 contests they have been named as odds-on favorites in this year.
• This season Cleveland has been victorious 22 times in 34 chances when named as a favorite of at least -142 on the moneyline.
• The Guardians and their opponents have hit the over in 73 of their 150 games with a total set by oddsmakers this season.
• In 150 games with a line this season, the Guardians have a mark of 72-78-0 against the spread.
• The Royals have won 38.6% of the games this season they were the moneyline underdog (39-62).
• Kansas City has a 14-27 record (winning only 34.1% of its games) when it has played as a moneyline underdog of +120 or longer.
• The Royals have played in 152 games with a set over/under, and have combined with their opponents to go over the total 70 times (70-79-3).
• The Royals have collected a 76-76-0 record ATS this season.

Guardians Player Leaders

• Chase DeLauter has 141 hits, which leads Cleveland hitters this season, while batting .287 with 48 extra-base hits. He has an on-base percentage of .363 and a slugging percentage of .452.
• He is 13th in batting average, 25th in on-base percentage, and 42nd in slugging among qualifying hitters in MLB.
• Steven Kwan is slashing .279/.379/.342 this season and leads the Guardians with an OPS of .721.
• Among qualifying hitters, his batting average places him 26th, his on-base percentage 10th, and his slugging percentage 131st.
• Jose Ramirez is batting .237 with a .372 slugging percentage and 53 RBI this year.
• Ramirez heads into this game with two games in a row with at least one hit. In his last five games he is batting .300 with a double, two walks and two RBIs.
• Brayan Rocchio is batting .249 with a .310 OBP and 71 RBI for Cleveland this season.

Royals Player Leaders

• Bobby Witt Jr. has put up a .361 on-base percentage and a .442 slugging percentage, both team-best marks for the Royals. He's batting .282.
• Including all qualified players in MLB, his batting average places him 17th, his on-base percentage ranks 28th, and he is 51st in slugging.
• Witt hopes to build on a seven-game hitting streak in this matchup. During his last 10 games he is hitting .308 with two doubles and four walks.
• Carter Jensen has 33 doubles, two triples, 27 home runs and 64 walks while batting .237. He's slugging .463 with an on-base percentage of .321.
• Including all qualified hitters, his batting average places him 102nd, his on-base percentage ranks 83rd, and he is 37th in slugging.
• Jac Caglianone has racked up 144 hits, a team-high for the Royals.
• Vinnie Pasquantino is hitting .246 with 20 doubles, two triples, 15 home runs and 51 walks.

Guardians vs Royals Head to Head

• 8/30/2026: 11-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -178, Underdog Moneyline: +164)
• 8/29/2026: 8-3 KC (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +146)
• 8/28/2026: 3-0 KC (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +120)
• 5/7/2026: 8-5 CLE (Favorite: Royals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 5/6/2026: 3-1 CLE (Favorite: Royals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 5/5/2026: 5-3 KC (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/4/2026: 6-2 KC (Favorite: Royals, Spread: -1.5, Total: 9, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 4/8/2026: 10-2 CLE (Favorite: Royals, Spread: -1.5, Total: 7, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/7/2026: 2-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 4/6/2026: 4-2 KC (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -118, Underdog Moneyline: +100)

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