Brewers vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 26

Odds updated as of 2:11 a.m.

MLB action on Saturday includes the Milwaukee Brewers playing the St. Louis Cardinals.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Brewers vs Cardinals Game Info

• Milwaukee Brewers (101-59) vs. St. Louis Cardinals (77-83)
• Date: Saturday, September 26, 2026
• Time: 7:10 p.m. ET
• Venue: American Family Field -- Milwaukee, Wisconsin
• Coverage: Brewers.TV and Cardinals.TV

Brewers vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-188) | STL: (+158)
• Spread: MIL: -1.5 (+125) | STL: +1.5 (-150)
• Total: 7.5 -- Over: (-122) | Under: (+100)

Brewers vs Cardinals Probable Starting Pitchers

Probable Pitchers: Dustin May (Brewers) - 7-9, 4.67 ERA vs Quinn Mathews (Cardinals) - 2-3, 3.65 ERA

The Brewers will give the nod to Dustin May (7-9, 4.67 ERA), who is eyeing win No. 8 on the season, and the Cardinals will turn to Quinn Mathews (2-3, 3.65 ERA). When May starts, his team is 14-16-0 against the spread this season. May's team has won 60% of his starts when they are favored on the moneyline (9-6). The Cardinals are 3-5-0 against the spread when Mathews starts. The Cardinals have a 1-3 record in Mathews' four starts this season when they were the moneyline underdog.

Brewers vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (65.7%)

Brewers vs Cardinals Moneyline

• Looking at the moneyline for Cardinals-Brewers, St. Louis is the underdog at +158, and Milwaukee is -188 playing at home.

Brewers vs Cardinals Spread

• The Cardinals are +1.5 on the run line against the Brewers. The Cardinals are -150 to cover, and the Brewers are +125.

Brewers vs Cardinals Over/Under

• A combined run total of 7.5 has been set for Brewers-Cardinals on Sept. 26, with the over at -122 and the under at +100.

Bet on Milwaukee Brewers vs. St. Louis Cardinals on FanDuel today!

Brewers vs Cardinals Betting Trends

• The Brewers have been favorites in 123 games this season and have come away with the win 80 times (65%) in those contests.
• This season Milwaukee has come away with a win 21 times in 28 chances when named as a favorite of at least -188 on the moneyline.
• The Brewers and their opponents have gone over in 70 of their 159 games with a total set by sportsbooks this season.
• The Brewers are 83-76-0 against the spread in their 159 games that had a posted line this season.
• The Cardinals are 46-55 in games they were the underdog on the moneyline (winning 45.5% of those games).
• St. Louis is 5-9 (winning just 35.7% of its games) when playing as a moneyline underdog of +158 or longer.
• The Cardinals have had an over/under set by oddsmakers 156 times, and have combined with opponents to go over the total in 72 of those games (72-77-7).
• The Cardinals have collected an 83-73-0 record against the spread this season (covering 53.2% of the time).

Brewers Player Leaders

• Brice Turang leads Milwaukee in slugging percentage (.449) thanks to 60 extra-base hits. He has a .270 batting average and an on-base percentage of .367.
• Among all qualifying hitters in the majors, his batting average ranks 41st, his on-base percentage ranks 19th, and he is 46th in slugging.
• Turang has recorded at least one hit in four games in a row. During his last five outings he is batting .318 with three doubles, a home run and four RBIs.
• William Contreras is batting .270 with 27 doubles, a triple, 18 home runs and 60 walks. He's slugging .417 with an on-base percentage of .340.
• Among qualified hitters, he ranks 41st in batting average, 54th in on-base percentage and 77th in slugging percentage.
• Jake Bauers leads Milwaukee with 126 hits and an OBP of .391 this season.
• Bauers has recorded a hit in two straight games. During his last five outings he is hitting .263 with two doubles, two walks and three RBIs.
• Jackson Chourio is batting .286 with a .347 OBP and 72 RBI for Milwaukee this season.
• Chourio takes a three-game hitting streak into this matchup. During his last five outings he is batting .333 with a home run, four walks and two RBIs.

Cardinals Player Leaders

• Alec Burleson has racked up a slugging percentage of .469, a team-best for the Cardinals. He's batting .280 with an on-base percentage of .344.
• Including all the qualifying hitters in the majors, his batting average ranks 23rd, his on-base percentage is 49th, and he is 34th in slugging.
• Burleson hopes to build on a three-game hitting streak in this matchup. In his last five games he is hitting .158 with two home runs and four RBIs.
• Jordan Walker's 163 hits lead his team. He has a batting average of .271 while slugging .471 with an on-base percentage of .329.
• Including all qualifying hitters, he is 40th in batting average, 70th in on-base percentage and 33rd in slugging percentage.
• Ivan Herrera a has .355 on-base percentage to pace the Cardinals.
• JJ Wetherholt is batting .244 with 15 doubles, 17 home runs and 64 walks.

Brewers vs Cardinals Head to Head

• 9/25/2026: 8-4 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 7/9/2026: 8-4 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 7/8/2026: 5-1 STL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 7/7/2026: 10-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/7/2026: 4-3 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 7/6/2026: 4-3 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 5/27/2026: 2-1 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/26/2026: 6-0 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 5/25/2026: 5-1 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 5/6/2026: 6-2 MIL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)

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