Brewers vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 26

Odds updated as of 6:12 p.m.

The Milwaukee Brewers are among the MLB teams in action on Saturday, up against the St. Louis Cardinals.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info about this matchup.

Brewers vs Cardinals Game Info

• Milwaukee Brewers (101-59) vs. St. Louis Cardinals (77-83)
• Date: Saturday, September 26, 2026
• Time: 7:10 p.m. ET
• Venue: American Family Field -- Milwaukee, Wisconsin
• Coverage: Brewers.TV and Cardinals.TV

Brewers vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-164) | STL: (+138)
• Spread: MIL: -1.5 (+130) | STL: +1.5 (-156)
• Total: 7.5 -- Over: (-115) | Under: (-105)

Brewers vs Cardinals Probable Starting Pitchers

Probable Pitchers: Dustin May (Brewers) - 7-9, 4.67 ERA vs Quinn Mathews (Cardinals) - 2-3, 3.65 ERA

The probable starters are Dustin May (7-9) for the Brewers and Quinn Mathews (2-3) for the Cardinals. May and his team are 14-16-0 ATS this season when he starts. May's team has been victorious in 60% of the games he's started as the moneyline favorite with a record of 9-6. The Cardinals have a 3-5-0 ATS record in Mathews' eight starts that had a set spread. The Cardinals have been the moneyline underdog in four of Mathews' starts this season, and they went 1-3 in those matchups.

Brewers vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (65.4%)

Brewers vs Cardinals Moneyline

• Milwaukee is a -164 favorite on the moneyline, while St. Louis is a +138 underdog on the road.

Brewers vs Cardinals Spread

• The Cardinals are at +1.5 on the runline against the Brewers. The Cardinals are -156 to cover the spread, and the Brewers are +130.

Brewers vs Cardinals Over/Under

• The Brewers-Cardinals contest on Sept. 26 has been given an over/under of 7.5 runs. The over is set at -115 and the under at -105.

Bet on Milwaukee Brewers vs. St. Louis Cardinals on FanDuel today!

Brewers vs Cardinals Betting Trends

• The Brewers have come away with 80 wins in the 123 contests they have been listed as the favorites in this season.
• This season Milwaukee has been victorious 28 times in 38 chances when named as a favorite of at least -164 on the moneyline.
• The Brewers and their opponents have hit the over in 70 of their 159 games with a total set by oddsmakers this season.
• The Brewers have an against the spread mark of 83-76-0 in 159 games with a line this season.
• The Cardinals have been the underdog on the moneyline 101 total times this season. They've finished 46-55 in those games.
• St. Louis has a 10-16 record (winning only 38.5% of its games) when playing as a moneyline underdog of +138 or longer.
• The Cardinals have played in 156 games with a set over/under, and have combined with opponents to go over the total 72 times (72-77-7).
• The Cardinals have put together an 83-73-0 record against the spread this season (covering 53.2% of the time).

Brewers Player Leaders

• Brice Turang leads Milwaukee with a slugging percentage of .449, fueled by 60 extra-base hits. He has a .270 batting average and an on-base percentage of .367.
• Among all qualified hitters in the majors, his batting average ranks 41st, his on-base percentage ranks 19th, and he is 46th in slugging.
• Turang has hit safely in four straight games. During his last five outings he is batting .318 with three doubles, a home run and four RBIs.
• William Contreras is hitting .270 with 27 doubles, a triple, 18 home runs and 60 walks. He's slugging .417 with an on-base percentage of .340.
• Among qualified hitters, his batting average places him 41st, his on-base percentage 54th, and his slugging percentage 77th.
• Jake Bauers leads Milwaukee with 126 hits and an OBP of .391 this season.
• Bauers brings a two-game hitting streak into this game. During his last five outings he is hitting .263 with two doubles, two walks and three RBIs.
• Jackson Chourio has 25 home runs, 72 RBI and a batting average of .286 this season.
• Chourio heads into this matchup on a three-game hitting streak. In his last five games he is batting .333 with a home run, four walks and two RBIs.

Cardinals Player Leaders

• Alec Burleson has put up a slugging percentage of .469, a team-best for the Cardinals. He's batting .280 with an on-base percentage of .344.
• Including all the qualifying hitters in the big leagues, he is 23rd in batting average, 49th in on-base percentage and 34th in slugging percentage.
• Burleson heads into this game on a three-game hitting streak. During his last five outings he is batting .158 with two home runs and four RBIs.
• Jordan Walker has 163 hits to lead his team. He has a batting average of .271 while slugging .471 with an on-base percentage of .329.
• His batting average is 40th among all qualified players, his on-base percentage ranks 70th, and he is 33rd in slugging.
• Ivan Herrera has racked up an on-base percentage of .355, a team-best for the Cardinals.
• JJ Wetherholt is batting .244 with 15 doubles, 17 home runs and 64 walks.

Brewers vs Cardinals Head to Head

• 9/25/2026: 8-4 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 7/9/2026: 8-4 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 7/8/2026: 5-1 STL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 7/7/2026: 10-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/7/2026: 4-3 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 7/6/2026: 4-3 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 5/27/2026: 2-1 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/26/2026: 6-0 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 5/25/2026: 5-1 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 5/6/2026: 6-2 MIL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!