Diamondbacks vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for May 28

Odds updated as of 3:12 p.m.

In MLB action on Wednesday, the Arizona Diamondbacks take on the Pittsburgh Pirates.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Diamondbacks vs Pirates Game Info

• Arizona Diamondbacks (27-28) vs. Pittsburgh Pirates (20-36)
• Date: Wednesday, May 28, 2025
• Time: 3:40 p.m. ET
• Venue: Chase Field -- Phoenix, Arizona
• Coverage: ARID and SportsNet PT

Diamondbacks vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: ARI: (-260) | PIT: (+215)
• Spread: ARI: -1.5 (-130) | PIT: +1.5 (+108)
• Total: 8.5 -- Over: (-115) | Under: (-105)

Diamondbacks vs Pirates Probable Starting Pitchers

Probable Pitchers: Zac Gallen (Diamondbacks) - 3-6, 5.25 ERA vs Paul Skenes (Pirates) - 3-5, 2.36 ERA

The Diamondbacks will give the nod to Zac Gallen (3-6) versus the Pirates and Paul Skenes (3-5). Gallen's team is 4-7-0 against the spread in his starts this season. Gallen's team has a record of 2-4 this season when he starts and they are the favorite on the moneyline. The Pirates have a 4-7-0 record against the spread in Skenes' starts. The Pirates were the moneyline underdog for two Skenes starts this season -- they split the games.

Diamondbacks vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Diamondbacks win (58.6%)

Diamondbacks vs Pirates Moneyline

• Arizona is the favorite, -260 on the moneyline, while Pittsburgh is a +215 underdog on the road.

Diamondbacks vs Pirates Spread

• The Pirates are at the Diamondbacks, and are +1.5 on the runline. The Pirates are -130 to cover the spread, and the Diamondbacks are +108.

Diamondbacks vs Pirates Over/Under

• A combined run total of 8.5 has been set for Diamondbacks-Pirates on May 28, with the over at -115 and the under at -105.

Bet on Arizona Diamondbacks vs. Pittsburgh Pirates on FanDuel today!

Diamondbacks vs Pirates Betting Trends

• The Diamondbacks have been favorites in 34 games this season and have come away with the win 18 times (52.9%) in those contests.
• Arizona has a record of 2-2 when favored by -260 or more this year.
• The Diamondbacks and their opponents have gone over in 24 of their 54 games with a total set by sportsbooks this season.
• The Diamondbacks are 25-29-0 against the spread in their 54 games that had a posted line this season.
• The Pirates have won 36.8% of the games this season they were the moneyline underdog (14-24).
• When playing as a moneyline underdog with odds of +215 or longer, Pittsburgh has gone 1-2 (33.3%).
• In the 54 games oddsmakers have set an over/under for the Pirates, they have combined with opponents to go over the total 21 times (21-30-3).
• The Pirates have collected a 23-31-0 record against the spread this season (covering 42.6% of the time).

Diamondbacks Player Leaders

• Geraldo Perdomo leads Arizona with an OBP of .394 this season while batting .296 with 33 walks and 27 runs scored. He has a slugging percentage of .460.
• Among the qualified batters in the majors, his batting average ranks 19th, his on-base percentage ranks 10th, and he is 46th in slugging.
• Corbin Carroll leads Arizona in total hits (59) this season while batting .259 with 31 extra-base hits. He's slugging .561 with an on-base percentage of .329.
• Among qualified hitters, he is 78th in batting average, 81st in on-base percentage and seventh in slugging percentage.
• Josh Naylor leads Arizona in slugging percentage (.451) powered by 20 extra-base hits.
• Naylor heads into this game with six games in a row with at least one hit. In his last 10 games he is hitting .237 with two doubles, a triple, a home run, a walk and seven RBIs.
• Eugenio Suarez has been key for Arizona with 45 hits, an OBP of .314 plus a slugging percentage of .508.

Pirates Player Leaders

• Oneil Cruz has put up 39 hits, a team-high for the Pirates. He's batting .231 and slugging .479 with an on-base percentage of .356.
• Including all qualified players, he ranks 128th in batting average, while his on-base percentage is 41st and he is 37th in slugging.
• Bryan Reynolds is slugging .360 to lead his team. He has a batting average of .223 with an on-base percentage of .292.
• Including all qualified players, he ranks 140th in batting average, 134th in on-base percentage and 130th in slugging percentage.
• Andrew McCutchen has accumulated a team-best .371 on-base percentage.
• Isiah Kiner-Falefa is hitting .285 with six doubles, a triple, a home run and nine walks.

Diamondbacks vs Pirates Head to Head

• 5/27/2025: 9-6 PIT (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -260, Underdog Moneyline: +215)
• 5/26/2025: 5-0 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 8/4/2024: 6-5 ARI (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 8/3/2024: 4-2 PIT (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 8/2/2024: 9-8 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 7/28/2024: 6-5 PIT (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/27/2024: 9-5 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 7/26/2024: 4-3 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 7/9/2023: 4-2 PIT (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 7/8/2023: 3-2 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)

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