Clemson vs Louisville Basketball Prediction, Odds, Picks, Best Bets for ACC Tournament

The No. 3 seed Clemson Tigers (27-5, 18-2 ACC) square off in the ACC tournament against the No. 2 seed Louisville Cardinals (26-6, 18-2 ACC) on Friday at Spectrum Center, tipping off at 9:30 p.m. ET.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Clemson vs. Louisville Game Info and Odds

• Game day: Friday, March 14, 2025
• Game time: 9:30 p.m. ET
• TV channel: ESPN
• Location: Charlotte, North Carolina
• Arena: Spectrum Center

Clemson vs. Louisville Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Clemson win (57.1%)

Before you place a wager on Clemson-Louisville contest (in which Clemson is a 1.5-point favorite and the over/under is set at 141.5 points), here are a few betting trends and insights for Friday's game.

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Clemson vs. Louisville: ATS Betting Stats and Trends

• Clemson has won 20 games against the spread this season, while failing to cover 11 times.
• Louisville is 19-13-0 ATS this season.
• When the spread is set as 1.5 or more this season, Clemson (16-9) covers a lower percentage of those games when it is the favorite (64%) than Louisville (5-1) does as the underdog (83.3%).
• The Tigers own a worse record against the spread when playing at home (10-7-0) than they do in away games (8-4-0).
• This season, the Cardinals are 8-9-0 at home against the spread (.471 winning percentage). On the road, they are 9-2-0 ATS (.818).
• Clemson is 15-5-0 against the spread in conference action this year.
• Louisville has 14 wins against the spread in 21 ACC games this season.

Clemson vs. Louisville: Moneyline Betting Stats

• Clemson has been chosen as the moneyline favorite in 24 games this year and has walked away with the win 21 times (87.5%) in those games.
• The Tigers have a win-loss record of 21-3 when favored by -120 or better by sportsbooks this year.
• Louisville has won three of the five games it was the moneyline underdog this season (60%).
• The Cardinals have a 3-2 record (winning 60% of their games) when playing as a moneyline underdog of +100 or longer.
• The moneyline set for this matchup implies Clemson has a 54.5% chance of walking away with the win.

Clemson vs. Louisville Head-to-Head Comparison

• Clemson is outscoring opponents by 11.1 points per game with a +355 scoring differential overall. It puts up 76.4 points per game (108th in college basketball) and gives up 65.3 per outing (23rd in college basketball).
• Chase Hunter's team-leading 16.2 points per game ranks 174th in the country.
• Louisville puts up 79.2 points per game (54th in college basketball) while giving up 68.7 per contest (76th in college basketball). It has a +337 scoring differential and outscores opponents by 10.5 points per game.
• Chucky Hepburn's team-leading 16.4 points per game rank him 159th in college basketball.
• The Tigers prevail in the rebound battle by an average of 2.9 boards. They are grabbing 32.3 rebounds per game (159th in college basketball) compared to their opponents' 29.4 per contest.
• Ian Schieffelin leads the team with 9.3 rebounds per game (19th in college basketball action).
• The Cardinals win the rebound battle by 4.9 boards on average. They collect 34.9 rebounds per game, 38th in college basketball, while their opponents grab 30.
• J'Vonne Hadley averages 7.3 rebounds per game (130th in college basketball) to lead the Cardinals.
• Clemson's 101.8 points per 100 possessions on offense rank 50th in college basketball, and the 87 points it allows per 100 possessions rank 33rd in college basketball.
• The Cardinals put up 101.6 points per 100 possessions (54th in college basketball), while conceding 88.1 points per 100 possessions (53rd in college basketball).

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