Astros vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for April 19

Odds updated as of 6:11 p.m.

MLB action on Saturday includes the Houston Astros taking on the San Diego Padres.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info regarding this matchup.

Astros vs Padres Game Info

• Houston Astros (9-10) vs. San Diego Padres (15-5)
• Date: Saturday, April 19, 2025
• Time: 7:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: Fox Sports 1, SCHN, and SDPA

Astros vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-162) | SD: (+136)
• Spread: HOU: -1.5 (+130) | SD: +1.5 (-156)
• Total: 9 -- Over: (-102) | Under: (-120)

Astros vs Padres Probable Starting Pitchers

Probable Pitchers: Hayden Wesneski (Astros) - 1-1, 4.00 ERA vs Michael King (Padres) - 3-0, 2.42 ERA

This contest's pitching matchup is set, as the Astros will send Hayden Wesneski (1-1) to the mound, while Michael King (3-0) will get the nod for the Padres. When Wesneski starts, his team is 2-1-0 against the spread this season. Wesneski's team won his only start as a favorite this season. The Padres have a 3-1-0 record against the spread in King's starts. The Padres were the underdog on the moneyline for one King start this season -- they won.

Astros vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (57.9%)

Astros vs Padres Moneyline

• San Diego is the underdog, +136 on the moneyline, while Houston is a -162 favorite at home.

Astros vs Padres Spread

• The Padres are at the Astros, and are +1.5 on the runline. The Padres are +130 to cover the spread, and the Astros are -156.

Astros vs Padres Over/Under

• A total of 9 runs has been set for the Astros-Padres contest on April 19, with the over available at -102 and the under at -120.

Bet on Houston Astros vs. San Diego Padres on FanDuel today!

Astros vs Padres Betting Trends

• The Astros have been favorites in 12 games this season and have come away with the win six times (50%) in those contests.
• This season Houston has come away with a win two times in four chances when named as a favorite of at least -162 on the moneyline.
• The Astros and their opponents have gone over the total this season in eight of their 19 opportunities.
• The Astros are 9-10-0 against the spread in their 19 games with a line set by sportsbooks this season.
• The Padres have gone 4-4 in games they were listed as the moneyline underdog (winning 50% of those games).
• San Diego has played as a moneyline underdog of +136 or longer in just one game this season, which it lost.
• The Padres have had an over/under set by oddsmakers 20 times, and have combined with opponents to go over the total in nine of those games (9-10-1).
• The Padres have put together a 14-6-0 record against the spread this season (covering 70% of the time).

Astros Player Leaders

• Jose Carlos Altuve leads Houston with 25 hits and an OBP of .349, plus a team-best slugging percentage of .449. He's batting .321.
• He is 15th in batting average, 57th in on-base percentage, and 64th in slugging among all qualified hitters in the majors.
• Altuve hopes to build on a three-game hitting streak in this matchup. During his last five outings he is batting .278 with a double and an RBI.
• Jeremy Pena has two doubles, three home runs and seven walks. He's batting .221 and slugging .382 with an on-base percentage of .308.
• Among all qualified hitters, he is 110th in batting average, 102nd in on-base percentage and 94th in slugging percentage.
• Pena enters this game looking to extend his nine-game hit streak. In his last 10 outings he is batting .270 with two doubles, a home run, five walks and five RBI.
• Isaac Paredes has collected 16 base hits, an OBP of .333 and a slugging percentage of .361 this season.
• Jake Meyers has been key for Houston with 16 hits, an OBP of .362 plus a slugging percentage of .365.

Padres Player Leaders

• Fernando Tatis Jr. has accumulated an on-base percentage of .424, a slugging percentage of .603, and has 25 hits, all club-bests for the Padres (while batting .342).
• He is ninth in batting average, 10th in on-base percentage and 12th in slugging percentage among all qualifying hitters in the majors.
• Tatis enters this game on a seven-game hitting streak. In his last 10 outings he is hitting .282 with five home runs, seven walks and eight RBI.
• Manny Machado is batting .307 with eight doubles, two home runs and eight walks. He's slugging .493 with an on-base percentage of .373.
• Including all qualifying players, his batting average puts him 29th, his on-base percentage is 40th, and he is 42nd in slugging.
• Luis Sangel (Reveron) Arraez has a slugging percentage of .435, a team-best for the Padres.
• Xander Bogaerts is hitting .257 with seven doubles and 10 walks.

Astros vs Padres Head to Head

• 4/18/2025: 6-4 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 9/18/2024: 4-0 SD (Favorite: Padres, Spread: -1.5, Total: 6.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/17/2024: 4-3 HOU (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/16/2024: 3-1 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/10/2023: 12-2 HOU (Favorite: Astros, Spread: -1.5, Total: 10, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 9/9/2023: 7-5 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/8/2023: 11-2 SD (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)

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