Astros vs Mariners Prediction, Odds, Moneyline, Spread & Over/Under for May 24

Odds updated as of 3:12 p.m.

Saturday's slate in the MLB includes a matchup between the Houston Astros and the Seattle Mariners.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Astros vs Mariners Game Info

• Houston Astros (26-25) vs. Seattle Mariners (29-21)
• Date: Saturday, May 24, 2025
• Time: 4:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and ROOT Sports NW

Astros vs Mariners Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-116) | SEA: (-102)
• Spread: HOU: +1.5 (-194) | SEA: -1.5 (+160)
• Total: 8.5 -- Over: (-120) | Under: (-102)

Astros vs Mariners Probable Starting Pitchers

Probable Pitchers: Framber Valdez (Astros) - 3-4, 3.57 ERA vs Bryan Woo (Mariners) - 5-1, 2.65 ERA

This contest's pitching matchup is set, as the Astros will send Framber Valdez (3-4) to the mound, while Bryan Woo (5-1) will take the ball for the Mariners. Valdez's team is 4-6-0 against the spread this season in his starts. Valdez's team has won 44.4% of his starts when they are favored on the moneyline (4-5). The Mariners are 5-4-0 against the spread when Woo starts. The Mariners are 3-2 in Woo's five starts this season that they were the underdog on the moneyline.

Astros vs Mariners Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (54%)

Astros vs Mariners Moneyline

• Seattle is a -102 underdog on the moneyline, while Houston is a -116 favorite at home.

Astros vs Mariners Spread

• The Mariners are 1.5-run favorites against the spread for this matchup with the Astros. The Mariners are +160 to cover, while the Astros are -194 to cover as a 1.5-run underdog on the runline.

Astros vs Mariners Over/Under

• Astros versus Mariners, on May 24, has an over/under of 8.5, with the over being -120 and the under -102.

Bet on Houston Astros vs. Seattle Mariners on FanDuel today!

Astros vs Mariners Betting Trends

• The Astros have won in 18, or 52.9%, of the 34 contests they have been named as odds-on favorites in this year.
• This year Houston has won 17 of 32 games when listed as at least -116 on the moneyline.
• The Astros and their opponents have gone over in 21 of their 51 games with a total set by sportsbooks this season.
• The Astros have an against the spread mark of 27-24-0 in 51 games with a line this season.
• The Mariners have compiled a 12-8 record in games they were the underdog on the moneyline (winning 60% of those games).
• Seattle has an 11-6 record (winning 64.7% of its games) when it has played as a moneyline underdog of -102 or longer.
• The Mariners have combined with opponents to hit the over on the total 27 times this season for a 27-20-2 record against the over/under.
• The Mariners have a 25-24-0 record ATS this season.

Astros Player Leaders

• Isaac Paredes leads Houston in OBP (.374) and total hits (50) this season. He's batting .267 batting average while slugging .487.
• Among qualifying hitters in the majors, he ranks 67th in batting average, 28th in on-base percentage, and 36th in slugging.
• Jeremy Pena has an OPS of .796, fueled by an OBP of .358 and a team-best slugging percentage of .438 this season. He's batting .292.
• His batting average ranks 26th among qualified players, his on-base percentage 45th, and his slugging percentage 65th.
• Jake Meyers is batting .309 with a .428 slugging percentage and 16 RBI this year.
• Meyers has recorded a hit in eight games in a row. In his last 10 outings he is batting .314 with a double, a home run, three walks and two RBIs.
• Jose Altuve is batting .253 with a .303 OBP and 18 RBI for Houston this season.
• Altuve brings a two-game hitting streak into this game. During his last five outings he is hitting .350 with two home runs, a walk and four RBIs.

Mariners Player Leaders

• Cal Raleigh has 47 hits with a .593 slugging percentage, both team-best numbers for the Mariners. He's batting .258 and with an on-base percentage of .373.
• Including all qualifying hitters in the big leagues, he ranks 81st in batting average, 30th in on-base percentage and fourth in slugging percentage.
• Raleigh brings a four-game hitting streak into this game. In his last five games he is batting .350 with two doubles, two home runs, two walks and three RBIs.
• Julio Rodriguez is batting .230 with six doubles, two triples, nine home runs and 18 walks. He's slugging .415 with an on-base percentage of .306.
• His batting average ranks 124th among all qualified players, his on-base percentage ranks 117th, and he is 82nd in slugging.
• Jorge Polanco is batting .285 with six doubles, 10 home runs and nine walks.
• J.P. Crawford's .386 on-base percentage leads his team.

Astros vs Mariners Head to Head

• 5/23/2025: 5-3 SEA (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/22/2025: 9-2 HOU (Favorite: Mariners, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 4/9/2025: 7-6 SEA (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/8/2025: 2-1 HOU (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 4/7/2025: 4-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 9/25/2024: 8-1 SEA (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/24/2024: 4-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/23/2024: 6-1 SEA (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/21/2024: 6-4 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/20/2024: 4-2 HOU (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)

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