Astros vs Mariners Prediction, Odds, Moneyline, Spread & Over/Under for May 24

Odds updated as of 10:14 p.m.

The Houston Astros are among the MLB squads in action on Saturday, up against the Seattle Mariners.

All the information you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Astros vs Mariners Game Info

• Houston Astros (26-24) vs. Seattle Mariners (28-21)
• Date: Saturday, May 24, 2025
• Time: 4:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and ROOT Sports NW

Astros vs Mariners Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-116) | SEA: (-102)
• Spread: HOU: +1.5 (-194) | SEA: -1.5 (+160)
• Total: 8.5 -- Over: (-120) | Under: (-102)

Astros vs Mariners Probable Starting Pitchers

Probable Pitchers: Framber Valdez (Astros) - 3-4, 3.57 ERA vs Bryan Woo (Mariners) - 5-1, 2.65 ERA

This contest's pitching matchup is set, as the Astros will send Framber Valdez (3-4) to the mound, while Bryan Woo (5-1) will get the nod for the Mariners. Valdez's team is 4-6-0 against the spread in his starts this season. Valdez's team has won 44.4% of his starts when they are favored on the moneyline (4-5). The Mariners have gone 5-4-0 against the spread when Woo starts. The Mariners have been the moneyline underdog in five of Woo's starts this season, and they went 3-2 in those games.

Astros vs Mariners Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (54.1%)

Astros vs Mariners Moneyline

• Looking at the moneyline for Astros-Mariners, Houston is the favorite at -116, and Seattle is -102 playing on the road.

Astros vs Mariners Spread

• The Mariners are 1.5-run favorites against the spread for this matchup with the Astros. The Mariners are +160 to cover, while the Astros are -194 to cover as a 1.5-run underdog on the runline.

Astros vs Mariners Over/Under

• The over/under for Astros-Mariners on May 24 is 8.5. The over is -120, and the under is -102.

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Astros vs Mariners Betting Trends

• The Astros have been favorites in 33 games this season and have come away with the win 18 times (54.5%) in those contests.
• Houston has a record of 17-14 when favored by -116 or more this year.
• The Astros and their opponents have gone over the total this season in 21 of their 50 opportunities.
• The Astros are 27-23-0 against the spread in their 50 games that had a posted line this season.
• The Mariners have been the underdog on the moneyline 19 total times this season. They've finished 11-8 in those games.
• Seattle has an 11-6 record (winning 64.7% of its games) when it has played as a moneyline underdog of -102 or longer.
• The Mariners have combined with opponents to hit the over on the total 27 times this season for a 27-19-2 record against the over/under.
• The Mariners have a 24-24-0 record against the spread this season (covering 50% of the time).

Astros Player Leaders

• Isaac Paredes leads Houston with 48 hits and an OBP of .374 this season. He has a .264 batting average and a slugging percentage of .473.
• Among all qualified batters in MLB, he ranks 66th in batting average, 28th in on-base percentage, and 44th in slugging.
• Jeremy Pena leads Houston in slugging percentage (.447) thanks to 15 extra-base hits. He's batting .298 with an on-base percentage of .362.
• Among qualified hitters, his batting average places him 23rd, his on-base percentage 40th, and his slugging percentage 60th.
• Jake Meyers has 45 hits this season and has a slash line of .304/.366/.426.
• Meyers takes a seven-game hitting streak into this game. During his last 10 games he is batting .324 with a double, a home run, three walks and two RBIs.
• Jose Altuve has been key for Houston with 46 hits, an OBP of .296 plus a slugging percentage of .370.

Mariners Player Leaders

• Cal Raleigh has 45 hits with a .579 slugging percentage, both team-best numbers for the Mariners. He's batting .253 and with an on-base percentage of .371.
• Including all qualified hitters, he is 85th in batting average, while his on-base percentage is 31st and he is fifth in slugging.
• Raleigh hopes to build on a three-game hitting streak in this matchup. During his last five outings he is hitting .250 with two doubles, a home run, two walks and two RBIs.
• Julio Rodriguez's .415 slugging percentage leads his team. He has a batting average of .231 with an on-base percentage of .309.
• Including all qualifying hitters, he is 120th in batting average, 111th in on-base percentage and 80th in slugging percentage.
• Jorge Polanco is batting .291 with six doubles, 10 home runs and nine walks.
• J.P. Crawford's .386 on-base percentage paces his team.

Astros vs Mariners Head to Head

• 5/22/2025: 9-2 HOU (Favorite: Mariners, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 4/9/2025: 7-6 SEA (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/8/2025: 2-1 HOU (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 4/7/2025: 4-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 9/25/2024: 8-1 SEA (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/24/2024: 4-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/23/2024: 6-1 SEA (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/21/2024: 6-4 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/20/2024: 4-2 HOU (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/19/2024: 3-0 HOU (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -110, Underdog Moneyline: -106)

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