Astros vs Mariners Prediction, Odds, Moneyline, Spread & Over/Under for May 23

Odds updated as of 8:16 p.m.

On Friday in MLB, the Houston Astros are playing the Seattle Mariners.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Astros vs Mariners Game Info

• Houston Astros (26-24) vs. Seattle Mariners (28-21)
• Date: Friday, May 23, 2025
• Time: 8:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and ROOT Sports NW

Astros vs Mariners Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-126) | SEA: (+108)
• Spread: HOU: -1.5 (+184) | SEA: +1.5 (-225)
• Total: 7.5 -- Over: (-100) | Under: (-122)

Astros vs Mariners Probable Starting Pitchers

Probable Pitchers: Ryan Gusto (Astros) - 3-2, 4.65 ERA vs Emerson Hancock (Mariners) - 1-2, 6.21 ERA

The Astros will look to Ryan Gusto (3-2) against the Mariners and Emerson Hancock (1-2). When Gusto starts, his team is 3-2-0 against the spread this season. Gusto's team has a record of 3-2 this season when he starts and they are the favorite on the moneyline. The Mariners have a 5-2-0 ATS record in Hancock's seven starts with a set spread. The Mariners have a 4-1 record in Hancock's five starts this season when they were the moneyline underdog.

Astros vs Mariners Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (54.1%)

Astros vs Mariners Moneyline

• Looking at the moneyline for Mariners-Astros, Seattle is the underdog at +108, and Houston is -126 playing at home.

Astros vs Mariners Spread

• The Astros are hosting the Mariners and are favored by 1.5 runs on the spread. The Astros are +184 to cover the runline, with the Mariners being -225.

Astros vs Mariners Over/Under

• The over/under for the Astros versus Mariners contest on May 23 has been set at 7.5, with -100 odds on the over and -122 odds on the under.

Bet on Houston Astros vs. Seattle Mariners on FanDuel today!

Astros vs Mariners Betting Trends

• The Astros have been victorious in 18, or 54.5%, of the 33 contests they have been chosen as favorites in this season.
• Houston has a record of 12-10 in contests when bookmakers favor them by -126 or more on the moneyline.
• The Astros and their opponents have gone over in 21 of their 50 games with a total set by sportsbooks this season.
• In 50 games with a line this season, the Astros have a mark of 27-23-0 against the spread.
• The Mariners have won 11 of the 19 games they were listed as the moneyline underdog this season (57.9%).
• When playing as a moneyline underdog with odds of +108 or longer, Seattle has gone 8-3 (72.7%).
• The Mariners have played in 48 games with a set over/under, and have combined with opponents to go over the total 27 times (27-19-2).
• The Mariners have put together a 24-24-0 record ATS this season (covering 50% of the time).

Astros Player Leaders

• Isaac Paredes has 48 hits and an OBP of .374, both of which rank first among Houston hitters this season. He has a .264 batting average and a slugging percentage of .473.
• Among all qualifying batters, he ranks 65th in batting average, his on-base percentage ranks 25th, and he is 45th in slugging.
• Jeremy Pena leads Houston in slugging percentage (.447) thanks to 15 extra-base hits. He's batting .298 with an on-base percentage of .362.
• Among all qualified, he is 23rd in batting average, 40th in on-base percentage and 59th in slugging percentage.
• Jake Meyers has collected 45 base hits, an OBP of .366 and a slugging percentage of .426 this season.
• Meyers enters this game with seven games in a row with at least one hit. During his last 10 outings he is hitting .324 with a double, a home run, three walks and two RBIs.
• Jose Altuve has six home runs, 18 RBI and a batting average of .243 this season.

Mariners Player Leaders

• Cal Raleigh has racked up 45 hits with a .579 slugging percentage, both team-high numbers for the Mariners. He's batting .253 and with an on-base percentage of .371.
• Including all the qualified hitters in MLB, his batting average ranks 85th, his on-base percentage is 32nd, and he is fifth in slugging.
• Raleigh heads into this matchup on a three-game hitting streak. In his last five games he is hitting .250 with two doubles, a home run, two walks and two RBIs.
• Julio Rodriguez is slugging .415 to pace his team. He has a batting average of .231 with an on-base percentage of .309.
• Including all qualifying players, he is 118th in batting average, 109th in on-base percentage and 83rd in slugging percentage.
• Jorge Polanco is batting .291 with six doubles, 10 home runs and nine walks.
• J.P. Crawford has a .386 on-base percentage to lead his team.

Astros vs Mariners Head to Head

• 5/22/2025: 9-2 HOU (Favorite: Mariners, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 4/9/2025: 7-6 SEA (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/8/2025: 2-1 HOU (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 4/7/2025: 4-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 9/25/2024: 8-1 SEA (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/24/2024: 4-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/23/2024: 6-1 SEA (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/21/2024: 6-4 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/20/2024: 4-2 HOU (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/19/2024: 3-0 HOU (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -110, Underdog Moneyline: -106)

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