Astros vs Mariners Prediction, Odds, Moneyline, Spread & Over/Under for May 23

Odds updated as of 8:12 a.m.

Friday's slate in the MLB includes a matchup between the Houston Astros and the Seattle Mariners.

We've got you covered, in terms of the most important information about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Astros vs Mariners Game Info

• Houston Astros (26-24) vs. Seattle Mariners (28-21)
• Date: Friday, May 23, 2025
• Time: 8:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and ROOT Sports NW

Astros vs Mariners Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-126) | SEA: (+108)
• Spread: HOU: -1.5 (+152) | SEA: +1.5 (-184)
• Total: 8.5 -- Over: (-114) | Under: (-106)

Astros vs Mariners Probable Starting Pitchers

Probable Pitchers: Ryan Gusto (Astros) - 3-2, 4.65 ERA vs Emerson Hancock (Mariners) - 1-2, 6.21 ERA

The probable starters are Ryan Gusto (3-2) for the Astros and Emerson Hancock (1-2) for the Mariners. When Gusto starts, his team is 3-2-0 against the spread this season. Gusto's team is 3-2 this season when he starts and they are the moneyline favorite. The Mariners have a 5-2-0 record against the spread in Hancock's starts. The Mariners have a 4-1 record in Hancock's five starts this season when they were the underdog on the moneyline.

Astros vs Mariners Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (53%)

Astros vs Mariners Moneyline

• Seattle is a +108 underdog on the moneyline, while Houston is a -126 favorite at home.

Astros vs Mariners Spread

• The Astros are hosting the Mariners and are favored by 1.5 runs (+152 to cover) on the runline. Seattle is -184 to cover.

Astros vs Mariners Over/Under

• The over/under for Astros-Mariners on May 23 is 8.5. The over is -114, and the under is -106.

Bet on Houston Astros vs. Seattle Mariners on FanDuel today!

Astros vs Mariners Betting Trends

• The Astros have been victorious in 18, or 54.5%, of the 33 contests they have been chosen as favorites in this season.
• This season Houston has been victorious 12 times in 22 chances when named as a favorite of at least -126 on the moneyline.
• Contests with the Astros have gone over the total set by bookmakers in 21 of 50 chances this season.
• The Astros have an against the spread record of 27-23-0 in 50 games with a line this season.
• The Mariners have an 11-8 record in games they were listed as the moneyline underdog (winning 57.9% of those games).
• When it has played as a moneyline underdog with odds of +108 or longer, Seattle has gone 8-3 (72.7%).
• In the 48 games oddsmakers have set an over/under for the Mariners, they have combined with opponents to go over the total 27 times (27-19-2).
• The Mariners have covered 50% of their games this season, going 24-24-0 ATS.

Astros Player Leaders

• Isaac Paredes has 48 hits and an OBP of .374, both of which rank first among Houston hitters this season. He has a .264 batting average and a slugging percentage of .473.
• Among qualified hitters in the majors, his batting average ranks 65th, his on-base percentage ranks 25th, and he is 45th in slugging.
• Jeremy Pena leads Houston in slugging percentage (.447) thanks to 15 extra-base hits. He's batting .298 with an on-base percentage of .362.
• Among qualified batters, his batting average places him 21st, his on-base percentage 40th, and his slugging percentage 59th.
• Jake Meyers is batting .304 with a .426 slugging percentage and 16 RBI this year.
• Meyers brings a seven-game hitting streak into this game. During his last 10 games he is batting .324 with a double, a home run, three walks and two RBIs.
• Jose Altuve has been key for Houston with 46 hits, an OBP of .296 plus a slugging percentage of .370.

Mariners Player Leaders

• Cal Raleigh has a team-high slugging percentage (.579) while pacing the Mariners in hits (45). He's batting .253 and with an on-base percentage of .371.
• Including all qualified hitters in the big leagues, he is 85th in batting average, 32nd in on-base percentage and fifth in slugging percentage.
• Raleigh hopes to build on a three-game hitting streak in this matchup. In his last five games he is batting .250 with two doubles, a home run, two walks and two RBIs.
• Julio Rodriguez's .415 slugging percentage leads his team. He has a batting average of .231 with an on-base percentage of .309.
• Including all qualifying hitters, his batting average places him 118th, his on-base percentage ranks 108th, and he is 82nd in slugging.
• Jorge Polanco is hitting .291 with six doubles, 10 home runs and nine walks.
• J.P. Crawford paces his team with a .386 on-base percentage.

Astros vs Mariners Head to Head

• 5/22/2025: 9-2 HOU (Favorite: Mariners, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 4/9/2025: 7-6 SEA (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/8/2025: 2-1 HOU (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 4/7/2025: 4-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 9/25/2024: 8-1 SEA (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/24/2024: 4-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/23/2024: 6-1 SEA (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/21/2024: 6-4 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/20/2024: 4-2 HOU (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/19/2024: 3-0 HOU (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -110, Underdog Moneyline: -106)

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