Astros vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 26

Odds updated as of 9:11 p.m.

The MLB schedule on Saturday includes the Houston Astros facing the Athletics.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Astros vs Athletics Game Info

• Houston Astros (79-81) vs. Athletics (64-96)
• Date: Saturday, September 26, 2026
• Time: 9:40 p.m. ET
• Venue: Sutter Health Park -- West Sacramento, California
• Coverage: NBCS-CA and SCHN

Astros vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-158) | OAK: (+134)
• Spread: HOU: -1.5 (-104) | OAK: +1.5 (-115)
• Total: 9.5 -- Over: (-120) | Under: (-102)

Astros vs Athletics Probable Starting Pitchers

Probable Pitchers: Hayden Wesneski (Astros) - 5-2, 3.50 ERA vs Jack Perkins (Athletics) - 3-12, 5.90 ERA

The Astros will give the nod to Hayden Wesneski (5-2, 3.50 ERA), who is eyeing win No. 6 on the season, and the Athletics will turn to Jack Perkins (3-12, 5.90 ERA). Wesneski's team is 7-3-0 against the spread this season in his starts. Wesneski's team has a record of 5-2 this season when he starts and they are the favorite on the moneyline. The Athletics have gone 4-11-0 ATS in Perkins' 15 starts with a set spread. The Athletics have a 1-9 record in Perkins' 10 starts this season when they were the moneyline underdog.

Astros vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (50.9%)

Astros vs Athletics Moneyline

• The Astros vs Athletics moneyline has the Astros as a -158 favorite, while the Athletics are a +134 underdog at home.

Astros vs Athletics Spread

• The Astros are 1.5-run favorites on the runline against the Athletics. The Astros are -104 to cover, while the Athletics are -115 to cover.

Astros vs Athletics Over/Under

• Astros versus Athletics, on Sept. 26, has an over/under of 9.5, with the over being -120 and the under -102.

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Astros vs Athletics Betting Trends

• The Astros have won in 36, or 51.4%, of the 70 contests they have been named as odds-on favorites in this year.
• This season, the Astros have come away with a win eight times in 21 chances when named as a favorite of at least -158 or shorter on the moneyline.
• The Astros and their opponents have hit the over in 79 of their 160 games with a total this season.
• The Astros have an against the spread record of 80-80-0 in 160 games with a line this season.
• The Athletics have been the moneyline underdog 121 total times this season. They've gone 47-74 in those games.
• In games they have played as a moneyline underdog with odds of +134 or longer, the Athletics have a record of 19-36 (34.5%).
• The Athletics have played in 159 games with an over/under set, and have combined with their opponents to go over the total 84 times (84-73-2).
• The Athletics have put together a 76-83-0 record ATS this season (covering 47.8% of the time).

Astros Player Leaders

• Yordan Alvarez leads Houston in OBP (.433), slugging percentage (.599) and total hits (176) this season. He has a .315 batting average.
• Among all qualified batters in baseball, his batting average ranks first, his on-base percentage ranks first, and he is first in slugging.
• Alvarez hopes to build on a 10-game hitting streak in this matchup. In his last 10 games he is hitting .400 with three doubles, three home runs, eight walks and six RBIs.
• Isaac Paredes is hitting .260 with 27 doubles, a triple, 24 home runs and 70 walks. He's slugging .442 with an on-base percentage of .358.
• His batting average ranks 61st among qualified players, his on-base percentage 33rd, and his slugging percentage 51st.
• Christian Walker has 126 hits this season and has a slash line of .223/.296/.420.
• Walker takes a four-game hitting streak into this game. During his last five outings he is hitting .263 with three home runs, two walks and five RBIs.
• Jose Altuve has 16 home runs, 47 RBI and a batting average of .249 this season.

Athletics Player Leaders

• Jeff McNeil has put up a slugging percentage of .373, a team-best for the Athletics. He's batting .267 with an on-base percentage of .315.
• Including all qualified hitters in the big leagues, his batting average puts him 46th, his on-base percentage ranks 97th, and he is 115th in slugging.
• McNeil takes a three-game hitting streak into this game. During his last five outings he is hitting .333 with a double, a home run, two walks and five RBIs.
• Zack Gelof is batting .256 with 16 doubles, two triples, 22 home runs and 31 walks. He's slugging .479 with an on-base percentage of .323.
• Shea Langeliers has 21 doubles, 23 home runs and 36 walks while batting .263.
• Lawrence Butler's 110 hits and .326 on-base percentage both pace his team.

Astros vs Athletics Head to Head

• 9/25/2026: 6-5 OAK (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -186, Underdog Moneyline: +156)
• 9/24/2026: 7-5 HOU (Favorite: Astros, Spread: -1.5, Total: 10.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 8/23/2026: 7-6 OAK (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +162)
• 8/22/2026: 4-3 OAK (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -235, Underdog Moneyline: +215)
• 8/21/2026: 4-0 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +162)
• 6/7/2026: 5-0 OAK (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 6/6/2026: 13-2 HOU (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/5/2026: 5-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 4/5/2026: 12-10 OAK (Favorite: Astros, Spread: -1.5, Total: 10, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 4/4/2026: 11-0 HOU (Favorite: Athletics, Spread: -1.5, Total: 9.5, Favorite Moneyline: -108, Underdog Moneyline: -108)

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