Padres vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 26

Odds updated as of 8:11 p.m.

The Saturday schedule in MLB includes a matchup between the San Diego Padres and the Arizona Diamondbacks.

We've got you covered, in terms of the vital info about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Padres vs Diamondbacks Game Info

• San Diego Padres (89-71) vs. Arizona Diamondbacks (86-74)
• Date: Saturday, September 26, 2026
• Time: 8:40 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: Padres.TV and Dbacks.TV

Padres vs Diamondbacks Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-120) | ARI: (+102)
• Spread: SD: +1.5 (-205) | ARI: -1.5 (+172)
• Total: 7.5 -- Over: (-118) | Under: (-104)

Padres vs Diamondbacks Probable Starting Pitchers

Probable Pitchers: Walker Buehler (Padres) - 9-6, 4.56 ERA vs Taylor Clarke (Diamondbacks) - 2-4, 2.86 ERA

The Padres will call on Walker Buehler (9-6) versus the Diamondbacks and Taylor Clarke (2-4). Buehler's team is 23-8-0 against the spread this season in his starts. Buehler's team has been victorious in 69.2% of the games he's started as the moneyline favorite with a record of 9-4. Clarke has started only one game with a set spread, which the Diamondbacks covered. The Diamondbacks were the underdog on the moneyline for one Clarke start this season -- they won.

Padres vs Diamondbacks Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (54.6%)

Padres vs Diamondbacks Moneyline

• Arizona is the underdog, +102 on the moneyline, while San Diego is a -120 favorite at home.

Padres vs Diamondbacks Spread

• The Diamondbacks are 1.5-run favorites against the spread for this matchup with the Padres. The Diamondbacks are +172 to cover, while the Padres are -205 to cover as a 1.5-run underdog on the runline.

Padres vs Diamondbacks Over/Under

• The Padres-Diamondbacks game on Sept. 26 has been given an over/under of 7.5 runs. The over is set at -118 and the under at -104.

Bet on San Diego Padres vs. Arizona Diamondbacks on FanDuel today!

Padres vs Diamondbacks Betting Trends

• The Padres have been chosen as favorites in 79 games this year and have walked away with the win 48 times (60.8%) in those games.
• San Diego has a record of 38-24 in contests when oddsmakers favor them by -120 or more on the moneyline.
• The Padres and their opponents have gone over in 75 of their 160 games with a total set by sportsbooks this season.
• The Padres are 92-68-0 against the spread in their 160 games with a line set by sportsbooks this season.
• The Diamondbacks have won 40 of the 83 games they were listed as the moneyline underdog this season (48.2%).
• When playing as a moneyline underdog with odds of +102 or longer, Arizona has a 32-35 record (winning 47.8% of its games).
• In the 158 games bookmakers have set an over/under for the Diamondbacks, they have combined with opponents to go over the total 69 times (69-85-4).
• The Diamondbacks are 84-74-0 ATS this season.

Padres Player Leaders

• Fernando Tatis Jr. leads San Diego in OBP (.360), slugging percentage (.473) and total hits (181) this season. He has a .291 batting average.
• Among all qualified hitters in the majors, he is 10th in batting average, 30th in on-base percentage, and 31st in slugging.
• Tatis has recorded a base hit in eight straight games. In his last 10 outings he is batting .325 with three doubles, three home runs, three walks and five RBIs.
• Jackson Merrill is hitting .253 with 26 doubles, five triples, 26 home runs and 40 walks. He's slugging .440 with an on-base percentage of .301.
• He ranks 72nd in batting average, 116th in on-base percentage and 54th in slugging in the majors.
• Merrill takes a two-game streak with at least one hit into this one. During his last five outings he is batting .167 with a double.
• Manny Machado has collected 125 base hits, an OBP of .302 and a slugging percentage of .402 this season.
• Xander Bogaerts has 12 home runs, 56 RBI and a batting average of .230 this season.

Diamondbacks Player Leaders

• Corbin Carroll has 32 doubles, 17 triples, 22 home runs and 73 walks while hitting .239. He's slugging .469 with an on-base percentage of .329.
• Including all qualifying players, he is 97th in batting average, while his on-base percentage ranks 70th and he is 34th in slugging.
• Geraldo Perdomo's .379 slugging percentage leads his team. He has a batting average of .263 with an on-base percentage of .369.
• Including all qualified hitters, his batting average puts him 54th, his on-base percentage is 15th, and he is 109th in slugging.
• Gabriel Moreno has racked up 146 hits with a .387 on-base percentage and a .487 slugging percentage, all club-bests for the Diamondbacks.
• Ketel Marte is hitting .248 with 30 doubles, three triples, 22 home runs and 51 walks.

Padres vs Diamondbacks Head to Head

• 9/25/2026: 11-4 ARI (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/6/2026: 5-1 SD (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -104, Underdog Moneyline: -104)
• 8/5/2026: 10-4 ARI (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +122)
• 8/4/2026: 9-4 SD (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -114, Underdog Moneyline: +104)
• 8/3/2026: 5-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: +100)
• 7/9/2026: 3-1 ARI (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/8/2026: 10-4 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/7/2026: 4-1 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/6/2026: 8-0 ARI (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/26/2026: 12-7 ARI (Favorite: Padres, Spread: -1.5, Total: 15, Favorite Moneyline: -134, Underdog Moneyline: +114)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!