Astros vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for May 28

Odds updated as of 1:14 p.m.

The Houston Astros versus the Athletics is on the MLB schedule for Wednesday.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Astros vs Athletics Game Info

• Houston Astros (29-25) vs. Athletics (23-32)
• Date: Wednesday, May 28, 2025
• Time: 2:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and NBCS-CA

Astros vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-240) | OAK: (+198)
• Spread: HOU: -1.5 (-110) | OAK: +1.5 (-110)
• Total: 8 -- Over: (-114) | Under: (-106)

Astros vs Athletics Probable Starting Pitchers

Probable Pitchers: Lance McCullers (Astros) - 0-1, 6.57 ERA vs Luis Severino (Athletics) - 1-4, 4.11 ERA

The probable starters are Lance McCullers (0-1) for the Astros and Luis Severino (1-4) for the Athletics. McCullers' team is 2-2-0 against the spread this season in his starts. McCullers' team is 0-2 this season when he starts and they're favored on the moneyline. The Athletics have a 5-6-0 ATS record in Severino's 11 starts with a set spread. The Athletics have a 3-6 record in Severino's nine starts this season when they were the underdog on the moneyline.

Astros vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (55.8%)

Astros vs Athletics Moneyline

• The Astros vs Athletics moneyline has the Astros as a -240 favorite, while the Athletics are a +198 underdog on the road.

Astros vs Athletics Spread

• The Astros are 1.5-run favorites on the runline against the Athletics. The Astros are -110 to cover, while the Athletics are -110 to cover.

Astros vs Athletics Over/Under

• Astros versus Athletics, on May 28, has an over/under of 8, with the over being -114 and the under -106.

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Astros vs Athletics Betting Trends

• The Astros have been victorious in 19, or 54.3%, of the 35 contests they have been chosen as favorites in this season.
• The Astros have been listed as a favorite of -240 or more on two occasions this season and split those games.
• The Astros and their opponents have hit the over in 22 of their 54 games with a total this season.
• The Astros have posted a record of 30-24-0 against the spread this season.
• The Athletics have won 12 of the 35 games they were the moneyline underdog this season (34.3%).
• The Athletics have played as a moneyline underdog of +198 or longer in only two games this season, which they lost both.
• The Athletics have played in 55 games with an over/under set, and have combined with their opponents to go over the total 30 times (30-22-3).
• The Athletics have put together a 26-29-0 record against the spread this season (covering 47.3% of the time).

Astros Player Leaders

• Isaac Paredes has 54 hits and an OBP of .371, both of which are tops among Houston hitters this season. He has a .270 batting average and a slugging percentage of .480.
• Among qualified hitters in baseball, his batting average ranks 58th, his on-base percentage ranks 29th, and he is 36th in slugging.
• Jeremy Pena has an OPS of .811, fueled by an OBP of .362 and a team-best slugging percentage of .449 this season. He's batting .298.
• His batting average ranks 18th among qualified players, his on-base percentage 37th, and his slugging percentage 59th.
• Pena heads into this game looking to extend his three-game hit streak. During his last five outings he is batting .300 with a triple, a home run, a walk and four RBIs.
• Jose Altuve has 56 hits this season and has a slash line of .272/.321/.417.
• Altuve has logged a hit or more in five games in a row. During his last five outings he is hitting .571 with four home runs, a walk and seven RBIs.
• Jake Meyers is batting .299 with a .356 OBP and 16 RBI for Houston this season.

Athletics Player Leaders

• Jacob Wilson has an on-base percentage of .390, a slugging percentage of .490, and has 71 hits, all club-bests for the Athletics (while batting .348).
• Including all the qualifying hitters in the big leagues, he is third in batting average, 11th in on-base percentage and 32nd in slugging percentage.
• Wilson enters this game on a three-game hitting streak. In his last five games he is batting .409 with a double, a home run, two walks and two RBIs.
• Brent Rooker is batting .250 with eight doubles, a triple, 12 home runs and 20 walks. He's slugging .459 with an on-base percentage of .318.
• Including all qualified hitters, his batting average puts him 94th, his on-base percentage is 103rd, and he is 47th in slugging.
• Tyler Soderstrom has 10 doubles, 10 home runs and 20 walks while hitting .264.
• Lawrence Butler is hitting .252 with 15 doubles, a triple, eight home runs and 17 walks.

Astros vs Athletics Head to Head

• 5/27/2025: 11-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -240, Underdog Moneyline: +198)
• 9/12/2024: 6-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -260, Underdog Moneyline: +215)
• 9/11/2024: 5-4 OAK (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 9/10/2024: 4-3 OAK (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 7/24/2024: 8-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 7/23/2024: 8-2 OAK (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/22/2024: 4-0 OAK (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 5/26/2024: 5-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/25/2024: 3-1 OAK (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 5/24/2024: 6-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -176, Underdog Moneyline: +148)

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