The NCAA Tournament is already taking shape, and with several first-round games complete, we now have a clearer picture of the path to the Sweet 16. If you're looking for March Madness predictions, Sweet 16 picks, and best bets today, the key edge comes from focusing on confirmed Round of 32 matchups — where we can properly evaluate form, matchups, and momentum. Here are the best bets and predictions for teams most likely to reach the Sweet 16 based on games already set. East Region Sweet 16 Predictions Duke (1) vs. TCU (9) Duke survived an early scare against Siena, while TCU edged Ohio State in a close game. This matchup favors Duke’s overall talent and depth. Why Duke advances: Superior shot creation Depth advantage Higher offensive ceiling Pick: Duke to reach Sweet 16 Louisville (6) vs. Michigan State (3) Louisville knocked off South Florida, but Michigan State looked dominant in its first-round win. Why Michigan State advances: Physical defense More consistent offensive structure Tournament experience Pick: Michigan State to reach Sweet 16 West Region Sweet 16 Predictions High Point (12) vs

Find Rockets vs. Hawks predictions, betting odds, moneyline, spread, over/under and more for the March 20 NBA matchup.