Yankees vs Twins Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 16

Odds updated as of 1:13 p.m.

In MLB action on Wednesday, the New York Yankees face the Minnesota Twins.

We've got you covered, in terms of the most important information about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Yankees vs Twins Game Info

• New York Yankees (88-63) vs. Minnesota Twins (70-81)
• Date: Wednesday, September 16, 2026
• Time: 1:40 p.m. ET
• Venue: Target Field -- Minneapolis, Minnesota
• Coverage: Twins.TV and YES

Yankees vs Twins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYY: (-152) | MIN: (+128)
• Spread: NYY: -1.5 (+108) | MIN: +1.5 (-130)
• Total: 7.5 -- Over: (-134) | Under: (+110)

Yankees vs Twins Probable Starting Pitchers

Probable Pitchers: Carlos Rodon (Yankees) - 6-3, 2.94 ERA vs Zebby Matthews (Twins) - 9-10, 4.98 ERA

The Yankees will give the nod to Carlos Rodon (6-3, 2.94 ERA), who is eyeing win No. 7 on the season, and the Twins will counter with Zebby Matthews (9-10, 4.98 ERA). Rodon's team is 7-7-0 against the spread in his starts this season. Rodon's team is 7-3 this season when he starts and they are the moneyline favorite. When Matthews starts, the Twins have gone 12-8-0 against the spread. The Twins have a 6-5 record in Matthews' 11 starts this season when they were the moneyline underdog.

Yankees vs Twins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Yankees win (58.2%)

Yankees vs Twins Moneyline

• Minnesota is the underdog, +128 on the moneyline, while New York is a -152 favorite despite being on the road.

Yankees vs Twins Spread

• The Yankees are at the Twins and are favored by 1.5 runs on the spread. The Yankees are +108 to cover the runline, with the Twins being -130.

Yankees vs Twins Over/Under

• A combined run total of 7.5 has been set for Yankees-Twins on Sept. 16, with the over at -134 and the under at +110.

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Yankees vs Twins Betting Trends

• The Yankees have been chosen as favorites in 117 games this year and have walked away with the win 71 times (60.7%) in those games.
• This year New York has won 35 of 52 games when listed as at least -152 on the moneyline.
• The Yankees' games have gone over the total in 66 of their 146 opportunities.
• The Yankees are 76-70-0 against the spread in their 146 games that had a posted line this season.
• The Twins have been the moneyline underdog 89 total times this season. They've gone 38-51 in those games.
• Minnesota is 12-16 (winning 42.9% of its games) when it has played as a moneyline underdog of +128 or longer.
• The Twins have combined with opponents to go over the total 83 times this season for an 83-61-3 record against the over/under.
• The Twins are 78-69-0 against the spread this season.

Yankees Player Leaders

• Ben Rice leads New York OPS (.882) this season. He has a .262 batting average, an on-base percentage of .357, and a slugging percentage of .525.
• Among all qualified batters in the majors, his batting average ranks 62nd, his on-base percentage ranks 35th, and he is sixth in slugging.
• Rice hopes to build on a five-game hitting streak in this matchup. During his last five outings he is hitting .400 with two home runs, three walks and four RBIs.
• Luis Garcia has 140 hits, which is best among New York batters this season. He's batting .286 with 61 extra-base hits. He's also slugging .543 with an on-base percentage of .317.
• He ranks 15th in batting average, 91st in on-base percentage and third in slugging among qualified hitters.
• Cody Bellinger is batting .272 with a .443 slugging percentage and 71 RBI this year.
• Bellinger has recorded a hit in two straight games. During his last five outings he is hitting .400 with three home runs, a walk and seven RBIs.
• Jose Caballero is batting .234 with a .291 OBP and 50 RBI for New York this season.
• Caballero brings a two-game hitting streak into this game. During his last five outings he is batting .188 with a home run, three walks and three RBIs.

Twins Player Leaders

• Brooks Lee has 23 doubles, three triples, 23 home runs and 35 walks while batting .245. He's slugging .426 with an on-base percentage of .295.
• Including all qualified hitters, he ranks 87th in batting average, while his on-base percentage ranks 125th and he is 69th in slugging.
• Josh Bell is hitting .253 with 28 doubles, a triple, 20 home runs and 48 walks. He's slugging .423 with an on-base percentage of .317.
• Including all qualified hitters, he ranks 71st in batting average, 91st in on-base percentage and 74th in slugging percentage.
• Kody Clemens has accumulated 118 hits, a team-high for the Twins.
• Luke Keaschall has a .370 on-base percentage while slugging .387. Both lead his team.

Yankees vs Twins Head to Head

• 9/15/2026: 8-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 9/14/2026: 8-3 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/5/2026: 6-1 MIN (Favorite: Yankees, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 7/4/2026: 11-4 MIN (Favorite: Yankees, Spread: -1.5, Total: 10, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 7/3/2026: 5-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 9.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 9/17/2025: 10-5 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 9/16/2025: 10-9 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 9/15/2025: 7-0 MIN (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -205, Underdog Moneyline: +172)
• 8/12/2025: 9-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 8/11/2025: 6-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)

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